黄连素通过视黄醇X受体抑制肠癌生长机制的结构生物学分析和相应药物改造

U1405228
2014
H1802.肿瘤发生
胡天惠
联合基金项目
教授
厦门大学
255万元
药物改造;结构生物学;肠癌;视黄醇X受体;黄连素
2015-01-01到2018-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 The crystal structure of Ac-AChBP in complex with alpha-conotoxin LvIA reveals the mechanism of its selectivity towards different nAChR subtypes 期刊论文 Xu Manyu;Zhu Xiaopeng;Yu Jinfang;Yu Jinpeng;Luo Sulan;Wang Xinquan
2 Enantioselective total synthesis of periconiasin A 期刊论文 Yandong Zhang
3 Cycloaddition/annulation strategies for the construction of multisubstituted pyrrolidines and their applications in natural product synthesis 期刊论文 Jundong Li;Yilin Ye;Yandong Zhang
4 Asymmetric Total Synthesis of (+)-Majusculoic Acid via a Dimerization−Dedimerization Strategy and Absolute Configuration Assignment 期刊论文 Yandong Zhang
5 Exo70 is transcriptionally up-regulated by hepatic nuclear factor 4α and contributes to cell cycle control in hepatoma cells 期刊论文 Zhao YJ;Hou JH;Mi PY;Mao LY;Xu L;Zhang YY;Xiao L;Cao HW;Zhang WQ;Zhang B;Song G;Hu TH;Zhan YY
6 High expression of Tob1 indicates poor survival outcome and promotes tumour progression via a Wnt positive feedback loop in colon cancer 期刊论文 Dandan Li;Li Xiao;Yuetan Ge;Yu Fu;Wenqing Zhang;Hanwei Cao;Binbin Chen;Haibin Wang;Yanyan Zhan;Tianhui Hu
7 Asymmetric Total Synthesis of (+)-Majusculoic Acid via a Dimerization−Dedimerization Strategy and Absolute Configuration Assignment 期刊论文 Yandong Zhang
8 Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27. 期刊论文 Yu Xiaojuan;Zhang Senyan;Jiang Liwei;Cui Ye;Li Dongxia;Wang Dongli;Wang Nianshuang;Fu Lili;Shi Xuanlin;Li Ziqiang;Zhang Linqi;Wang Xinquan
9 Berberine inhibits colitis-associated tumorigenesis via suppressing inflammatory responses and the consequent EGFR signaling-involved tumor cell growth 期刊论文 Li Dandan;Zhang Youyu;Liu Kun;Zhao Yujie;Xu Beibei;Xu Liang;Tan Li;Tian Yuan;Li Cunxi;Zhang Wenqing;Cao Hanwei;Zhan Yan-yan;Hu Tianhui
10 Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein. 期刊论文 Shenyan Zhang;Panpan Zhou;Pengfei Wang;Yangyang Li;Liwei Jiang;Wenxu Jia;Han Wang;Angela Fan;Dongli Wang;Xuanling Shi;Xianyang Fang;Michal Hammel;Shuying Wang;Xinquan Wang;Linqi Zhang
11 Complementary recognition of the receptor-binding site of highly pathogenic H5N1 influenza viruses by two human neutralizing antibodies 期刊论文 Yanan Zuo;Pengfei Wang;Jianfeng Sun;Shichun Guo;Guiqin Wang;Teng Zuo;Shilong Fan;Paul Zhou;Mifang Liang;Xuanling Shi;Xinquan Wang;Linqi Zhang
12 Exo70 is an independent prognostic factor in colon cancer 期刊论文 Li Xiao;Kaifeng Zheng;Xia Lv;Jihuan Hou;Liang Xu;Yujie Zhao;Fei Song;Yaqiong Fan;Hanwei Cao;Wenqing Zhang;Xiaoting Hong;Yanyan Zhan;Tianhui Hu
13 Matrine induces RIP3-dependent necroptosis in cholangiocarcinoma cells 期刊论文 Xu BB;Xu MY;Tian Y;Yu Q;Zhao YJ;Chen X;Mi PY;Cao HW;Zhang B;Song G;Zhan YY;Hu TH
14 Total Synthesis of Aplydactone by a Conformationally Controlled C-H Functionalization 期刊论文 Yandong Zhang
15 Comprehensive analysis of antibody recognition in convalescent humans from highly pathogenic avian influenza H5N1 infection. 期刊论文 Zuo Teng;Sun Jianfeng;Wang Guiqin;Jiang Liwei;Zuo Yanan;Li Danyang;Shi Xuanling;Liu Xi;Fan Shilong;Ren Huanhuan;Hu Hongxing;Sun Lina;Zhou Boping;Liang Mifang;Zhou Paul;Wang Xinquan;Zhang Linqi
16 Berberine binds RXR alpha to suppress beta-catenin signaling in colon cancer cells 期刊论文 Ruan H.;Zhan Y. Y.;Hou J.;Xu B.;Chen B.;Tian Y.;Wu D.;Zhao Y.;Zhang Y.;Chen X.;Mi P.;Zhang L.;Zhang S.;Wang X.;Cao H.;Zhang W.;Wang H.;Li H.;Su Y.;Zhang X. K.;Hu T.
17 Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding 期刊论文 Gui Miao;Song Wenfei;Zhou Haixia;Xu Jingwei;Chen Silian;Xiang Ye;Wang Xinquan
18 Synthesis of b-prolinols via [3+2] cycloaddition and one-pot programmed reduction: Valuable building blocks for polyheterocycles 期刊论文 Yandong Zhang
19 Total Synthesis of (+)-Fusarisetin A Driven by a One-Pot Four Reaction Process 期刊论文 Chenguang Liu;Zhixiong Zeng;Renzhi Chen;Xunjin Jiang;Xunjin Jiang;Yinglu Wang;Yinglu Wang;Yandong Zhang
20 Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2. 期刊论文 Wenfei Song;Miao Gui;Xinquan Wang;Ye Xiang
21 Protecting-Group-Free Total Synthesis of (-)-Jiadifenolide: Development of a [4 + 1] Annulation toward Multisubstituted Tetrahydrofurans. 期刊论文 Shen Y;Li LB;Pan ZS;Wang YL;Li JD;Wang KY;Wang XC;Zhang YY;Hu TH;Zhang YD
22 一种黄连素衍生物NBD-125及其应用 专利 胡天惠
23 一种黄连素衍生物XMU-Ber122 专利 胡天惠
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