桥接细胞与整体的纳米药代动力学研究

81430087
2014
H35.药理学
顾景凯
重点项目
教授
吉林大学
320万元
同步辐射光源显微成像;生物分布;单细胞药代动力学;纳米制剂;纳米药代动力学
2015-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Three candesartan salts with enhanced oral bioavailability 期刊论文 Yingnan Chi;Wenting Xu;Yan Yang;Zhichao Yang;Hongjin Lv;Song Yang;Zhengguo Lin;Jikun Li;Jingkai Gu;Craig L. Hill;Changwen Hu
2 Modified Release and Improved Stability of Unstable BCS II Drug by Using Cyclodextrin Complex as Carrier To Remotely Load Drug into Niosomes 期刊论文 Chi Liandi;Wu Delin;Li Zhuo;Zhang Minmin;Liu Hongchun;Wang Caifen;Gui Shuangying;Geng Meiyu;Li Haiyan;Zhang Jiwen
3 In silico analysis and experimental validation of active compounds from cichorium intybus L. ameliorating liver injury 期刊论文 Guoyu Li;Yaxin Zheng;Fuzhou Sun;Jian Huang;Mengmeng Lou;Jingkai Gu;Jinhui Wang
4 Analytical methods for investigating in vivo fate of nanoliposomes: A review 期刊论文 Chong Su;Yingze Liu;Yang He;Jingkai Gu
5 Differential mobility spectrometry tandem mass spectrometry with multiple ion monitoring for the bioanalysis of liraglutide 期刊论文 Xiangjun Meng;Haitong Xu;Zhi Zhang;John Paul Fawcett;Junru Li;Yan Yang;Jingkai Gu
6 Sodium Salts and Solvate of Rebamipide: Synthesis, Structure, and Pharmacokinetic Study 期刊论文 Chi Yingnan;Liu Chuanrong;Ren Tianming;Wang Xiaoying;Yang Qiuhong;Yang Zhichao;Yang Yan;Yang Song;Gu Jingkai;Hu Changwen
7 Enhanced Platelet Response to Clopidogrel in Zucker Diabetic Fatty Rats due to Impaired Clopidogrel Inactivation by Carboxylesterase 1 and Increased Exposure to Active Metabolite 期刊论文 Yao Hongwei;Bai Ruifeng;Ren Tianming;Wang Yani;Gu Jingkai;Guo Yingjie
8 Non-destructive identification of unknown minor phases in polycrystalline bulk alloys using three-dimensional X-ray diffraction 期刊论文 Yang Yiming;Xu Liang;Wang Yudan;Du Guohao;Yang Sam;Xiao Tiqiao
9 Development and validation of an enantioselective SFC-MS/MS method for simultaneous separation and quantification of oxcarbazepine and its chiral metabolites in beagle dog plasma 期刊论文 Yang Zhichao;Xu Xueyu;Sun Lingxia;Zhao Xue;Wang Hao;Fawcett John Paul;Yang Yan;Gu Jingkai
10 Bioanalysis of free and liposomal Amphotericin B in rat plasma using solid phase extraction and protein precipitation followed by LC-MS/MS 期刊论文 Su Chong;Yang Hong;Sun Hui;Fawcett John Paul;Sun Dong;Gu Jingkai
11 Classification of microcrystalline celluloses via structures of individual particles measured by synchrotron radiation X-ray micro-computed tomography 期刊论文 Fang Longwei;Yin Xianzhen;Wu Li;He Yaping;He Yuanzhi;Qin Wei;Meng Fanyue;York Peter;Xu Xu;Zhang Jiwen
12 Simultaneous determination of carboprost methylate and its active metabolite carboprost in dog plasma by liquid chromatography-tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application to a pharmacokinetic study 期刊论文 Lei Yin;Xiangjun Meng;Xiaotong Zhou;Tinglan Zhang;Heping Sun;Zhichao Yang;Bo Yang;Ning Xiao;J. Paul Fawcett;Yan Yang;Jingkai Gu
