P2X7受体介导的caspase-1/NLRP3炎症小体活化调控酒精性肝病的作用机制研究

81560597
2015
H3504.抗炎与免疫药物药理
廉丽花
地区科学基金项目
教授
延边大学
42万元
炎症小体;酒精性肝纤维化;P2X7受体;酒精性脂肪肝
2016-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Oligomeric proanthocyanidin derived from grape seeds inhibited NFkB signaling in activated HSC: Involvement of JNK/ERK MAPK and PI3K/Akt pathways 期刊论文 Jiang Min;Wu Yan-Ling;Li Xia;Zhang Yu;Xia Kai-Li;Cui Ben-Wen;Lian Li-Hua;Nan Ji-Xing
2 Gentiopicroside Ameliorates LKB1/AMPK-Dependent Alcoholic Hepatosteatosis via P2x7R-NLRP3 inflammasome 会议论文 李夏;张玉;夏凯丽;姜敏;崔本文;吴艳玲;南极星;廉丽花
3 一种半萜内酯类化合物及其制备方法和应用 专利 李熙峰;南极星;冯佳;廉丽花;金英今;尹成日
4 Liver kinase B1/AMP-activated protein kinase-mediated regulation by gentiopicroside ameliorates P2X7 receptor-dependent alcoholic hepatosteatosis. 期刊论文 Xia Li;Yu Zhang;Quan Jin;Kai-Li Xia;Min Jiang;Ben-Wen Cui;Shun-Zong Song;Li-Hua Lian;Ji-Xing Nan
5 吉林省第七批拔尖创新人才第二层次 奖励 廉丽花
6 东北龙胆对小鼠暴发性肝衰竭的保护作用机制 会议论文 廉丽花
7 Thymoquinone Attenuates Acetaminophen Overdose-Induced Acute Liver Injury and Inflammation Via Regulation of JNK and AMPK Signaling Pathway 期刊论文 Cui Ben Wen;Bai Ting;Yang Yong;Zhang Yu;Jiang Min;Yang Hong Xu;Wu Mei;Liu Jian;Qiao Chun Ying;Zhan Zi Ying;Wu Yan Ling;Kang Dong Zhou;Lian Li Hua;Nan Ji Xing
8 Pleurotus citrinopileatus alleviates alcohol-induced fatty liver via upregulating AMPK 会议论文 刘键;吴梅;杨红旭;李夏;崔本文;张玉;姜敏;李英;尚月;金明姬;吴艳玲;南极星;廉丽花
9 Amelioration of Alcoholic Liver Steatosis by Dihydroquercetin through the Modulation of AMPK-Dependent Lipogenesis Mediated by P2X7R-NLRP3-Inflammasome Activation. 期刊论文 Zhang Yu;Jin Quan;Li Xia;Jiang Min;Cui Ben-Wen;Xia Kai-Li;Wu Yan-Ling;Lian Li-Hua;Nan Ji-Xing
10 葡萄籽中的原花青素通过PI3K/Akt信号通路抑制了LPS诱导的HSC-T6细胞系的激活 会议论文 廉丽花
11 长白山药用植物活性成分对慢性炎症的靶向干预机制研究 奖励 廉丽花;吴艳玲;南极星;金泉;张玉
12 东北龙胆对D-氨基半乳糖联合脂多糖所致小鼠暴发性肝功能衰竭的保护作用 期刊论文 夏凯丽;姜敏;崔本文;张玉;郑金花;吴艳玲;南极星;廉丽花
13 Inhibition of P2x7R-NLRP3 inflammasome activation by Pleurotus citrinopileatus: a possible protective role in alcoholic hepatosteatosis. 期刊论文 Li Xia;Jin Quan;Zhang Yu;Wu Yan-Ling;Jin Cheng-Min;Cui Ben-Wen;Li Ying;Jin Ming-Ji;Shang Yue;Jiang Min;Yang Hong-Xu;Wu Mei;Liu Jian;Lian Li-Hua;Nan Ji-Xing
14 第二十二届中国药理学会施维雅青年药理学家奖 奖励 廉丽花
15 二氢槲皮素对高脂饲料联合酒精狂饮小鼠肝脏脂肪蓄积的干预机制 期刊论文 吴梅;乔春莹;叶欢;吴艳玲;南极星;廉丽花
16 Gentiopicroside Alleviates Alcoholic Fatty Liver through Suppression of P2X7r-Caspapse-1 Pathway 会议论文 ZHANG Yu;ZHENG Jin-hua;ZHANG Fen-yu;HAN Xin;LI Zhi-man;WU Yan-ling;NAN Ji-xing;Lian Li-Hua
17 P2X7r antagonist suppressedhepatic stellate cells activation through NLPR3 inflammasome signaling 会议论文 郑金花;张玉;张粉玉;韩欣;李志满;吴艳玲;廉丽花;南极星
18 Gentiopicroside P2x7R-NLRP3 inflammasome-Dependently Improved Alcoholic Hepatosteatosis 会议论文 吴梅;刘键;杨红旭;李夏;崔本文;张玉;姜敏;李英;尚月;金明姬;吴艳玲;南极星;廉丽花
19 Blockade of P2X7R regulates the crosstalk between hepatic stellate cells and macrophages in hepatic fibrogenesis 会议论文 廉丽花
