针对心室重构关键靶点的新型核素探针构建与显像研究
81471707
2014
H2706.分子影像
张现忠
面上项目
教授
厦门大学
73万元
分子影像;GLP-1受体;放射性探针;心室重构;CXCR4受体
2015-01-01到2018-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Superfluorinated PEI Derivative Coupled with (99m) Tc for ASGPR Targeted (19) F MRI/SPECT/PA Tri-Modality Imaging. | 期刊论文 | Guo Zhide;Gao Mengna;Song Manli;Li Yesen;Zhang Deliang;Xu Duo;You Linyi;Wang Liangliang;Zhuang Rongqiang;Su Xinhui;Liu Ting;Du Jin;Zhang Xianzhong |
| 2 | Radioiodinated Portable Albumin Binder as a Versatile Agent for in vivo Imaging with Single-Photon Emission Computed Tomography | 期刊论文 | Wen Xuejun;Shi Changrong;Xu Duo;Zhang Pu Zhang;Li Zizhen;Li Jindian;Su Xinhui;Zhuang Rongqiang;Liu Ting;Guo Zhide;Zhang Xianzhong |
| 3 | Synthesis and Bio-Evaluation of New F-18-Labeled Pyridaben Analogs with Improved Stability for Myocardial Perfusion Imaging in Mice | 期刊论文 | Mou Tiantian;Zhao Zuoquan;Zhang Pu;Fang Wei;Peng Cheng;Lu Jie;Wang Qian;Ma Yunchuan;Zhang Xianzhong |
| 4 | Syntheses and preliminary evaluation of [F-18]AlF-NOTA-G-TMTP1 for PET imaging of high aggressive hepatocellular carcinoma | 期刊论文 | Li Yesen;Zhang Deliang;Shi Ying;Guo Zhide;Wu Xinying;Ren Jian-Lin;Zhang Xianzhong;Wu Hua |
| 5 | Radioiodinated Pentixather for SPECT Imaging of Expression of the Chemokine Receptor CXCR4 in Rat Myocardial-Infarction-Reperfusion Models | 期刊论文 | Li Jindian;Peng Chenyu;Guo Zhide;Shi Changrong;Zhuang Rongqiang;Hong Xingfang;Wang Xiangyu;Xu Duo;Zhang Pu;Zhang Deliang;Liu Ting;Su Xinhui;Zhang Xianzhong |
| 6 | Highly Efficient and Stable Strain-Release Radioiodination for Thiol Chemoselective Bioconjugation. | 期刊论文 | Zhang Pu;Zhuang Rongqiang;Wang Xiangyu;Liu Huanhuan;Li Jindian;Su Xinhui;Chen Xiaoyuan;Zhang Xianzhong |
| 7 | MicroSPECT imaging of triple negative breast cancer cell tumor xenografted in athymic mice with radioiodinated anti-ICAM-1 monoclonal antibody | 期刊论文 | You Linyi;Wang Xiangyu;Guo Zhide;Zhang Deliang;Zhang Pu;Li Jindian;Su Xinhui;Pan Wenmin;Zhang Xianzhong |
| 8 | Peptide-based imaging agents for cancer detection | 期刊论文 | Sun Xiaolian;Li Yesen;Liu Ting;Li Zijing;Zhang Xianzhong;Chen Xiaoyuan |
| 9 | (18)F-Labeled Benzyldiamine Derivatives as Novel Flexible Probes for Positron Emission Tomography of Cerebral β-Amyloid Plaques | 期刊论文 | Li Zijing;Zhang Xuran;Zhang Xiaoyang;Cui Mengchao;Lu Jie;Pan Xiaodong;Zhang Xianzhong |