13 Anisotropic shrinkage of insect air sacs revealed in vivo by X-ray microtomography 期刊论文 Liang Xu;Rongchang Chen;Guohao Du;Yiming Yang;Feixiang Wang;Biao Deng;Honglan Xie;Tiqiao Xiao
14 Microscopic identification of Chinese medicinal materials based on X-ray phase contrast imaging: from qualitative to quantitative 期刊论文 Xue Y;Liang Z;Tan H;Ni L;Zhao Z;Xiao T;Xu H
15 Differential mobility spectrometry followed by tandem mass spectrometry with multiple ion monitoring for bioanalysis of eptifibatide in rat plasma 期刊论文 Ren Tianming;Li Runzhi;Meng Xiangjun;Fawcett J Paul;Sun Dong;Gu Jingkai
16 Recent advances in single-cell analysis by mass spectrometry. 期刊论文 Yin Lei;Zhang Zhi;Liu Yingze;Gao Yin;Gu Jingkai
17 显微CT 血管系统三维结构的骨架细化算法并行化设计实现 期刊论文 谭海;王大东;薛艳玲;王玉丹;杨一鸣;肖体乔
18 Trantinterol, a novel β2-adrenoceptor agonist, noncompetitively inhibits P-glycoprotein function in vitro and in vivo 期刊论文 Tingting Wang;Yantong Sun;Wenxiao Ma;Zhichao Yang;Junfeng Yang;Jingrui Liu;Hongbo Fan;Yan Yang;Jingkai Gu;J. Paul Fawcett;Yingjie Guo
19 Simultaneous quantitative analysis of polyethylene glycol (PEG), PEGylated paclitaxel and paclitaxel in rats by MS/MSALL technique with hybrid quadrupole time-of-flight mass spectrometry 期刊论文 Heping Sun;Qi Zhang;Zhi Zhang;Jin Tong;Dafeng Chu;Jingkai Gu
20 Development of a GC-MS method for the determination and pharmacokinetics of trans-pi-oxocamphor after intravenous administration of Vitacamphorae injection in rat 期刊论文 Liang Chunsu;Yang Zhichao;Meng Xiangjun;Yin Lei;Fawcett J. Paul;Wang Can;Yang Yan;Wang Jian;Gu Jingkai
21 Identification of ginseng root using quantitative X-ray microtomography 期刊论文 Ye Linlin;Xue Yanling;Wang Yudan;Qi Juncheng;Xiao Tiqiao
22 Poly (L-glutamic acid)-g-methoxy poly (ethylene glycol)-gemcitabine conjugate improves the anticancer efficacy of gemcitabine 期刊论文 Yang Chenguang;Song Wantong;Zhang Dawei;Yu Haiyang;Yin Lei;Shen Na;Deng Mingxiao;Tang Zhaohui;Gu Jingkai;Chen Xuesi
23 一种生物样本中PEG含量的测定方法 专利 顾景凯;周晓彤;程龙妹;尹磊;杨艳
24 Simultaneous quantitative analysis of retagliptin and its main active metabolite in human multiple matrices by liquid chromatography tandem mass spectrometry 期刊论文 Meng Xiangjun;Cai Lanlan;Ren Tianming;Sun Dong;Gu Jingkai
25 Fabrication of β-cyclodextrin and sialic acid copolymer by single pot reaction to site specific drug delivery 期刊论文 Parbeen Singh;Xiaohong Ren;Yaping He;Li Wu;Caifen Wang;Haiyan Li;Vikramjeet Singh;Jiwen Zhang
26 Monochromatic-beam-based dynamic X-ray microtomography based on OSEM-TV algorithm 期刊论文 Xu Liang;Chen Rongchang;Yang Yiming;Deng Biao;Du Guohao;Xie Honglan;Xiao Tiqiao
27 Prediction of Rate Constant for Supramolecular Systems with Multiconfigurations 期刊论文 Guo Tao;Li Haiyan;Wu Li;Guo Zhen;Yin Xianzhen;Wang Caifen;Sun Lixin;Shao Qun;Gu Jingkai;York Peter;Zhang Jiwen
28 Synchrotron radiation-based Fourier-transform infrared spectromicroscopy for characterization of the protein/peptide distribution in single microspheres 期刊论文 Wang Manli;Lu Xiaolong;Yin Xianzhen;Tong Yajun;Peng Weiwei;Wu Li;Li Haiyan;Yang Yan;Gu Jingkai;Xiao Tiqiao;Chen Min;Zhang Jiwen
