TREM2的功能效应及其突变体参与阿尔茨海默病发生的分子机制研究
81771164
2017
H0902.意识障碍与认知功能障碍
郑红花
面上项目
教授
厦门大学
54万元
髓细胞触发受体-2;包裹屏障作用;阿尔茨海默病;突触可塑性;小胶质细胞
2018-01-01到2021-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Synaptic Adhesion Molecule Pcdh-gamma C5 Mediates Synaptic Dysfunction in Alzheimer's Disease | 期刊论文 | Li Yanfang;Chen Zhicai;Gao Yue;Pan Gaojie;Zheng Honghua;Zhang Yunwu;Xu Huaxi;Bu Guojun;Zheng Hui |
| 2 | Proteolytic Shedding of Human Colony-Stimulating Factor 1 Receptor and its implication | 期刊论文 | Wei Yue;Ma Menghui;Lin Sheng;Li Xin;Shu Yue;Wang Ziwei;Zhou Yuhang;Hu Banglian;Cheng Baoying;Duan Shengshun;Huang Xiaohua;Xu Huaxi;Zhang Yun-Wu;Zheng Honghua |
| 3 | Neuron-Specific Menin Deletion Leads to Synaptic Dysfunction and Cognitive Impairment by Modulating p35 Expression | 期刊论文 | Zhuang Kai;Huang Changquan;Leng Lige;Zheng Honghua;Gao Yuehong;Chen Guimiao;Ji Zhilin;Sun Hao;Hu Yu;Wu Di;Shi Meng;Li Huifang;Zhao Yingjun;Bu Guojun;Xu Huaxi;Zhang Jie;Zhao Yingjun;Zhang Yunwu;Huang Timothy Y.;Xu Huaxi;Xue Maoqiang;Bu Guojun;Zhang J |
| 4 | Protective Role of L-3-n-Butylphthalide in Cognitive Function and Dysthymic Disorders in Mouse With Chronic Epilepsy | 期刊论文 | Ye Xiaowen;Wang Xintian;Cheng Yiyun;Luo Haijuan;Liu Zhaoji;Zheng Weihong;Ye Xiaowen;Rong Zhouyi;Li Yanfang;Wang Xintian;Cheng Baoying;Cheng Yiyun;Luo Haijuan;Liu Zhaoji;Zhang Yun-wu;Zheng Honghua;Wang Xintian;Cheng Yiyun;Zheng Weihong;Ti Yue;Zheng Weihong;Huang Xiaohua;Zheng Honghua;Zheng Honghua;Zheng WH;Zheng HH;Zheng WH;Zheng WH;Zheng HH;Zheng HH |
| 5 | Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Interacts With Colony-Stimulating Factor 1 Receptor (CSF1R) but Is Not Necessary for CSF1/CSF1R-Mediated Microglial Survival | 期刊论文 | Cheng Baoying;Li Xin;Dai Kai;Duan Shengshun;Rong Zhouyi;Chen Yingmin;Lu Liangcheng;Liu Zhaoji;Huang Xiaohua;Xu Huaxi;Zhang Yun-Wu;Zheng Honghua |
| 6 | Activation of FAK/Rac1/Cdc42-GTPase signaling ameliorates impaired microglial migration response to A beta(42)in triggering receptor expressed on myeloid cells 2 loss-of-function murine models | 期刊论文 | Rong Zhouyi;Cheng Baoying;Zhong Li;Ye Xiaowen;Li Xin;Jia Lin;Li Yanfang;Shue Francis;Wang Na;Cheng Yiyun;Huang Xiaohua;Liu Chia-Chen;Fryer John D.;Wang Xin;Zhang Yun-wu;Zheng Honghua |
| 7 | Silencing MicroRNA-155 Attenuates Kainic Acid-Induced Seizure by Inhibiting Microglia Activation | 期刊论文 | Fu Huajun;Cheng Yiyun;Luo Haijuan;Rong Zhouyi;Li Yanfang;Lu Ping;Ye Xiaowen;Huang Weiyan;Qi Ziguo;Li Xiuying;Cheng Baoying;Wang Xintian;Yao Yi;Zhang Yun Wu;Zheng Weihong;Zheng Honghua |
| 8 | Compensatory Mechanisms Modulate the Neuronal Excitability in a Kainic Acid-Induced Epilepsy Mouse Model | 期刊论文 | Pan Gaojie;Chen Zhicai;Zheng Honghua;Zhang Yunwu;Xu Huaxi;Bu Guojun;Li Yanfang;Xu Huaxi;Bu Guojun;Zheng Hui;Li YF |
| 9 | TREM2 in Alzheimer's Disease: Microglial Survival and Energy Metabolism | 期刊论文 | Zheng Honghua;Cheng Baoying;Li Yanfang;Li Xin;Chen Xiaofen;Zhang Yun wu |
| 10 | A brain somatic RHEB doublet mutation causes focal cortical dysplasia type II | 期刊论文 | Zhao Shanshan;Li Zhenghui;Zhang Muxian;Zhang Lingliang;Zheng Honghua;Ning Jinhuan;Wang Yanyan;Wang Fengpeng;Zhang Xiaobin;Gan Hexia;Wang Yuanqing;Zhang Xian;Luo Hong;Bu Guojun;Xu Huaxi;Yao Yi;Zhang Yun wu |
| 11 | Identification of a Novel Hemizygous SQSTM1 Nonsense Mutation in Atypical Behavioral Variant Frontotemporal Dementia | 期刊论文 | Sun Lin;Li Wei;Xiao Shifu;Li Xia;Rong Zhouyi;Zheng Honghua;Zheng Honghua;Xiao SF;Li X;Zheng HH;Zheng HH |
| 12 | ErbB4 Mutation that Decreased NRG1-ErbB4 Signaling Involved in the Pathogenesis of Amyotrophic Lateral Sclerosis/Frontotemporal Dementia | 期刊论文 | Sun Lin;Cheng Baoying;Zhou Yuxun;Fan Yating;Li Wei;Qiu Qi;Fang Yuan;Xiao Shifu;Zheng Honghua;Li Xia |
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