20 Pleurotus citrinopileatus alleviates alcohol-induced fatty liver via upregulating AMPK signaling 会议论文 张玉;崔本文;李夏;姜敏;吴艳玲;南极星;廉丽花
21 二氢槲皮素对高脂饲料联合酒精狂饮所致小鼠肝脏脂肪蓄积的干预机制 会议论文 刘键;尚月;吴艳玲;廉丽花;南极星
22 Potentiation of hepatic stellate cell activation by extracellular ATP is dependent on P2X7R-mediated NLRP3 inflammasome activation. 期刊论文 Jiang Shuang;Zhang Yu;Zheng Jin-Hua;Li Xia;Yao You-Li;Wu Yan-Ling;Song Shun-Zong;Sun Peng;Nan Ji-Xing;Lian Li-Hua
23 Tetrandrine regulates hepatic stellate cell activation via TAK1 and NF-kappa B signaling 期刊论文 Li Xia;Jin Quan;Wu Yan-Ling;Sun Peng;Jiang Shuang;Zhang Yu;Zhang De-Quan;Zhang Yu-Jing;Lian Li-Hua;Nan Ji-Xing
24 P2X7 receptor-targeted regulation by tetrahydroxystilbene glucoside in alcoholic hepatosteatosis: A new strategy towards macrophage–hepatocyte crosstalk 期刊论文 Yu Zhang;Min Jiang;Ben-Wen Cui;Cheng Hua Jin;Yan-Ling Wu;Yue Shang;Hong-Xu Yang;Mei Wu;Jian Liu;Chun-Ying Qiao;Zi-Ying Zhan;Huan Ye;Guang-Hao Zheng;Quan jin;Li-Hua Lian;Ji-Xing Nan
25 Leucodin attenuates inflammatory response in macrophages and lipid accumulation in steatotic hepatocytes via P2x7 receptor pathway: A potential role in alcoholic liver disease. 期刊论文 Shang Yue;Li Xi-Feng;Jin Ming-Ji;Li Ying;Wu Yan-Ling;Jin Quan;Zhang Yu;Li Xia;Jiang Min;Cui Ben-Wen;Lian Li-Hua;Nan Ji-Xing
26 Thymoquinone attenuates acetaminophen overdose-induced liver injury and inflammation via regulation of JNK and AMPK signaling pathway 会议论文 杨红旭;吴梅;刘键;李夏;崔本文;张玉;姜敏;李英;尚月;金明姬;吴艳玲;南极星;廉丽花
27 天然活性成分基于P2X7受体-NLRP3炎症小体调控酒精性肝脂肪蓄积与肝纤维化机制 会议论文 廉丽花
28 Upregulation of SIRT1-AMPK by thymoquinone in hepatic stellate cells ameliorates liver injury 期刊论文 Yang Yong;Bai Ting;Yao You-Li;Zhang De-Quan;Wu Yan-Ling;Lian Li-Hua;Nan Ji-Xing
29 Inhibition of P2X7R modulates ECM deposition in HSCs and the crosstalk with macrophages in liver fibrosis 会议论文 姜敏;崔本文;张玉;吴艳玲;南极星;廉丽花
30 茵陈篙中去乙酰氧母菊素基于P2x7受体调控巨噬细胞的炎症反应和酒精暴露肝细胞的脂质蓄积的机制 会议论文 尚月;刘键;吴艳玲;南极星;廉丽花
31 Salidroside Regulates Inflammatory Response in Raw 264.7 Macrophages via TLR4/TAK1 and Ameliorates Inflammation in Alcohol Binge Drinking-Induced Liver Injury 期刊论文 Sun Peng;Song Shun-Zong;Jiang Shuang;Li Xia;Yao You-Li;Wu Yan-Ling;Lian Li-Hua;Nan Ji-Xing
32 Dihydroquercetin ameliorates alcoholic liver steatosis through P2x7R-NLRP3 inflammasome pathway 会议论文 张玉;李夏;夏凯丽;姜敏;崔本文;吴艳玲;南极星;廉丽花
33 红景天苷基于TLR4/ TAK1调控炎性肝损伤 会议论文 廉丽花
34 东北龙胆基于ERK/JNK通路保护小鼠暴发性肝衰竭 会议论文 廉丽花
35 Design, synthesis, and antifibrosis evaluation of 4-(benzo-[c][1,2,5]thiadiazol-5-yl)-3(5)-(6-methyl- pyridin-2-yl)pyrazole and 3(5)-(6-methylpyridin-2-yl)-4-(thieno-[3,2,-c]pyridin-2-yl)pyrazole derivatives 期刊论文 Zhu Wen Jing;Cui Ben Wen;Wang Hui Min;Nan Ji Xing;Piao Hu Ri;Lian Li Hua;Jin Cheng Hua
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