29 A Unique Collision-Induced Dissociation Reaction of Cholamine Derivatives of Certain Prostaglandins 期刊论文 Dong Sun;Chong Su;Yingze Liu;Xiangjun Meng;John Paul Fawcett;Yingjie Guo;Jingkai Gu
30 Improvement in Thermal Stability of Sucralose by γ-Cyclodextrin Metal-Organic Frameworks 期刊论文 Nana Lv;Tao Guo;Botao Liu;Caifen Wang;Vikaramjeet Singh;Xiaonan Xu;Xue Li;Dawei Chen;Ruxandra Gref;Jiwen Zhang
31 同步辐射显微CT 用于中药颗粒定量结构特征与分形维度的研究 期刊论文 鹿晓龙;郑 琴;殷宪振;肖光清;廖祖华;杨 明;张继稳
32 Microstructural investigation using synchrotron radiation X-ray microtomography reveals taste-masking mechanism of acetaminophen microspheres 期刊论文 Guo Zhen;Yin Xianzhen;Liu Congbiao;Wu Li;Zhu Weifeng;Shao Qun;Peter York;Laurence Patterson;Zhang Jiwen
33 Uptake and release profiles of PEGylated liposomal doxorubicin nanoparticles: A comprehensive picture based on separate determination of encapsulated and total drug concentrations in tissues of tumor-bearing mice 期刊论文 Hao Wang;Mi Zheng;Jingyi Gao;Jing Wang;Qi Zhang;J. Paul Fawcett;Yang He;Gu Jingka
34 Simultaneous Quantification of Simvastatin and Simvastatin Acid in Human Plasma with a Highly Sensitive LC-ESI-MS/MS Method: Application to a Pharmacokinetic Study in Healthy Chinese Volunteers with a Fixed Dose of Simvastatin and Extended-Release Niacin Combination Tablet 期刊论文 Li Qiuying;Yang Yan;Shi Guobing;Zhang Jie;Li Guoqing;Sui Yin;Tang Yunbiao;Gu Jingkai
35 Separation and simultaneous quantitation of PGF2 alpha and its epimer 8-iso-PGF2 alpha using modifier-assisted differential mobility spectrometry tandem mass spectrometry 期刊论文 Liang Chunsu;Sun Hui;Meng Xiangjun;Yin Lei;Fawcett J Paul;Yu Huaidong;Liu Ting;Gu Jingkai
36 Drug nanoclusters formed in confined nano-cages of CD-MOF: dramatic enhancement of solubility and bioavailability of azilsartan 期刊论文 He Yuanzhi;Zhang Wei;Guo Tao;Zhang Guoqing;Qin Wei;Zhang Liu;Wang Caifen;Zhu Weifeng;Yang Ming;Hu Xiaoxiao;Singh Vikramjeet;Wu Li;Gref Ruxandra;Zhang Jiwen
37 Quantitative multi-scale analysis of mineral distributions and fractal pore structures for a heterogeneous Junger Basin shale 期刊论文 Wang Y D;Liu K Y;Yang Y S;Ren Y Q;Hu T;Deng B;Xiao T Q
38 A validated UPLC-MS/MS method coupled with protein precipitation and ion exchange solid phase extraction for the quantitation of porcine relaxin B29 in dog plasma and its application to a pharmacokinetic study 期刊论文 Chong Su;Hui Sun;Hong Yang;Lei Yin;Jiwen Zhang;John Paul Fawcett;Jingkai Gu
39 Template-directed synthesis of a cubic cyclodextrin polymer with aligned channels and enhanced drug payload 期刊论文 Singh Vikramjeet;Guo Tao;Wu Li;Xu Jianghui;Liu Botao;Gref Ruxandra;Zhang Jiwen
40 Application of a high-throughput, parallel HPLC system for quantitative chiral analysis of pantoprazole 期刊论文 Hao Wang;Yantong Sun;Yan Yang;Wei Guo;Mi Zheng;Weiping Zhang;J. Paul Fawcett;Jingkai Gu
41 Three dimensional structural insight of laser drilled orifices in osmotic pump tablets 期刊论文 Wu Li;Wang Lebing;Wang Shuxia;Xiao Tiqiao;Chen Min;Shao Qun;Peter York;Vikaramjeet Singh;Yin Xianzhen;Gu Jingkai;Zhang Jiwen
