FBXW7与LSD1非降解结合调节DNA损伤修复和肺癌形成的作用及机理

81630076
2016
H18.肿瘤学
孙毅
重点项目
教授
浙江大学
278万元
肺癌发生;FBXW7;表观遗传调控;DNA;LSD1;损伤修复
2017-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Cullin-RING Ligase 5: Functional characterization and its role in human cancers 期刊论文 Yongchao Zhao;Xiufang Xiong;Yi Sun
2 Protein neddylation and its alterations in human cancers for targeted therapy 期刊论文 Zhou Lisha;Zhang Wenjuan;Sun Yi;Jia Lijun
3 Targeting Protein Neddylation to Inactivate Cullin-RING Ligases by Gossypol: A Lucky Hit or a New Start? 期刊论文 Yu Qing;Sun Yi
4 LSD1 destabilizes FBXW7 and abrogates FBXW7 functions independent of its demethylase activity 期刊论文 Lan Huiyin;Tan Mingjia;Zhang Qiang;Yang Fei;Wang Siyuan;Li Hua;Xiong Xiufang;Sun Yi
5 The Negative Cross-Talk between SAG/RBX2/ROC2 and APC/C E3 Ligases in Regulation of Cell Cycle Progression and Drug Resistance 期刊论文 Shizhen Zhang;Yanwen Shen;Hua Li;Chao Bi;Yilun Sun;Xiufang Xiong;Wenyi Wei;Yi Sun
6 Inactivation of ribosomal protein S27-like impairs DNA interstrand cross-link repair by destabilization of FANCD2 and FANCI 期刊论文 Sun Siyuan;He Hengqian;Ma Yuanyuan;Xu Jie;Chen Guoan;Sun Yi;Xiong Xiufang
7 FBXW2 suppresses migration and invasion of lung cancer cells via promoting beta-catenin ubiquitylation and degradation 期刊论文 Yang Fei;Xu Jie;Li Hua;Tan Mingjia;Xiong Xiufang;Sun Yi
8 Neddylation inhibitor MLN4924 suppresses cilia formation by modulating AKT1 期刊论文 Mao Hongmei;Tang Zaiming;Li Hue;Sun Bo;Tan Mingjia;Fan Shaohua;Zhu Yuan;Sun Yi
9 The FBXW7-SHOC2-Raptor Axis Controls the Cross-Talks between the RAS-ERK and mTORC1 Signaling Pathways 期刊论文 Xie Chuan-Ming;Tan Mingjia;Lin Xiao-Tong;Wu Di;Jiang Yihan;Tan Ye;Li Haomin;Ma Yuanyuan;Xiong Xiufang;Sun Yi
10 SCF beta-TrCP-mediated degradation of TOP2 beta promotes cancer cell survival in response to chemotherapeutic drugs targeting topoisomerase II 期刊论文 Shu Jianfeng;Cui Danrui;Ma Ying;Xiong Xiufang;Sun Yi;Zhao Yongchao
11 USP2 is an SKP2 deubiquitylase that stabilizes both SKP2 and its substrates. 期刊论文 Zhang Fengwu;Zhao Yongchao;Sun Yi
12 Inactivation of ribosomal protein S27-like confers radiosensitivity via the Mdm2-p53 and Mdm2-MRN-ATM axes 期刊论文 Zhao Yongchao;Tan Mingjia;Liu Xia;Xiong Xiufang;Sun Yi
13 Tumor Suppressor FBXW7 and Its Regulation of DNA Damage Response and Repair. 期刊论文 Lan Huiyin;Sun Yi
14 DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals 期刊论文 Chen Xiaoyu;Xiong Xiufang;Cui Danrui;Yang Fei;Wei Dongping;Li Haomin;Shu Jianfeng;Bi Yanli;Dai Xiaoqing;Gong Longyuan;Sun Yi;Zhao Yongchao
15 UBE2M Is a Stress-Inducible Dual E2 for Neddylation and Ubiquitylation that Promotes Targeted Degradation of UBE2F 期刊论文 Zhou Weihua;Xu Jie;Tan Mingjia;Li Haomin;Li Hua;Wei Wenyi;Sun Yi
16 Ribosomal protein S27-like regulates autophagy via the β-TrCP-DEPTOR-mTORC1 axis. 期刊论文 Xiong Xiufang;Liu Xia;Li Haomin;He Hengqian;Sun Yi;Zhao Yongchao
17 Overcoming Resistance to AC0010, a Third Generation of EGFR Inhibitor, by Targeting c-MET and BCL-2 期刊论文 Xu Wanhong;Tang Wei;Li Tingting;Zhang Xiaoying;Sun Yi
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