作用于肿瘤微环境的非细胞毒化物型高效抗肿瘤高分子的设计

U1501243
2015
H2710.介入医学与工程
申有青
联合基金项目
教授
浙江大学
237万元
大分子药物;肿瘤微环境;纳米药物;生物医用高分子;肿瘤化疗
2016-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 pH-Sensitive Nanocarrier-Mediated Codelivery of Simvastatin and Noggin siRNA for Synergistic Enhancement of Osteogenesis 期刊论文 Huang Jinsheng;Lin Chaowen;Fang Jintao;Li Xiaoxia;Wang Jin;Deng Shaohui;Zhang Sheng;Su Wanhan;Feng Xiaoreng;Chen Bin;Cheng Du;Shuai Xintao
2 Thiourea-Containing Dendrimer And Thiourea-Containing Hyperbranched Polymer as Well as Preparation Methods Therefor and Applications Thereof 专利 申有青;邵世群;唐建斌;刘祥瑞
3 Tumor-penetrating peptide modified and pH-sensitive polyplexes for tumor targeted siRNA delivery 期刊论文 Zhou Guoyong;Xu Yongmin;Chen Meiwan;Cheng Du;Shuai Xintao
4 Enhanced water solubility, antioxidant activity, and oral absorption of hesperetin by D--tocopheryl polyethylene glycol 1000 succinate and phosphatidylcholine 期刊论文 Gu Su fang;Wang Li ying;Tian Ying jie;Zhou Zhu xian;Tang Jian bin;Liu Xiang rui;Jiang Hai ping;Shen You qing
5 Copper as the Target for Anticancer Nanomedicine 期刊论文 Shao Shiqun;Si Jingxing;Shen Youqing
6 Synthesis and evaluation of a paclitaxel-binding polymeric micelle for efficient breast cancer therapy 期刊论文 Xiang Jiajia;Wu Bihan;Zhou Zhuxian;Hu Shiqi;Piao Ying;Zhou Quan;Wang Guowei;Tang Jianbin;Liu Xiangrui;Shen Youqing
7 高分子抗肿瘤纳米药物的挑战与发展 期刊论文 孙瑞;邱娜莎;申有青
8 一种聚乙二醇-聚赖氨酸/异硫氰酸酯键合物及其作为药物载体的应用 专利 申有青;吴碧寒;相佳佳;朴莹
9 抗肿瘤纳米药物的设计与挑战 期刊论文 刘婧;胡豆豆;周泉;申有青
10 Drug-binding albumins forming stabilized nanoparticles for efficient anticancer therapy 期刊论文 Huang Jianxiang;Wu Bihan;Zhou Zhuxian;Hu Shiqi;Xu Hongxia;Piao Ying;Zheng Hao;Tang Jianbin;Liu Xiangrui;Shen Youqing
11 A neutral water-soluble mitochondria-targeting polymer 期刊论文 Geng Yu;Zhong Yin;Zhou Quan;Chen Siqin;Piao Ying;Yin Wei;Lu Hua;Shen Youqing
12 Hypoxia-targeting dendritic MRI contrast agent based on internally hydroxy dendrimer for tumor imaging 期刊论文 Han Yuxin;Zhou Xiaoxuan;Qian Yue;Hu Hongjie;Zhou Zhuxian;Liu Xiangrui;Tang Jianbin;Shen Youqing
13 Enzyme-activatable polymer-drug conjugate augments tumour penetration and treatment efficacy 期刊论文 Zhou Quan;Shao Shiqun;Wang Jinqiang;Xu Changhuo;Xiang Jiajia;Piao Ying;Zhou Zhuxian;Yu Qingsong;Tang Jianbin;Liu Xiangrui;Gan Zhihua;Mo Ran;Gu Zhen;Shen Youqing
14 Reactive Oxygen Species (ROS)-Responsive Charge-Switchable Nanocarriers for Gene Therapy of Metastatic Cancer 期刊论文 Xiang;Jiajia;Liu;Xin;Zhou;Zhuxian;Zhu;Dingcheng;Zhou;Quan;Piao;Ying;Jiang;Liming;Tang;Jianbin;Liu;Xiangrui;Shen;Youqing
15 一种自组装载药系统及其复合制剂的制备方法 专利 申有青;胡诗琪
16 一种γ-谷氨酰转肽酶催化水解致电荷翻转的聚合物及其在药物输送领域的应用 专利 申有青;刘欣;唐建斌;刘祥瑞
17 Paraptosis-Inducing Nanomedicine Overcomes Cancer Drug Resistance for a Potent Cancer Therapy 期刊论文 Zhou Yongcun;Huang Feiteng;Yang Ying;Wang Pingli;Zhang Zhen;Tang Yining;Shen Youqing;Wang Kai
18 Assemblies of Peptide-Cytotoxin Conjugates for Tumor-Homing Chemotherapy 期刊论文 Wang Jinqiang;Hu Shiqi;Mao Weiwei;Xiang Jiajia;Zhou Zhuxian;Liu Xiangrui;Tang Jianbin;Shen Youqing
19 Gold nanocage decorated pH-sensitive micelle for highly effective photothermo-chemotherapy and photoacoustic imaging 期刊论文 Zhou Guoyong;Xiao Hong;Li Xiaoxia;Huang Yi;Song Wei;Song Liang;Chen Meiwan;Cheng Du;Shuai Xintao
20 Stabilized calcium phosphate hybrid nanocomposite using a benzoxaborole-containing polymer for pH-responsive siRNA delivery 期刊论文 Zhou Quan;Wang Yue;Xiang Jiajia;Piao Ying;Zhou Zhuxian;Tang Jianbin;Liu Xiangrui;Shen Youqing
21 Synergistic effects of liposomes encapsulating atorvastatin calcium and curcumin and targeting dysfunctional endothelial cells in reducing atherosclerosis 期刊论文 Li Xiaoxia;Xiao Hong;Lin Chaowen;Sun Weitong;Wu Teng;Wang Jin;Chen Bin;Chen Xia;Cheng Du
22 Synergistic MicroRNA Therapy in Liver Fibrotic Rat Using MRI-Visible Nanocarrier Targeting Hepatic Stellate Cells 期刊论文 Wu Jun;Huang Jinsheng;Kuang Sichi;Chen Jingbiao;Li Xiaoxia;Chen Bin;Wang Jin;Cheng Du;Shuai Xintao
23 缓释复合材料及其制备方法和应用 专利 申有青;崔婧;黄璇
24 N-Oxide Polymer-Cupric Ion Nanogels Potentiate Disulfiram for Cancer Therapy 期刊论文 Zhong Yin;Sun Rui;Geng Yu;Zhou Quan;Piao Ying;Xie Tao;Zhou Ruhong;Shen Youqing
25 用单一单体高效合成聚羟基丙烯亚胺树状高分子 期刊论文 周永存;周珠贤;申有青
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