| 10 | Highly Specific and Sensitive Radioiodinated Agent for In Vivo Imaging of Superoxide through Superoxide-Initiated Retention | 期刊论文 | Huang Lumei;Li Zijing;Zhang Deliang;Li Hua;Shi Changrong;Zhang Pu;Su Xinhui;Zhang Xianzhong |
| 11 | Radioiodinated Small-Molecule Tyrosine Kinase Inhibitor for HER2-Selective SPECT Imaging | 期刊论文 | Tang Longguang;Peng Chenyu;Tang Bowen;Li Zijing;Wang Xiangyu;Li Jindian;Gao Fei;Huang Lumei;Xu Duo;Zhang Pu;Zhuang Rongqiang;Su Xinhui;Chen Xiaoyuan;Zhang Xianzhong |
| 12 | (18)F-labeled estradiol derivative for targeting estrogen receptor-expressing breast cancer. | 期刊论文 | Xu Duo;Zhuang Rongqiang;You Linyi;Guo Zhide;Wang Xiangyu;Peng Chenyu;Zhang Deliang;Zhang Pu;Wu Hua;Pan Weimin;Zhang Xianzhong |
| 13 | Synthesis and preliminary evaluation of a (18) F-labeled ethisterone derivative [(18) F]EAEF for progesterone receptor targeting. | 期刊论文 | Wu Xiaowei;You Linyi;Zhang Deliang;Gao Mengna;Li Zijing;Xu Duo;Zhang Pu;Huang Lumei;Zhuang Rongqiang;Wu Hua;Zhang Xianzhong |
| 14 | 一种超氧阴离子探针及其制备方法和应用 | 专利 | 张现忠;黄路梅;李子婧;张德良;李化 |
| 15 | Synthesis and bioevaluation of 4-chloro-2-tert-butyl-5-[2-[[1-[2-[F-18]fluroethyl]-1H-1,2,3-triazol-4-y l]methyl]phenylmethoxy]-3(2H)-pyridazinone as potential myocardial perfusion imaging agent with PET | 期刊论文 | Mou Tiantian;Zhao Zuoquan;You Linyi;Wang Qian;Fang Wei;Lu Jie;Peng Cheng;Zhang Xianzhong |
| 16 | A Highly Efficient Copper-Mediated Radioiodination Approach Using Aryl Boronic Acids | 期刊论文 | Zhang Pu;Zhuang Rongqiang;Guo Zhide;Su Xinhui;Chen Xiaoyuan;Zhang Xianzhong |
| 17 | Synthesis and Evaluation of Tc-99m-Labeled Dimeric Folic Acid for FR-Targeting | 期刊论文 | Guo Zhide;Gao Mengna;Song Manli;Shi Changrong;Zhang Pu;Xu Duo;You Linyi;Zhuang Rongqiang;Su Xinhui;Liu Ting;Du Jin;Zhang Xianzhong |
| 18 | 受体类分子靶向显像剂及其制备方法和应用 | 专利 | 张现忠;许多;庄荣强;尤林怡;郭志德;张德良;张蒲 |
| 19 | Research Progress on F-18-Labeled Agents for Imaging of Myocardial Perfusion with Positron Emission Tomography | 期刊论文 | Mou Tiantian;Zhang Xianzhong |
| 20 | Synthesis and Evaluation of 18F-labeled Pyridaben Analogues for Myocardial Perfusion Imaging in Mice, Rats and Chinese mini-swine | 期刊论文 | Mou Tiantian;Zhao Zuoquan;You Linyi;Li Yesen;Wang Qian;Fang Wei;Lu Jie;Peng Cheng;Zhang Xianzhong |
| 21 | Highly specific C-C bond cleavage induced FRET fluorescence for in vivo biological nitric oxide imaging. | 期刊论文 | Li Hua;Zhang Deliang;Gao Mengna;Huang Lumei;Tang Longguang;Li Zijing;Chen Xiaoyuan;Zhang Xianzhong |