42 Moisture resistant and biofriendly CD-MOF nanoparticles obtained via cholesterol shielding 期刊论文 Vikramjeet Singh;Tao Guo;Haitong Xu;Li Wu;Jingkai Gu;Chuanbin Wu;Ruxandra Gref;Jiwen Zhang
43 Determination of thymopentin in beagle dog blood by liquid chromatography with tandem mass spectrometry and its application to a preclinical pharmacokinetic study 期刊论文 Meiyun Shi;Yan Yang;Xiaotong Zhou;Lanlan Cai;Chunxue Fang;Can Wang;Heping Sun;Yantong Sun;Yin Gao;Jingkai Gu;J. Paul Fawcett
44 基于蛋白质组学的药物代谢酶与转运体定量分析研究进展 期刊论文 杨 波;王 静;丛宇婷;胡良海;顾景凯
45 一种生物样本中PEG化药物的定量测定方法 专利 顾景凯;尹磊;史美云;孟祥骏;宿崇;彭雯雯;陆欢;林文孩;杨艳;景遐斌
46 Improving the efficiency of small-angle x-ray 2 scattering computed tomography using the 3 OSEM algorithm 期刊论文 TAO HU;YUDAN WANG;GUOHAO DU;YUZHU WANG;WENQIANG HUA;BIAO DENG;HONGLAN XIE;FENGGANG BIAN;TIQIAO XIAO
47 Rapid and sensitive liquid chromatography with tandem mass spectrometry method for the simultaneous quantification of yonkenafil and its major metabolites in rat plasma 期刊论文 Sun Heping;Wang Jiang;Sun Yantong;Peng Wenwen;Sun Lingxia;Yang Yan;Gu Jingkai
48 Cyclodextrin-based metal-organic frameworks particles as efficient carriers for lansoprazole: Study of morphology and chemical composition of individual particles 期刊论文 Li Xue;Guo Tao;Lachmanski Laurent;Manoli Francesco;Menendez Miranda Mario;Manet Ilse;Guo Zhen;Wu Li;Zhang Jiwen;Gref Ruxandra
49 Liquid chromatography tandem mass spectrometry with triple stage fragmentation for highly selective analysis and pharmacokinetics of alarelin in rat plasma 期刊论文 Zhi Zhang;Runzhi Li;Shihao Liu;Lei Yin;Tongtong Xu;John Paul Fawcett;Jingkai Gu
50 Solvents effects on crystallinity and dissolution of beta-artemether 期刊论文 Xu Jianghui;Singh Vikramjeet;Yin Xianzhen;Singh Parbeen;Wu Li;Xu Xiaonan;Guo Tao;Sun Lixin;Gui Shuangying;Zhang Jiwen
51 Biofunctionalization of beta-cyclodextrin nanosponges using cholesterol 期刊论文 Singh Parbeen;Ren Xiaohong;Guo Tao;Wu Li;Shakya Shailendra;He Yaping;Wang Caifen;Maharjan Abi;Singh Vikramjeet;Zhang Jiwen
52 Enhanced stability of vitamin A palmitate microencapsulated by gamma-cyclodextrin metal-organic frameworks 期刊论文 Zhang Guoqing;Meng Fanyue;Guo Zhen;Guo Tao;Peng Hui;Xiao Jian;Liu Botao;Singh Vikaramjeet;Gui Shuangying;York Peter;Qian Wei;Wu Li;Zhang Jiwen
53 Host-guest kinetic interactions between HP-beta-cyclodextrin and drugs for prediction of bitter taste masking 期刊论文 Guo Zhen;Wu Fei;Singh Vikramjeet;Guo Tao;Ren Xiaohong;Yin Xianzhen;Shao Qun;York Peter;Patterson Laurence H;Zhang Jiwen
54 Visualization and quantification of deformation behavior of clopidogrel bisulfate polymorphs during tableting 期刊论文 Yin Xian Zhen;Wu Li;Li Ying;Guo Tao;Li Hai Yan;Xiao Ti Qiao;York Peter;Nangia Ashwini;Gui Shuang Ying;Zhang Ji Wen
55 Development and application of a high-throughput liquid chromatography–tandem mass spectrometric method for the simultaneous determination of thymosin α1 and its recombinant human form in plasma and urine 期刊论文 Tingting Wang;Lei Yin;Hao Wang;John Paul Fawcett;Jingkai Gu
