利用CRISPR/Cas9技术研究先天性眼球震颤相关FRMD7基因突变的致病机制

81400933
2014
H0901.神经系统发育与代谢异常
浦佳丽
青年科学基金项目
主治医师
浙江大学
23万元
先天性特发性眼球震颤;规律成簇的间隔短回文重复序列CRISPR/Cas9核酸酶;信号传导通路;神经元生长发育;FRMD7基因
2015-01-01到2017-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 ZFN、TALEN和CRISPR/Cas9基因编辑技术在疾病研究及治疗中的应用 期刊论文 赵国华;浦佳丽;唐北沙
2 Plasma Exosomes Spread and Cluster Around β-Amyloid Plaques in an Animal Model of Alzheimer's Disease. 期刊论文 Zheng Tingting;Pu Jiali;Chen Yanxing;Mao Yanfang;Guo Zhangyu;Pan Hongyu;Zhang Ling;Zhang Heng;Sun Binggui;Zhang Baorong
3 Exosomes Secreted from HEK293-APP Swe/Ind Cells Impair the Hippocampal Neurogenesis 期刊论文 Zheng Tingting;Pu Jiali;Chen Yanxing;Guo Zhangyu;Pan Hongyu;Zhang Ling;Zhang Heng;Sun Binggui;Zhang Baorong
4 Stable cell lines of human SH-SY5Y uniformly expressing wild-type or mutant-type FERM domain containing 7 gene 期刊论文 Pu Jiali;Mao Yanfang;Xu Lingjia;Zheng Tingting;Zhang Baorong
5 Induced neural stem/precursor cells for fundamental studies and potential application in neurodegenerative diseases 期刊论文 Shen Ting;Pu Jiali;Zheng Tingting;Zhang Baorong
6 An update on potential therapeutic strategies for Parkinson's disease based on pathogenic mechanisms 期刊论文 Shen Ting;Pu Jiali;Si Xiaoli;Ye Rong;Zhang Baorong
7 Progress andChallenges of Cell Replacement Therapy for Neurodegenerative Diseases Based onDirect Neural Reprogramming 期刊论文 Chen Ying;Pu Jiali;Zhang Baorong
8 Intracranial hypertension as the primary symptom of gastric signet-ring cell carcinoma: A case report and literature review 期刊论文 Pu Jiali;Xu Lingjia;Yin Xinzhen;Zhang Baorong
9 Utilization of TALEN and CRISPR/Cas9 technologies for gene targeting and modification 期刊论文 Pu Jiali;Frescas David;Zhang Baorong;Feng Jian
10 Alpha-Synuclein inParkinson's Disease: From Pathogenetic Dysfunction to Potential ClinicalApplication 期刊论文 Xu Lingjia;Pu Jiali
11 Long-term treatment with intranasal insulin ameliorates cognitive impairment, tau hyperphosphorylation, and microglial activation in a streptozotocin-induced Alzheimer's rat model 期刊论文 Guo Zhangyu;Chen Yanxing;Mao Yan-Fang;Zheng Tingting;Jiang Yasi;Yan Yaping;Yin Xinzhen;Zhang Baorong
12 Straight sinus dural arteriovenous fistula presenting with reversible parkinsonism: A case report and literature review. 期刊论文 PU JIALI;SI XIAOLI;YE RONG;ZHANG BAORONG
13 Structure, Distribution, and Genetic Profile of α-Synuclein and Their Potential Clinical Application in Parkinson’s Disease 期刊论文 SI XIAOLI;PU JIALI;ZHANG BAORONG
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