活化的PLC-γ及与Akt关联调控OA软骨基质代谢的机制研究

81371952
2013
H0604.骨、关节、软组织损伤与修复
夏春
面上项目
教授
厦门大学
70万元
活化作用;代谢;骨性关节炎软骨基质;蛋白激酶B;磷脂酶C-gamma
2014-01-01到2017-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 莫诺苷在制备治疗骨性关节炎药物中的应用 专利 夏春;张兵
2 Overexpression of microRNA-634 suppressessurvival and matrix synthesis of human osteoarthritis chondrocytes by targetingPIK3R1. 期刊论文 Xu Cui;Shaojie Wang;Heguo Cai;Yuan Lin;Xinpeng Zheng;Bing Zhang;Chun Xia
3 The Involvement of Mutual Inhibition of ERK and mTOR in PLCγ1-Mediated MMP-13 Expression in Human Osteoarthritis Chondrocytes 期刊论文 Zejun Liu;Heguo Cai;Xinpeng Zheng;Bing Chang;Chun Xia
4 Lentivirus-mediated PLC gamma 1 gene short-hairpin RNA suppresses tumor growth and metastasis of human gastric adenocarcinoma 期刊论文 Zhang Bingchang;Wang Fen;Dai Lianzhi;Cai Heguo;Zhan Yanyan;Gang Song;Hu Tianhui;Xia Chun;Zhang Bing
5 Metastasis of human gastric adenocarcinoma partly depends on phosphoinositide-specific phospholipase gamma 1 expression 期刊论文 Zhuang Luhua;Zhang Bingchang;Zeng Guoqing;Dai Lianzhi;Qian Hongliu;Hu Tianhui;Song Gang;Zhang Bing;Xia Chun
6 DAG/PKCδ and IP3/Ca2+/CaMK IIβ Operate in Parallel to Each Other in PLCγ1-Driven Cell Proliferation and Migration of Human Gastric Adenocarcinoma Cells, through Akt/mTOR/S6 Pathway 期刊论文 Lianzhi Dai;Luhua Zhuang;Bingchang Zhang;Fen Wang;Xiaolei Chen;Chun Xia;Bing Zhang
7 Different roles of Akt and mechanistic target of rapamycin in serum‑dependent chondroprotection of human osteoarthritic chondrocytes 期刊论文 Tongen Zhang;Jijie Liu;Xinpeng Zheng;Bing Zhang;Chun Xia
8 Protein kinase B and extracellular signal-regulated kinase contribute to the chondroprotective effect of morroniside on osteoarthritis chondrocytes. 期刊论文 Liang Cheng;Guoqing Zeng;Zejun Liu;Bing Zhang;Xu Cui;Honghai Zhao;Xinpeng Zheng;Gang Song;JIang Kang;Chun Xia
9 Disruption of Phosphoinositide-Specific Phospholipases C gamma 1 Contributes to Extracellular Matrix Synthesis of Human Osteoarthritis Chondrocytes 期刊论文 Zeng Guoqing;Cui Xu;Liu Zejun;Zhao Honghai;Zheng Xinpeng;Zhang Bing;Xia Chun
10 Berberine ameliorates cartilage degeneration in interleukin-1 beta-stimulated rat chondrocytes and in a rat model of osteoarthritis via Akt signalling 期刊论文 Zhao Honghai;Zhang Tongen;Xia Chun;Shi Lei;Wang Shaojie;Zheng Xinpeng;Hu Tianhui;Zhang Bing
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