活细胞中低温激活TRPM8离子通道的分子机制
31971040
2019
C1105.整合生理学与整合生物学
杨帆
面上项目
研究员
浙江大学
59万元
冷激活;膜片钳;离子通道;通道门控;荧光非天然氨基酸
2020-01-01到2023-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel | 期刊论文 | Wenxuan Zhen;Zhijun Zhao;Shenghai Chang;Xiaoying Chen;Yangzhuoqun Wan;Fan Yang |
| 2 | De Novo Design of Peptidic Positive Allosteric Modulators Targeting TRPV1 with Analgesic Effects | 期刊论文 | Lizhen Xu;Heng Zhang;Yunfei Wang;Xiancui Lu;Zhenye Zhao;Cheng Ma;Shilong Yang;Vladimir Yarov-Yarovoy;Yuhua Tian;Jie Zheng;Fan Yang |
| 3 | Structure-guided peptide engineering of a positive allosteric modulator targeting the outer pore of TRPV1 for long-lasting analgesia | 期刊论文 | Heng Zhang;Jia-Jia Lin;Ya-Kai Xie;Xiu-Zu Song;Jia-Yi Sun;Bei-Lei Zhang;Yun-Kun Qi;Zhen-Zhong Xu;Fan Yang |
| 4 | Rational Design of a Modality-Specific Inhibitor of TRPM8 Channel against Oxaliplatin-Induced Cold Allodynia | 期刊论文 | Aierken Aerziguli;Xie Ya-Kai;Dong Wenqi;Apaer Abuliken;Lin Jia-Jia;Zhao Zihan;Yang Shilong;Xu Zhen-Zhong;Fan Yang |
| 5 | Molecular mechanism underlying modulation of TRPV1 heat activation by polyols | 期刊论文 | Yingying Nie;Yanxin Li;Lei Liu;Shouyan Ren;Yuhua Tian;Fan Yang |
| 6 | 一种抑制TRPM8的多肽及其用途 | 专利 | 杨帆;阿尔孜古丽•艾尔肯 |
| 7 | Endocannabinoid activation of the TRPV1 ion channel is distinct from activation by capsaicin | 期刊论文 | Yanxin Li;Xiaoying Chen;Yingying Nie;Yuhua Tian;Xian Xiao;Fan Yang |
| 8 | Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands | 期刊论文 | Nannan Su;Wenxuan Zhen;Heng Zhang;Lingyi Xu;Yitian Jin;Xiaoying Chen;Cheng Zhao;Qinrui Wang;Xinyan Wang;Shaowei Li;Han Wen;Wei Yang;Jiangtao Guo;Fan Yang |
| 9 | A paradigm of thermal adaptation in penguins and elephants by tuning cold activation in TRPM8 | 期刊论文 | Shilong Yang;Xiancui Lu;Yunfei Wang;Lizhen Xu;Xiaoying Chen;Fan Yang;Ren Lai |
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