海洋化学生态学指导下的药物先导化合物发现与优化

U1706210
2017
D0604.生物海洋学与海洋生物资源
邵长伦
联合基金项目
教授
中国海洋大学
280万元
抗疟;海洋化学生态学;海洋药物先导化合物;发现与优化;构效关系
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Structure-activity relationships and potent cytotoxic activities of terphenyllin derivatives from a small compound library 期刊论文 Waqas Haider;Wei-Feng Xu;Min Liu;Yan-Wei Wu;Yan-Fei Tang;Mei-Yan Wei;Chang-Yun Wang;Ling Lu;Chang-Lun Shao
2 Chemical and bioactive marine natural products of coral-derived microorganisms (2015‒2017) 期刊论文 Xue-Mei Hou;Yang Hai;Yu-Cheng Gu;Chang-Yun Wang;Chang-Lun Shao
3 Marine natural products as potential anti-tubercular agents 期刊论文 Xue-Mei Hou;Chang-Yun Wang;William H. Gerwick;Chang-Lun Shao
4 Brefeldin A delivery nanomicelles in hepatocellular carcinoma therapy: Characterization, cytotoxic evaluation in vitro, and antitumor efficiency in vivo 期刊论文 Jin-Man Zhang;Yao-Yao Jiang;Qun-Fa Huang;Xu-Xiu Lu;Guan-Hai Wang;Chang-Lun Shao;Ming Liu
5 一种8’-羟基十四元大环内酯化合物及其制备方法与作为海洋防污剂的应用 专利 邵长伦;王长云;郑纪勇;徐伟锋;齐月璇;魏美燕
6 一种生物碱类化合物及其制备方法与作为抗单纯疱疹Ⅰ型病毒剂的应用 专利 邵长伦;王长云;胥汝芳;牟晓凤
7 一种内酰胺类化合物及其制备方法和用途 专利 邵长伦;王长云;牟晓凤;胥汝芳
8 Structure modifcation, antialgal, antiplasmodial, and toxic evaluations of a series of new marine-derived 14-membered resorcylic acid lactone derivatives 期刊论文 Wei-Feng Xu;Na-Na Wu;Yan-Wei Wu;Yue-Xuan Qi;Mei-Yan Wei;Laura M. Pineda;Michelle G. Ng;Carmenza Spadafora;Ji-Yong Zheng;Ling Lu;Chang-Yun Wang;Yu-Cheng Gu;Chang-Lun Shao
9 海洋药源微生物来源天然产物的化学结构与生物功能研究 奖励 邵长伦;王长云;侯雪梅;魏美燕
10 Semisynthesis, Antiplasmodial Activity, and Mechanism of Action Studies of Isocoumarin Derivatives 期刊论文 Lorena Coronado;Xue-Qing Zhang;Doriana Dorta;Nerea Escala;Laura M. Pineda;Michelle G. Ng;Esther del Olmo;Chang-Yun Wang;Yu-Cheng Gu;Chang-Lun Shao;Carmenza Spadafora
11 Cochliomycin G, a 14-membered resorcylic acid lactone from a marine-derived fungus Cochliobolus lunatus 期刊论文 Wei-Feng Xu;Xiao-Jia Xue;Yue-Xuan Qi;Na-Na Wu;Chang-Yun Wang;Chang-Lun Shao
12 Integrating molecular networking and 1H NMR to target the isolation of chrysogeamides from a library of marine-derived Penicillium fungi 期刊论文 Xue-Mei Hou;Yue-Ying Li;Yun-Wei Shi;Yao-Wei Fang;Rong Chao;Yu-Cheng Gu;Chang-Yun Wang;Chang-Lun Shao
13 Discovery, absolute assignments, and total synthesis of asperversiamides A–C and their potent activity against Mycobacterium marinum 期刊论文 Xue-Mei Hou;Ting-Mei Liang;Zhi-Yong Guo;Chang-Yun Wang;Chang-Lun Shao
14 Semi-synthesis, cytotoxic evaluation, and structure-activity relationships of brefeldin A derivatives with antileukemia activity 期刊论文 Xu-Xiu Lu;Yao-Yao Jiang;Yan-Wei Wu;Guang-Ying Chen;Chang-Lun Shao;Yu-Cheng Gu;Ming Liu;Mei-Yan Wei
15 一种哌尼诺安衍生物及其制备方法和应用 专利 邵长伦;魏美燕;姜瑶瑶
16 一种喹啉酮类化合物的制备方法与作为抗单纯疱疹Ⅰ型病毒剂的应用 专利 邵长伦;王长云;胥汝芳;管菲菲;魏美燕
17 一种生物碱类化合物及其制备方法与作为抗单纯疱疹Ⅰ型病毒剂的应用 专利 邵长伦;王长云;牟晓凤;胥汝芳
18 一种天然来源大环内酯衍生物及其制备方法和作为抗肿瘤药物的应用 专利 邵长伦;姜瑶瑶;武艳伟;高阳;魏美燕
