阿帕替尼抑制FLT3/STAT5通路优先杀伤FLT3-ITD阳性急性髓系白血病的研究
81700161
2017
H0809.白血病
邓漫漫
青年科学基金项目
主治医师
厦门大学
20万元
急性髓系白血病;FLT3/STAT5;阿帕替尼;FLT3-ITD
2018-01-01到2020-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Combining triptolide with ABT-199 is effective against acute myeloid leukemia through reciprocal regulation of Bcl-2 family proteins and activation of the intrinsic apoptotic pathway | 期刊论文 | Yuanfei Shi;Long Liu;Lingli He;Jing Ye;Zhijuan Lin;Delin Yuan;Manman Deng;Zhihong Fang;Bing Z Carter;Bing Xu |
| 2 | Apatinib exhibits anti-leukemia activity in preclinical models of acute lymphoblastic leukemia | 期刊论文 | Deng Manman;Zha Jie;Jiang Zhiwu;Jia Xian;Shi Yuanfei;Li Peng;Chen Xiao Lei;Fang Zhihong;Du Zhiqiang;Xu Bing |
| 3 | CS2164 exerts an antitumor effect against human Non-Hodgkin's lymphomas in vitro and in vivo | 期刊论文 | Deng Manman;Shi Yuanfei;Chen Kai;Zhao Haijun;Wang Yan;Xie Siting;Zhao Jintao;Luo Yiming;Fang Zhihong;Fan Yaqun;Xu Bing |
| 4 | Apatinib exerts anti-tumor activity to non-Hodgkin lymphoma by inhibition of the Ras pathway | 期刊论文 | Wang Yan;Deng Manman;Chen Qinwei;Li Yin;Guo Xutao;Shi Pengcheng;He Lingli;Xie Siting;Yu Lian;Zhang Haiping;Xu Bing |
| 5 | Apatinib exhibits cytotoxicity toward leukemia cells by targeting VEGFR2-mediated prosurvival signaling and angiogenesis | 期刊论文 | Deng Manman;Zha Jie;Zhao Haijun;Jia Xian;Shi Yuanfei;Li Zhifeng;Fu Guo;Yu Lian;Fang Zhihong;Xu Bing |
| 6 | CS2164 suppresses acute myeloid leukemia cell growth via inhibiting VEGFR2 signaling in preclinical models | 期刊论文 | Deng Manman;Zhao Haijun;Chen Qinwei;Zhao Jintao;Shi Yuanfei;Yu Lian;Fang Zhihong;Xu Bing |
| 7 | Napabucasin (BBI608) eliminate AML cells in vitro and in vivo via inhibition of Stat3 pathway and induction of DNA damage | 期刊论文 | Bi Silei;Chen Kai;Feng Liying;Fu Guofeng;Yang Qianying;Deng Manman;Zhao Haijun;Li Zhifeng;Yu Lian;Fang Zhihong;Xu Bing |
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