| 22 | Simultaneous SPECT imaging of multi-targets to assist in identifying hepatic lesions | 期刊论文 | Guo Zhide;Gao Mengna;Zhang Deliang;Li Yesen;Song Manli;Zhuang Rongqiang;Su Xinhui;Chen Guibing;Liu Ting;Liu Pingguo;Wu Hua;Du Jin;Zhang Xianzhong |
| 23 | pH-Sensitive Radiolabeled and Superfluorinated Ultra-Small Palladium Nanosheet as a High-Performance Multimodal Platform for Tumor Theranostics | 期刊论文 | Guo Zhide;Chen Mei;Peng Chenyu;Mo Shiguang;Shi Changrong;Fu Guifeng;Wen Xuejun;Zhuang Rongqiang;Su Xinhui;Liu Ting;Zheng Nanfeng;Zhang Xianzhong |
| 24 | 诊断用放射性药物研究现状与展望 | 期刊论文 | 尤林怡;郭志德;张现忠 |
| 25 | Development of a New FR-Targeting Agent (99m)Tc-HYNFA with Improved Imaging Contrast and Comparison of Multimerization and/or PEGylation Strategies for Radio-Folate Modification. | 期刊论文 | Guo Zhide;You Linyi;Shi Changrong;Song Manli;Gao Mengna;Xu Duo;Peng Chenyu;Zhuang Rongqiang;Liu Ting;Su Xinhui;Du Jin;Zhang Xianzhong |
| 26 | Development of a novel (99m) Tc-labelled small molecular antagonist for CXCR4 positive tumor imaging. | 期刊论文 | Zhang Xuran;You Linyi;Chen Shuting;Gao Mengna;Guo Zhide;Du Jin;Lu Jie;Zhang Xianzhong |
| 27 | 一种放射性碘标记方法 | 专利 | 张现忠;张蒲;庄荣强;郭志德 |
| 28 | 放射性核素标记的苯并喋啶类衍生物及其制备和应用 | 专利 | 张现忠;李进典;郭志德;石昌荣;彭晨钰;文雪君;高菲 |
| 29 | Pd nanosheets with their surface coordinated by radioactive iodide as a high- performance theranostic nanoagent for orthotopic hepatocellular carcinoma imaging and cancer therapy | 期刊论文 | Chen Mei;Guo Zhide;Chen Qinghua;Wei Jingping;Li Jingchao;Shi Changrong;Xu Duo;Zhou Dawang;Zhang Xianzhong;Zheng Nanfeng |
| 30 | 一种放射性碘标记的蛋白结合配体及其应用 | 专利 | 张现忠;文雪君;郭志德;张蒲;石昌荣;李进典;许多 |
| 31 | Simplified quantification method for in vivo SPECT/CT imaging of asialoglycoprotein receptor with Tc-99m-p(VLA-co-VNI) to assess and stage hepatic fibrosis in mice | 期刊论文 | Zhang Deliang;Guo Zhide;Zhang Pu;Li Yesen;Su Xinhui;You Linyi;Gao Mengna;Liu Chang;Wu Hua;Zhang Xianzhong |
| 32 | Synthesis and preliminary evaluation of a (99m) Tc-labeled folate-PAMAM dendrimer for FR imaging. | 期刊论文 | Song Manli;Guo Zhide;Gao Mengna;Shi Changrong;Xu Duo;You Linyi;Wu Xiaowei;Su Xinhui;Zhuang Rongqiang;Pan Weimin;Liu Ting;Zhang Xianzhong |
| 33 | Desmin- and vimentin-mediated hepatic stellate cell-targeting radiotracer Tc-99m-GlcNAc-PEI for liver fibrosis imaging with SPECT | 期刊论文 | Zhang Deliang;Zhuang Rongqiang;Guo Zhide;Gao Mengna;Huang Lumei;You Linyi;Zhang Pu;Li Jindian;Su Xinhui;Wu Hua;Chen Xiaoyuan;Zhang Xianzhong |
| 34 | 一种核素标记的靶向探针化合物及其制备方法 | 专利 | 张现忠;张德良;庄荣强;郭志德 |
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