56 High-throughput measurement of drug-cyclodextrin kinetic rateconstants by small molecule microarray using surface plasmonresonance imaging 期刊论文 Vikramjeet Singh;Zhuo Li;Xiaotong Zhou;Xiaonan Xu;Jianghui Xu;Amita Nand;Huajie Wen;Haiyan Li;Jingsong Zhu;Jiwen Zhang
57 Development and Application of an MSALL-Based Approach for the Quantitative Analysis of Linear Polyethylene Glycols in Rat Plasma by Liquid Chromatography Triple-Quadrupole/Time-of-Flight Mass Spectrometry 期刊论文 Xiaotong Zhou;Xiangjun Meng;Longmei Cheng;Chong Su;Yantong Sun;Lingxia Sun;Zhaohui Tang;John Paul Fawcett;Yan Yang;Jingkai Gu
58 Synthesis and Pharmacokinetic Study of Three Gemfibrozil Salts: An Exploration of the Structure-Property Relationship 期刊论文 Yang Qiuhong;Ren Tianming;Yang Song;Li Xiaoqin;Chi Yingnan;Yang Yan;Gu Jingkai;Hu Changwen
59 Determination of lansoprazole enantiomers in dog plasma by column-switching liquid chromatography with tandem mass spectrometry and its application to a preclinical pharmacokinetic study 期刊论文 Wang Hao;Sun Yantong;Meng Xiangjun;Yang Bo;Wang Jian;Yang Yan;Gu Jingkai
60 A comparison report of three advanced methods for drug-cyclodextrin interaction measurements 期刊论文 Singh Vikramjeet;He Yaping;Wang Caifen;Xu Jianghui;Xu Xiaonan;Li Haiyan;Singh Parbeen;York Peter;Sun Lixin;Zhang Jiwen
61 Microwave-Assisted Rapid Synthesis of gamma-Cyclodextrin Metal-Organic Frameworks for Size Control and Efficient Drug Loading 期刊论文 Liu Botao;He Yaping;Han Liping;Singh Vikramjeet;Xu Xiaonan;Guo Tao;Meng Fanyue;Xu Xu;York Peter;Liu Zhaoxin;Zhang Jiwen
62 A robust method for high-precision quantification of the complex three-dimensional vasculatures acquired by X-ray microtomography 期刊论文 Hai Tan;Dadong Wang;Rongxin Li;Changming Sun;Ryan Lagerstrom;You He;Yanling Xue;Tiqiao Xiao
63 Micro-solid phase extraction and LC–MS3 for the determination of triptorelin in rat plasma and application to a pharmacokinetic study 期刊论文 Ren Tianming;Zhang Zhi;John Paul Fawcett;Sun Dong;Gu Jingkai
64 Comparative pharmacokinetic study of PEGylated gemcitabine and gemcitabine in rats by LC-MS/MS coupled with pre-column derivatization and MS ALL technique 期刊论文 顾景凯;Lei Yin;Tianming Ren;Shiying Zhao;Meiyun Shi
65 Ultrahigh-throughput absolute quantitative analysis of linezolid in human plasma by direct analysis in real time mass spectrometry without chromatographic separation and its application to a pharmacokinetic study 期刊论文 Yin Lei;Feng Yixuan;Tong Jin;Guo Zhiqiong;Zhang Yuyao;Zhang Qi;Sun Yantong;John Paul Fawcett;Gu Jingkai
66 Three dimensional distribution of surfactant in microspheres revealed by synchrotron radiation X-ray microcomputed tomography 期刊论文 Wu Li;Wang Manli;Singh Vikramjeet;Li Haiyan;Guo Zhen;Gui Shuangying;York Peter;Xiao Tiqiao;Yin Xianzhen;Zhang Jiwen
67 Absorption, distribution, metabolism and excretion of the biomaterials used in Nanocarrier drug delivery systems 期刊论文 Su Chong;Liu Yingze;Li Runzhi;Wu Wei;Fawcett John Paul;Gu Jingkai
