基于CID In-Quadrupole 的阿霉素及多尺度PEG化阿霉素比较药代动力学研究

81603182
2016
H3510.药物代谢与药物动力学
尹磊
青年科学基金项目
主管药师
吉林大学
17万元
PEG化阿霉素;抗肿瘤药物;阿霉素;药物代谢动力学;碰撞诱导解离
2017-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 The Effect of Molecular Structure on Cytotoxicity and Antitumor Activity of PEGylated Nanomedicines. 期刊论文 Wenhai Lin;Lei Yin;Tingting Sun;Tingting Wang;Zhigang xie;Jingkai Gu;Xiabin Jing
2 Development and application of a high-throughput liquid chromatography-tandem mass spectrometric method for the simultaneous determination of thymosin α1 and its recombinant human form in plasma and urine. 期刊论文 Tingting Wang;Lei Yin;Hao Wang;Fawcett JP;Jingkai Gu
3 Differential mobility spectrometry followed by tandem mass spectrometry with multiple ion monitoring for bioanalysis of eptifibatide in rat plasma 期刊论文 Tianming Ren;Runzhi Li;Xiangjun Meng;Fawcett JP;Dong Sun;Jingkai Gu
4 Liquid chromatography tandem mass spectrometry with triple stage fragmentation for highly selective analysis and pharmacokinetics of alarelin in rat plasma. 期刊论文 Zhi Zhang;Runzhi Li;Shihao Liu;Lei Yin;Tongtong Xu;John Paul Fawcett;Jingkai Gu
5 一种生物样本中PEG含量的测定方法 专利 顾景凯;周晓彤;程龙妹;尹磊;杨艳
6 Recent advances in single-cell analysis by mass spectrometry. 期刊论文 Lei Yin;Zhi Zhang;Zeying Liu;Yin Gao;Jingkai Gu
7 MSAll strategy for comprehensive quantitative analysis of PEGylated-doxorubicin, PEG and doxorubicin by LC-high resolution q-q-TOF mass spectrometry coupled with all window acquisition of all fragment ion spectra 期刊论文 Lei Yin;Chong Su;Tianming Ren;xiangjun Meng;Meiyun Shi;J. Paul Fawcett;Mengliang Zhang;Wei Hu;Jingkai Gu
8 Bioanalysis of free and liposomal Amphotericin B in rat plasma using solid phase extraction and protein precipitation followed by LC-MS/MS. 期刊论文 Chong Su;Hong Yang;Hui Sun;Fawcett JP;Dong Sun;Jingkai Gu
9 Therapeutic drug monitoring of vancomycin and voriconazole by liquid chromatography-tandem mass spectrometric method 期刊论文 Yanyan Li;Lei Yin;Yanhua Li;Zhihui Sun;Xiaojun Zhao;Mingyue Gao;Hongliang Wang
10 Comparative pharmacokinetic study of PEGylated gemcitabine and gemcitabine in rats by LC-MS/MS coupled with pre-column derivatization and MSALL technique. 期刊论文 Lei Yin;Tianming Ren;Shiying Zhao;Meiyun Shi;Jingkai Gu
11 Ultrahigh-throughput absolute quantitative analysis of linezolid in human plasma by direct analysis in real time mass spectrometry without chromatographic separation and its application to a pharmacokinetic study. 期刊论文 Lei Yin;Yixuan Feng;Jin Tong;Zhiqiong Guo;Yuyao Zhang;Qi Zhang;Yantong Sun;J. Paul Fawcett;Jingkai Gu
12 Analytical methods for investigating in vivo fate of nanoliposomes: A review. 期刊论文 Chong Su;Yinhze Liu;Yang He;Jingkai Gu
13 A Parallel-Column LC-MS/MS Method for High-Throughput Analysis of Eight Antiepileptic Drugs in Clinical Therapeutic Drug Monitoring 期刊论文 Yin Lei;Shi Meiyun;Wang Tingting;Zhang Miaomin;Zhao Xiaojun;Zhang Ying;Gu Jingkai
14 Development of an UPLC-MS/MS method coupled with in-source CID for quantitative analysis of PEG-PLA copolymer and its application to a pharmacokinetic study in rats 期刊论文 Meiyun Shi;Hui Jiang;Lei Yin;Yajun Liu;Mengyao Xu
15 一种生物样本中PEG化药物的定量测定方法 专利 顾景凯;尹磊;史美云;孟祥骏;宿崇;彭雯雯;陆欢;林文孩;杨艳;景遐斌
16 A LC-MS-MS assay for simultaneous determination of two glycopeptides and two small molecule compounds in human plasma. 期刊论文 Meiyun Shi;Xiaojun Zhao;Tingting Wang;Lei Yin;Yanyan Li
17 Absorption, distribution, metabolism and excretion of the biomaterials used in Nanocarrier drug delivery systems 期刊论文 Chong Su;Yingze Liu;Runzhi Li;Wei Wu;Fawcett JP;Jingkai Gu
18 A validated UPLC-MS/MS method coupled with protein precipitation and ion exchange solid phase extraction for the quantitation of porcine relaxin B29 in dog plasma and its application to a pharmacokinetic study 期刊论文 Chong Su;Hui Sun;Hong Yang;Lei Yin;Jiwen Zhang;John Paul Fawcett;Jingkai Gu
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