海洋来源新骨架蒽醌内酯AS1041靶向降解肿瘤融合蛋白BCR-ABL的分子机制研究

81872792
2018
H3405.海洋药物
刘明
面上项目
教授
中国海洋大学
57万元
新结构骨架;抗肿瘤;生物活性;海洋微生物资源;融合致癌蛋白BCR-ABL
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Brefeldin A delivery nanomicelles in hepatocellular carcinoma therapy: Characterization, cytotoxic evaluation in vitro, and antitumor efficiency in vivo 期刊论文 Zhang Jin-Man;Jiang Yao-Yao;Huang Qun-Fa;Lu Xu-Xiu;Wang Guan-Hai;Shao Chang-Lun;Liu Ming
2 Semi-Synthesis, Cytotoxic Evaluation, and Structure—Activity Relationships of Brefeldin A Derivatives with Antileukemia Activity 期刊论文 Xuxiu Lu;Yaoyao Jiang;Yanwei Wu;Guangying Chen;Changlun Shao;Yucheng Gu;Ming Liu;Meiyan Wei
3 一种新型溴酚类化合物 DBBD 的抗肿瘤作用 专利 刘明;董辉;刘延凯;王力
4 Xanthohumol, a Prenylated Flavonoid from Hops, Induces Caspase-Dependent Degradation of Oncoprotein BCR-ABL in K562 Cells 期刊论文 Lu Xuxiu;Geng Jiajia;Zhang Jinman;Miao Jinlai;Liu Ming
5 Penicisulfuranol A, a novel C-terminal inhibitor disrupting molecular chaperone function of Hsp90 independent of ATP binding domain 期刊论文 Dai Jiajia;Chen Ao;Zhu Meilin;Qi Xin;Tang Wei;Liu Ming;Li Dehai;Gu Qianqun;Li Jing
6 Semisynthesis and biological evaluation of (þ)-sclerotiorin derivatives as antitumor agents for the treatment of hepatocellular carcinoma 期刊论文 Yang Hai;Jiajia Geng;Pengjie Li;Weiping Ma;Cuifang Wang;Meiyan Wei;Xuemei Hou;Guangying Chen;Yucheng Gu;Ming Liu;ChangLun Shao
7 Dietary prenylated flavonoid xanthohumol alleviates oxidative damage and accelerates diabetic wound healing via Nrf2 activation 期刊论文 Xuxiu Lu;Mingfei Liu;Hui Dong;Jinlai Miao;Dimitrios Stagos;Ming Liu
8 A novel alginate from Sargassum seaweed promotes diabetic wound healing by regulating oxidative stress and angiogenesis 期刊论文 Xuxiu Lu;Ling Qin;Meng Guo;Jiajia Geng;Songtao Dong;Wang Kai;Hui Xu;Changfeng Qu;Jinlai Miao;Ming Liu
9 一种溴酚化合物在抗肿瘤新生血 管生成中的应用 专利 刘明;董松涛;卢玲;刘延凯;王力
10 Brefeldin A Induces Apoptosis, Inhibits BCR-ABL Activation, and Triggers BCR-ABL Degradation in Chronic Myeloid Leukemia K562 Cells. 期刊论文 Zhang Jin-Man;Wang Cui-Fang;Wei Mei-Yan;Dong Hui;Gu Yu-Cheng;Mo Xiao-Mei;Shao Chang-Lun;Liu Ming
11 Progress of Bromophenols in Marine Algae from 2011 to 2020: Structure, Bioactivities, and Applications 期刊论文 Dong Hui;Dong Songtao;Hansen Poul Erik;Stagos Dimitrios;Lin Xiukun;Liu Ming
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