ADP核糖基化修饰和相分离对DNA损伤响应的转录调控机制与功能
92053114
2020
C0505.蛋白质、多肽与酶生物化学
陆华松
重大研究计划
研究员
浙江大学
60万元
基因转录与相变调控;DNA损伤应答;修饰分子;基于代谢中间物的功能基团修饰;ADP核糖基化修饰
2021-01-01到2023-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Top(ological-operon) secret behind the long-range transcriptional coupling | 期刊论文 | Lei Zhang;Zhibing Wu;Huasong Lu |
| 2 | R-loop dependent promoter-proximal termination ensures genome stability | 期刊论文 | Congling Xu;Chengyu Li;Jiwei Chen;Yan Xiong;Zhibin Qiao;Pengyu Fan;Conghui Li;Shuangyu Ma;Jin Liu;Aixia Song;Bolin Tao;Tao Xu;Wei Xu;Yayun Chi;Jingyan Xue;Pu Wang;Dan Ye;Hongzhou Gu;Peng Zhang;Qiong Wang;Ruijing Xiao;Jingdong Cheng;Hai Zheng;Xiaoli Yu;Zhen Zhang;Jiong Wu;Kaiwei Liang;Yan-Jun Liu;Huasong Lu;Fei Xavier Chen |
| 3 | Targeting liquid–liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity | 期刊论文 | Shuai Wang;Tong Dai;Ziran Qin;Ting Pan;Feng Chu;Lingfeng Lou;Long Zhang;Bing Yang;Huizhe Huang;Huasong Lu;Fangfang Zhou |
| 4 | Phase separation in gene transcription control | 期刊论文 | Li Chengyu;Li Zhuo;Wu Zhibing;Lu Huasong |
| 5 | Reprogramming transcription after DNA damage: recognition, response, repair, and restart | 期刊论文 | Huasong Lu;Min Yang;Qiang Zhou |
| 6 | Poly(ADP-ribosylation) of P-TEFb by PARP1 disrupts phase separation to inhibit global transcription after DNA damage | 期刊论文 | Huanyi Fu;Rongdiao Liu;Zixuan Jia;Ran Li;Feifeng Zhu;Wenxuan Zhu;Yangqing Shao;Yiyang Jin;Yuhua Xue;Jun Huang;Kunxin Luo;Xiang Gao;Huasong Lu;Qiang Zhou |
| 7 | A natural product targets BRD4 to inhibit phase separation and gene transcription | 期刊论文 | Cong Wang;Huasong Lu;Xiangzhong Liu;Xiang Gao;Wenjing Tian;Haifeng Chen;Yuhua Xue;Qiang Zhou |
| 8 | A chaperone-like function of FUS ensures TAZ condensate dynamics and transcriptional activation | 期刊论文 | Yangqing Shao;Xin Shu;Yi Lu;Wenxuan Zhu;Ran Li;Huanyi Fu;Chengyu Li;Wei Sun;Zhuo Li;Yitong Zhang;Xiaolei Cao;Xifu Ye;Emmanuel Ajiboye;Bin Zhao;Long Zhang;Haifan Wu;Xin-Hua Feng;Bing Yang;Huasong Lu |
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