基于FRET生物传感器改进嵌合抗原受体(CAR)-T细胞疗法
31971324
2019
C1008.生物与医学工程新技术新方法
孙洁
面上项目
研究员
浙江大学
58万元
蛋白质设计;动物细胞工程;免疫疗法;细胞治疗;嵌合抗原受体
2020-01-01到2023-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Integration of FRET and sequencing to engineer kinase biosensors from mammalian cell libraries | 期刊论文 | Longwei Liu;Praopim Limsakul;Xianhui Meng;Yan Huang;Reed E. S. Harrison;Tse-Shun Huang;Yiwen Shi;Yiyan Yu;Krit Charupanit;Sheng Zhong;Shaoying Lu;Jin Zhang;Shu Chien;Jie Sun;Yingxiao Wang |
| 2 | CD38-Specific CAR Integrated into CD38 Locus Driven by Different Promoters Causes Distinct Antitumor Activities of T and NK Cells | 期刊论文 | Chan Liao;Yajie Wang;Yanjie Huang;Yanting Duan;Yan Liang;Jiangqing Chen;Jie Jiang;Kai Shang;Chun Zhou;Ying Gu;Nan Liu;Xun Zeng;Xiaofei Gao;Yongmin Tang;Jie Sun |
| 3 | Cas9-Cleavage Sequences in Size-Reduced Plasmids Enhance Nonviral Genome Targeting of CARs in Primary Human T Cells | 期刊论文 | Ruirui Jing;Peng Jiao;Jiangqing Chen;Xianhui Meng;Xiaoyan Wu;Yanting Duan;Kai Shang;Liling Qian;Yanjie Huang;Junwei Liu;Tao Huang;Jin Jin;Wei Chen;Xun Zeng;Weiwei Yin;Xiaofei Gao;Chun Zhou;Michel Sadelain;Jie Sun |
| 4 | Exploiting Ca2+ signaling in T cells to advance cancer immunotherapy | 期刊论文 | Xianhui Meng;Xiaoyan Wu;Yuyuan Zheng;Kai Shang;Ruirui Jing;Peng Jiao;Chun Zhou;Jing Zhou;Jie Sun |
| 5 | Tuning the ignition of CAR: optimizing the affinity of scFv to improve CAR-T therapy | 期刊论文 | Yanting Duan;Ruoqi Chen;Yanjie Huang;Xianhui Meng;Jiangqing Chen;Chan Liao;Yongmin Tang;Chun Zhou;Xiaofei Gao;Jie Sun |
| 6 | Signaling Dynamics of TSHR-Specific CAR-T Cells Revealed by FRET-Based Biosensors | 期刊论文 | Jing Zhou;Jiangqing Chen;Yanjie Huang;Xiaofei Gao;Chun Zhou;Xianhui Meng;Jie Sun |
| 7 | Balancing activation and co-stimulation of CAR tunes signaling dynamics and enhances therapeutic potency | 期刊论文 | Yanting Duan;Jiangqing Chen;Xianhui Meng;Longwei Liu;Kai Shang;Xiaoyan Wu;Yajie Wang;Zihan Huang;Houyu Liu;Yanjie Huang;Chun Zhou;Xiaofei Gao;Yingxiao Wang;Jie Sun |
| 8 | Engineering Cytoplasmic Signaling of CD28ζ CARs for Improved Therapeutic Functions | 期刊论文 | Xianhui Meng;Ruirui Jing;Liling Qian;Chun Zhou;Jie Sun |
| 9 | Inserting EF1α-driven CD7-specific CAR at CD7 locus reduces fratricide and enhances tumor rejection | 期刊论文 | Jie Jiang;Jiangqing Chen;Chan Liao;Yanting Duan;Yajie Wang;Kai Shang;Yanjie Huang;Yongming Tang;Xiaofei Gao;Ying Gu;Jie Sun |
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