68 Speckle-tracking X-ray phase-contrast imaging for samples with obvious edge-enhancement effect 期刊论文 Wang Feixiang;Wang Yudan;Wei Gongxiang;Du Guohao;Xue Yanling;Hu Tao;Li Ke;Deng Biao;Xie Honglan;Xiao Tiqiao
69 Evaluation of drug loading capabilities of gamma-cyclodextrin-metal organic frameworks by high performance liquid chromatography 期刊论文 Xu Xiaonan;Wang Caifen;Li Haiyan;Li Xue;Liu Botao;Singh Vikramjeet;Wang Shuxia;Sun Lixin;Gref Ruxandra;Zhang Jiwen
70 Composite CD-MOF nanocrystals-containing microspheres for sustained drug delivery 期刊论文 Li Haiyan;Lv Nana;Li Xue;Liu Botao;Feng Jing;Ren Xiaohong;Guo Tao;Chen Dawei;Stoddart J Fraser;Gref Ruxandra;Zhang Jiwen
71 Significant Improvement of Metabolic Characteristics and Bioactivities of Clopidogrel and Analogs by Selective Deuteration 期刊论文 Xu Xueyu;Zhao Xue;Yang Zhichao;Wang Hao;Meng Xiangjun;Su Chong;Liu Mingyuan;Fawcett John Paul;Yang Yan;Gu Jingkai
72 In situ 3D topographic and shape analysis by synchrotron radiation X-ray microtomography for crystal form identification in polymorphic mixtures 期刊论文 Yin Xian Zhen;Xiao Ti Qiao;Nangia Ashwini;Yang Shuo;Lu Xiao Long;Li Hai Yan;Shao Qun;He You;York Peter;Zhang Ji Wen
73 Ordered and disordered cyclodextrin nanosponges with diverse physicochemical properties 期刊论文 Singh Vikramjeet;Xu Jianghui;Wu Li;Liu Botao;Guo Tao;Guo Zhen;York Peter;Gref Ruxandra;Zhang Jiwen
74 The Effect of Molecular Structure on Cytotoxicity and Antitumor Activity of PEGylated Nanomedicines 期刊论文 Lin Wenhai;Yin Lei;Sun Tingting;Wang Tingting;Xie Zhigang;Gu Jingkai;Jing Xiabin
75 Cuboidal tethered cyclodextrin frameworks tailored for hemostasis and injured vessel targeting 期刊论文 He Yaping;Xu Jian;Sun Xian;Ren Xiaohong;Maharjan Abi;York Peter;Su Yong;Li Haiyan;Zhang Jiwen
76 Hydration induced material transfer in membranes of osmotic pump tablets measured by synchrotron radiation based FTIR 期刊论文 Wu Li;Yin Xianzhen;Guo Zhen;Tong Yajun;Feng Jing;York Peter;Xiao Tiqiao;Chen Min;Gu Jingkai;Zhang Jiwen
77 Establishment of a Charge Reversal Derivatization Strategy to Improve the Ionization Efficiency of Limaprost and Investigation of the Fragmentation Patterns of Limaprost Derivatives Via Exclusive Neutral Loss and Survival Yield Method 期刊论文 Sun Dong;Meng Xiangjun;Ren Tianming;Fawcett John Paul;Wang Hualu;Gu Jingkai
78 MSAll strategy for comprehensive quantitative analysis of PEGylated-doxorubicin, PEG and doxorubicin by LC-high resolution q-q-TOF mass spectrometry coupled with all window acquisition of all fragment ion spectra 期刊论文 Lei Yin;Chong Su;Tianming Ren;Xiangjun Meng;Meiyun Shi;J. Paul Fawcett;Mengliang Zhang;Wei Hu;Jingkai Gu
79 Comparative pharmacokinetic study of PEGylated gemcitabine and gemcitabine in rats by LC-MS/MS coupled with pre-column derivatization and MS ALL technique 期刊论文 顾景凯;Lei Yin;Tianming Ren;Shiying Zhao;Meiyun Shi
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