胆固醇感受器SCAP/SREBP2/Insig-1在NLRP3炎症小体活化及其相关炎症代谢性疾病中的功能和机制研究
81730047
2017
H11.医学免疫学
王迪
重点项目
教授
浙江大学
293万元
炎症小体;代谢综合征;胆固醇“从头合成”;NLRP3;SCAP/SREBP2/Insig-1
2018-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Intestinal-derived HDL: The portal guardian of the liver. | 期刊论文 | Sheng Chen;Di Wang |
| 2 | One-carbon metabolism supports S-adenosylmethionine and histone methylation to drive inflammatory macrophages | 期刊论文 | Weiwei Yu;Zhen Wang;Kailian Zhang;Zhexu Chi;Ting Xu;Danlu Jiang;Sheng Chen;Wenxin Li;Xuyan Yang;Xue Zhang;Yingliang Wu;Di Wang |
| 3 | Gasdermin D maintains bone mass by rewiring the endo-lysosomal pathway of osteoclastic bone resorption | 期刊论文 | Mobai Li;Dehang Yang;Huige Yan;Zhibin Tang;Danlu Jiang;Jian Zhang;Zhexu Chi;Wanyun Nie;Wenxuan Zhen;Weiwei Yu;Sheng Chen;Zhen Wang;Qianzhou Yu;Xue Zhang;Fan Yang;Shunwu Fan;Xianfeng Lin;Di Wang |
| 4 | Ubiquitination of NLRP3 by gp78/Insig-1 restrains NLRP3 inflammasome activation | 期刊论文 | Ting Xu;Weiwei Yu;Hui Fang;Zhen Wang;Zhexu Chi;Xingchen Guo;Danlu Jiang;Kailian Zhang;Sheng Chen;Mobai Li;Yuxian Guo;Jian Zhang;Dehang Yang;Qianzhou Yu;Di Wang;Xue Zhang |
| 5 | Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1. | 期刊论文 | Chen Sheng;Wenyu Cui;Zhexu Chi;Qian Xiao;Tianyi Hu;Qizhen Ye;Kaixiang Zhu;Weiwei Yu;Zhen Wang;Chengxuan Yu;Xiang Pan;Siqi Dai;Qi Yang;Jiacheng Jin;Jian Zhang;Mobai Li;Dehang Yang;Qianzhou Yu;Quanquan Wang;Xiafei Yu;Wei Yang;Xue Zhang;Junbin Qian;Kefeng Ding;Di Wang |
| 6 | Epithelial Gasdermin D shapes the host-microbial interface by driving mucus layer formation | 期刊论文 | Jian Zhang;Qianzhou Yu;Danlu Jiang;Kang Yu;Weiwei Yu;Zhexu Chi;Sheng Chen;Mobai Li;Dehang Yang;Zhen Wang;Ting Xu;Xingchen Guo;Kailian Zhang;Hui Fang;Qizhen Ye;Yong He;Xue Zhang;Di Wang |
| 7 | Cholesterol homeostatic regulator SCAP-SREBP2 integrates NLRP3 inflammasome activation and cholesterol biosynthetic signaling in macrophages. | 期刊论文 | Chuansheng Guo;Zhexu Chi;Danlu Jiang;Ting Xu;Weiwei Yu;Zhen Wang;Sheng Chen;Li Zhang;Qianyun Liu;Xingchen Guo;Wenxin Li;Linrong Lu;Yingliang Wu;Bao-Liang Song;Di Wang |
| 8 | Kir2.1-mediated membrane potential promotes nutrient acquisition and inflammation through regulation of nutrient transporters | 期刊论文 | Weiwei Yu;Zhen Wang;Xiafei Yu;Yonghui Zhao;Zili Xie;Kailian Zhang;Zhexu Chi;Sheng Chen;Ting Xu;Danlu Jiang;Xingchen Guo;Mobai Li;Jian Zhang;Hui Fang;Dehang Yang;Yuxian Guo;Xuyan Yang;Xue Zhang;Yingliang Wu;Wei Yang;Di Wang |
| 9 | Histone deacetylase 3 couples mitochondria to drive IL-1β-dependent inflammation by configuring fatty acid oxidation | 期刊论文 | Zhexu Chi;Sheng Chen;Ting Xu;Wenxuan Zhen;Weiwei Yu;Danlu Jiang;Xingchen Guo;Zhen Wang;Kailian Zhang;Mobai Li;Jian Zhang;Hui Fang;Dehang Yang;Qizhen Ye;Xuyuan Yang;Hui Lin;Fan Yang;Xue Zhang;Di Wang |
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