基于隐性基因簇激活策略定向发现深海放线菌中新型抗多重耐药菌先导化合物

U1706206
2017
D0604.生物海洋学与海洋生物资源
李文利
联合基金项目
教授
中国海洋大学
286万元
次级代谢产物;定向发现;深海放线菌;隐性基因簇;异源表达
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 《微生物学通报》之“海洋微生物学主题刊” 专著 张长生;李文利
2 色氨酸分解代谢途径阻断对深海链霉菌ZH66次级代谢及生长的影响 期刊论文 徐明远;肖菲;李花月;鞠建华;李文利
3 海洋环肽化合物及其在制备抗结核分枝杆菌药物中的应用 专利 鞠建华;张天宇;孙长利;刘志永;马俊英
4 Julichrome Monomers from Marine Gastropod Mollusk-Associated Streptomyces and Stereochemical Revision of Julichromes Q(3.5) and Q(3.3) 期刊论文 Dong Yuliang;Ding Wenjuan;Sun Changli;Ji Xiaoqi;Ling Chunyao;Zhou Zhenbin;Chen Zhiyun;Chen Xuehong;Ju Jianhua
5 On-PKS Baeyer-Villiger-type O-atom insertion catalyzed by luciferase-like monooxygenase OvmO during olimycin biosynthesis 期刊论文 Zhang Chunyan;Zhang Huaran;Ju Jianhua
6 A luciferase-like monooxygenase and flavin reductase pair AbmE2/AbmZ catalyzes Baeyer-Villiger oxidation in neoabyssomicin biosynthesis 期刊论文 Ji Xiaoqi;Tu Jiajia;Song Yongxiang;Zhang Chunyan;Wang Liyan;Li Qinglian;Ju Jianhua
7 Targeted isolation of new polycyclic tetramate macrolactams from the deepsea-derived Streptomyces somaliensis SCSIO ZH66 期刊论文 Lukuan Hou;Zengzhi Liu;Dongqi Yu;Huayue Li;Wenli Li
8 Characterization of Tailoring Methyltransferases Involved in K-41A Biosynthesis: Modulating Methylation to Improve K-41A Anti-infective Activity 期刊论文 Chen Jiang;Gui Chun;Wei Qiuyu;Liu Jie;Ye Li;Tian Xinpeng;Gu Yu-Cheng;Li Qinglian;Ju Jianhua
9 第十二届青岛市青年科技奖 奖励 李文利
10 Upregulation of a marine fungal biosynthetic gene cluster by an endobacterial symbiont 期刊论文 Mingwei Shao;Changli Sun;Xiaoxiao Liu;Xiaoxue Wang;Wenli Li;Xiaoyi Wei;Qinglian Li;Jianhua Ju
11 Effective generation of glucosylpiericidins with selective cytotoxicities and insights into their biosynthesis. 期刊论文 Zengzhi Liu;Fei Xiao;Siqi Cai;Chunni Liu;Huayue Li;Ting Wu;Yuechen Jiang;Xin Wang;Qian Che;Tianjiao Zhu;Dehai Li;Wenli Li
12 Macrolactins: biological activity and biosynthesis. 期刊论文 Ting Wu;Fei Xiao;Wenli Li
13 粉蝶霉素糖基转移酶sGT1及应用 专利 李文利;刘增智;李花月;肖菲
14 一种具有酰基转移功能的酶及其应用 专利 李文利;肖菲;刘扬;李花月
15 Borrelidins F–I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89 期刊论文 Jianbin Sun;Junli Shao;Changli Sun;Yongxiang Song;Qinglian Li;Laichun Lu;Yunfeng Hu;Chun Gui;Hua Zhang;Jianhua Ju
16 An unusual type II polyketide synthase system involved in cinnamoyl lipid biosynthesis 期刊论文 Zirong Deng;Jing Liu;Tong Li;Huayue Li;Zengzhi Liu;Yujing Dong;Wenli Li
17 Discovery and biosynthesis of atrovimycin, an antitubercular and antifungal cyclodepsipeptide featuring vicinal-dihydroxylated cinnamic acyl chain 期刊论文 Qing Liu;Zhiyong Liu;Changli Sun;Mingwei Shao;Junying Ma;Xiaoyi Wei;Tianyu Zhang;Wenjun Li;Jianhua Ju
