基于磷脂酶Cγ的自噬/凋亡拮抗调节对骨性关节炎软骨基质稳态的调控

81572189
2015
H0608.骨、关节、软组织退行性病变
夏春
面上项目
教授
厦门大学
57万元
软骨细胞凋亡;骨性关节炎;磷脂酶Cγ;基质稳态;软骨细胞自噬
2016-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 厦门市科学技术奖 奖励 夏春;张兵;胡天惠;宋刚;高丰光;郑欣鹏;赵洪海
2 DAG/PKCδ and IP3/Ca2+/CaMK IIβ Operate in Parallel to Each Other in PLCγ1-Driven Cell Proliferation and Migration of Human Gastric Adenocarcinoma Cells, through Akt/mTOR/S6 Pathway 期刊论文 Lianzhi Dai;Luhua Zhuang;Bingchang Zhang;Fen Wang;Xiaolei Chen;Chun Xia;Bing Zhang
3 Intra-articular Injection of Kartogenin-Incorporated Thermogel Enhancing Osteoarthritis Treatment 期刊论文 Wang Shao Jie;Qin Ji Zheng;Zhang Tong En;Xia Chun
4 Phosphoinositide-specific phospholipase C gamma 1 inhibition induces autophagy in human colon cancer and hepatocellular carcinoma cells 期刊论文 Dai Lianzhi;Chen Xiaolei;Lu Xiaohong;Wang Fen;Zhan Yanyan;Song Gang;Hu Tianhui;Xia Chun;Zhang Bing
5 Overexpression of microRNA-634 suppressessurvival and matrix synthesis of human osteoarthritis chondrocytes by targetingPIK3R1. 期刊论文 Xu Cui;Shaojie Wang;Heguo Cai;Yuan Lin;Xinpeng Zheng;Bing Zhang;Chun Xia
6 IL-1 beta receptor antagonist (IL-1Ra) combined with autophagy inducer (TAT-Beclin1) is an effective alternative for attenuating extracellular matrix degradation in rat and human osteoarthritis chondrocytes 期刊论文 Wang Fen;Liu Jijie;Chen Xiaolei;Zheng Xinpeng;Qu Ning;Zhang Bing;Xia Chun
7 Different roles of Akt and mechanistic target of rapamycin in serum‑dependent chondroprotection of human osteoarthritic chondrocytes 期刊论文 Tongen Zhang;Jijie Liu;Xinpeng Zheng;Bing Zhang;Chun Xia
8 关节镜下后交叉韧带重建胫骨隧道牵引线导向套管 专利 王少杰;夏春
9 The inhibition of PLCγ1 protects chondrocytes against osteoarthritis, implicating its binding to Akt. 期刊论文 Heguo Cai;Ning Qu;Xiaolei Chen;Yang Zhou;Xinpeng Zheng;Bing Zhang;Chun Xia
10 Chondroprotection of PPAR alpha activation by WY14643 via autophagy involving Akt and ERK in LPS-treated mouse chondrocytes and osteoarthritis model 期刊论文 Zhou Yang;Chen Xiaolei;Qu Ning;Zhang Bing;Xia Chun
11 一种微创人工膝关节置换术用撬板 专利 夏春;王少杰
12 Lentivirus-mediated PLC gamma 1 gene short-hairpin RNA suppresses tumor growth and metastasis of human gastric adenocarcinoma 期刊论文 Zhang Bingchang;Wang Fen;Dai Lianzhi;Cai Heguo;Zhan Yanyan;Gang Song;Hu Tianhui;Xia Chun;Zhang Bing
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