19 布雷菲德菌素A衍生物及其制备方法和用途 专利 邵长伦;王长云;姜瑶瑶
20 一种大环内酯布雷菲德菌素A酯类衍生物及应用 专利 邵长伦;姜瑶瑶;刘明;王长云;魏美燕;王翠芳
21 一种大环内酯布雷菲德菌素A酯类衍生物及应用 专利 邵长伦;姜瑶瑶;刘明;王长云;魏美燕
22 具有抗病毒、抗疟等药理活性海洋天然产物的发现与应用研究 奖励 邵长伦;王长云;魏美燕
23 Targeted isolation of asperheptatides from a coral-derived fungus using LC-MS/MS-based molecular networking and antitubercular activities of modified cinnamate derivatives 期刊论文 Rong Chao;Xue-Mei Hou;Wei-Feng Xu;Yang Hai;Mei-Yan Wei;Chang-Yun Wang;Yu-Cheng Gu;Chang-Lun Shao
24 17-Hydroxybrevianamide N and its N1-methyl derivative, quinazolinones from a soft-coral-derived Aspergillus sp. fungus: 13S enantiomers as the true natural products 期刊论文 Wei-Feng Xu;Rong Chao;Yang Hai;Yang-Yang Guo;Mei-Yan Wei;Chang-Yun Wang;Chang-Lun Shao
25 Structures and absolute configurations of diketopiperazine alkaloids chrysopiperazines A–C from the gorgonian‐derived Penicillium chrysogenum fungus 期刊论文 Wei-Feng Xu;Ning Mao;Xiao-Jia Xue;Yue-Xuan Qi;Mei-Yan Wei;Chang-Yun Wang;Chang-Lun Shao
26 Semisynthesis and biological evaluation of (+)-sclerotiorin derivatives as antitumor agents for the treatment of hepatocellular carcinoma 期刊论文 Yang Hai;Jia-Jia Geng;Peng-Jie Li;Wei-Ping Ma;Cui-Fang Wang;Mei-Yan Wei;Xue-Mei Hou;Guang-Ying Chen;Yu-Cheng Gu;Ming Liu;Chang-Lun Shao
27 苯并十四元大环内酯类化合物在药物中的应用 专利 邵长伦;王长云;张雪晴;孙继红;魏美燕
28 布雷菲德菌素A衍生物及其制备方法和用途 专利 邵长伦;王长云;姜瑶瑶
29 一种哌尼诺安化合物的用途 专利 邵长伦;王长云;牟晓凤;林永成;李德宝;徐伟锋;姜瑶瑶
30 Recent progresses in marine microbial-derived antiviral natural products 期刊论文 Yun-Fei Teng;Li Xu;Mei-Yan Wei;Chang-Yun Wang;Yu-Cheng Gu;Chang-Lun Shao
31 Design, semisynthesis, insecticidal and antibacterial activities of a series of marine-derived geodin derivatives and their preliminary structure–activity relationships 期刊论文 Rong Chao;Gulab Said;Qun Zhang;Yue-Xuan Qi;Jie Hu;Cai-Juan Zheng;Ji-Yong Zheng;Chang-Lun Shao;Guang-Ying Chen;Mei-Yan Wei
32 一种内酰胺类化合物及其制备方法和用途 专利 邵长伦;王长云;牟晓凤;胥汝芳
33 一种制备哌尼诺安化合物的方法 专利 邵长伦;李德宝;焦亚函
34 一种喹啉酮类化合物的制备方法与作为抗单纯疱疹Ⅰ型病毒剂的应用 专利 邵长伦;王长云;胥汝芳;管菲菲;魏美燕
35 布雷菲德菌素 A 酯类衍生物在抗肿瘤药物中的应用 专利 邵长伦;王长云;魏美燕;姜瑶瑶;刘明;王翠芳
36 Discovery of penipanoid C-inspired 2-(3,4,5-trimethoxybenzoyl) quinazolin-4(3H)-one derivatives as potential anticancer agents by inhibiting cell proliferation and inducing apoptosis in hepatocellular carcinoma cells 期刊论文 Chao-Jie Wang;Xinxin Guo;Rui-Qin Zhai;Changning Sun;Guokai Xiao;Jin Chen;Mei-Yan Wei;Chang-Lun Shao;Yuchao Gu
37 Trends of antimalarial marine natural products: progresses, challenges and opportunities 期刊论文 Yang Hai;Zi-Mu Cai;Peng-Jie Li;Mei-Yan Wei;Chang-Yun Wang;Yu-Cheng Gu;Chang-Lun Shao
38 The intriguing chemistry and biology of sulfur-containing natural products from marine microorganisms (1987–2020) 期刊论文 Yang Hai;Mei-Yan Wei;Chang-Yun Wang;Yu-Cheng Gu;Chang-Lun Shao
39 一种异香豆素类衍生物及其在抗疟药物中的应用 专利 邵长伦;王长云;张雪晴
40 一株海洋来源产布雷菲德菌素A青霉真菌N29及其应用 专利 邵长伦;姜瑶瑶;王翠芳;武艳伟;魏美燕
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