18 环肽类抗生素及其制备方法和在制备抗结核分枝杆菌药物中的应用 专利 马俊英;孙长利;刘志永;张天宇;鞠建华
19 粉蝶霉素糖基转移酶sbmGT1及应用 专利 李文利;刘增智;李花月;肖菲
20 Expanding the structural diversity of drimentines by exploring the promiscuity of two N-methyltransferases 期刊论文 Tingting Yao;Jing Liu;Enjing Jin;Zengzhi Liu;Huayue Li;Qian Che;Tianjiao Zhu;Dehai Li;Wenli Li
21 Bacillaenes: Decomposition trigger point and biofilm enhancement in Bacillus 期刊论文 Huayue Li;Xiao Han;Yujing Dong;Shanshan Xu;Chao Chen;Yingang Feng;Qiu Cui;Wenli Li
22 Genome Mining of Streptomyces atratus SCSIO ZH16: Discovery of Atratumycin and Identification of Its Biosynthetic Gene Cluster 期刊论文 Sun Changli;Yang Zhijie;Zhang Chunyan;Liu Zhiyong;He Jianqiao;Liu Qing;Zhang Tianyu;Ju Jianhua;Ma Junying
23 Biosynthetic Baeyer–Villiger Chemistry Enables Access to Two Anthracene Scaffolds from a Single Gene Cluster in Deep-Sea-Derived Streptomyces olivaceus SCSIO T05 期刊论文 Chunyan Zhang;Changli Sun;Hongbo Huang;Chun Gui;Liyan Wang;Qinglian Li;Jianhua Ju
24 Deciphering a cyclodipeptide synthase pathway encoding prenylated indole alkaloids in Streptomyces leeuwenhoekii 期刊论文 Yuqiao Zhang;Tingting Yao;Yuechen Jiang;Huayue Li;Weichen Yuan;Wenli Li
25 Antibiotic dixiamycins from a cold-seep-derived Streptomyces olivaceus. 期刊论文 Enjing Jin;Huayue Li;Zengzhi Liu;Fei Xiao;Wenli Li
26 Genome-Guided Discovery of Antifungal Filipins from a Deep-Sea-Derived Streptomyces antibioticus 期刊论文 Yilei Bao;Huayue Li;Yujing Dong;He Duan;Hongcheng Li;Wenli Li
27 一种新型异戊烯转移酶及其应用 专利 李文利;姚婷婷;刘晶;李花月;李通
28 SAM依赖型甲基转移酶DmtMT1及应用 专利 李文利;姚婷婷;刘晶;金恩静
29 SAM依赖型甲基转移酶DmtMT2-1的应用 专利 李文利;姚婷婷;刘晶;金恩静
30 Antitubercular Ilamycins from Marine-Derived Streptomyces atratus SCSIO ZH16 Delta ilaR 期刊论文 Sun Changli;Liu Zhiyong;Zhu Xiangcheng;Fan Zhiying;Huang Xuanmei;Wu Qiaoling;Zheng Xiaohong;Qin Xiangjing;Zhang Tianyu;Zhang Hua;Ju Jianhua;Ma Junying
31 AbmV Catalyzes Tandem Ether Installation and Hydroxylation during Neoabyssomicin/Abyssomicin Biosynthesis 期刊论文 Qinglian Li;Wenjuan Ding;Ziwei Yao;Jiajia Tu;Liyan Wang;Hongbo Huang;Shengying Li;Jianhua Ju
32 Next-generation drug discovery to combat antimicrobial resistance 期刊论文 Guoqing Niu;Wenli Li
33 一种酰基转移酶及其用途 专利 李文利;肖菲;刘扬
34 Production of Antitubercular Depsipeptides via Biosynthetic Engineering of Cinnamoyl Units 期刊论文 Yang Zhijie;Sun Changli;Liu Zhiyong;Liu Qing;Zhang Tianyu;Ju Jianhua;Ma Junying
35 Structural basis of specificity for carboxyl-terminated acyl donors in a bacterial acyltransferase 期刊论文 Fei Xiao;Sheng Dong;Yang Liu;Yingang Feng;Huayue Li;Caihong Yun;Qiu Cui;Wenli Li
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