外泌体作为circRNA的新型载体清除衰老细胞并延缓心脏衰老的策略及机制研究

91849122
2018
H0202.心肌损伤、修复、重构和再生
李杨欣
重大研究计划
教授
苏州大学
50万元
心脏特异性环状RNA敲除/过表达鼠;外泌体;衰老细胞;环状RNA;纳米材料
2019-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Stem cell-derived exosomes repair ischemic muscle injury by inhibiting the tumor suppressor Rb1-mediated NLRP3 inflammasome pathway. 期刊论文 Yanli Wang;Wenping Xie;Bin Liu;Hui Huang;Wei Luo;Yu Zhang;Xiangbin Pan;Xi-Yong Yu;Zhenya Shen;Yangxin Li
2 Letter by Li et al Regarding Article, “Dectin-1 Contributes to Myocardial Ischemia/Reperfusion Injury by Regulating Macrophage Polarization and Neutrophil Infiltration” 期刊论文 Yangxin Li;Zhenya Shen;Xi-yong Yu
3 Knockout of beta‐2 microglobulin reduces stem cell‐induced immune rejection and enhances ischaemic hindlimb repair via exosome/miR‐24/Bim pathway 期刊论文 Yuqing Zhang;Yanli Wang;Lianbo Shao;Xiangbin Pan;Chun Liang;Bin Liu;Yu Zhang;Wenping Xie;Bing Yan;Feng Liu;Xi‐yong Yu;Yangxin Li
4 Human Umbilical Cord Mesenchymal Stem Cell Derived Exosomes Delivered Using Silk Fibroin and Sericin Composite Hydrogel Promote Wound Healing. 期刊论文 Han Chaoshan;Liu Feng;Zhang Yu;Chen Wenjie;Luo Wei;Ding Fengzhi;Lu Lin;Wu Chengjie;Li Yangxin
5 Stem cell-derived exosomes prevent pyroptosis and repair ischemic muscle injury through a novel exosome/circHIPK3/ FOXO3a pathway 期刊论文 Yan Bing;Zhang Yu;Liang Chun;Liu Bin;Ding Fengzhi;Wang Yanli;Zhu Bao;Zhao Ranzun;Yu Xi-Yong;Li Yangxin
6 表观遗传药理学 专著 余细勇;汪园;张灵敏;铁璐;钟文彬;秦爱萍;李晓红;江雪燕;段大跃;雷和平;钟诗龙;温预关;张梅;代小艳;李琳琳;李松沛;李杨欣;杨宝学;张建业;刘寿平;胡文辉;李学军
7 Knockout of beta-2 microglobulin enhances cardiac repair by modulating exosome imprinting and inhibiting stem cell-induced immune rejection 期刊论文 Lianbo Shao;Yu Zhang;Xiangbin Pan;Bin Liu;Chun Liang;Yuqing Zhang;Yanli Wang;Bing Yan;Wenping Xie;Yi Sun;Zhenya Shen;Xiyong Yu;Yangxin Li
8 Delivery of miR-675 by stem cell-derived exosomes encapsulated in silk fibroin hydrogel prevents aging-induced vascular dysfunction in mouse hindlimb 期刊论文 Chaoshan Han;Jin Zhou;Bin Liu;Chun Liang;Xiangbin Pan;Yu Zhang;Yuqing Zhang;Yanli Wang;Lianbo Shao;Bao Zhu;Juanjuan Wang;Qian Yin;Xi-Yong Yu;Yangxin Li
9 人脐带间充质干细胞来源的外泌体通过circHIPK3促进心梗修复 期刊论文 张雨晴;王燕丽;严兵;张瑜;谢文萍;刘冯;李杨欣
10 CRISPR技术编辑并用IGF优化的异体间充质干细胞的制备方法及在治疗心梗中应用 专利 李杨欣;沈振亚;邵联波
11 Stem Cell-Derived Exosomes Prevent Aging-Induced Cardiac Dysfunction through a Novel Exosome/lncRNA MALAT1/NF-κB/TNF-α Signaling Pathway 期刊论文 Bao Zhu;Lulu Zhang;Chun Liang;Bin Liu;Xiangbin Pan;Yanli Wang;Yuqing Zhang;Yu Zhang;Wenping Xie;Bing Yan;Feng Liu;Hon-Kan Yip;Xi-yong Yu;Yangxin Li
12 The Influence of Sex on Cardiac Physiology and Cardiovascular Diseases. 期刊论文 Zhang Yu;Liu Bin;Zhao Ranzun;Zhang Saidan;Yu Xi-Yong;Li Yangxin
13 Inflammasomes as therapeutic targets in human diseases. 期刊论文 Li Yangxin;Huang Hui;Liu Bin;Zhang Yu;Pan Xiangbin;Yu Xi-Yong;Shen Zhenya;Song Yao-Hua
14 一种带有母系印记的温敏感外泌体体系及其制备方法和应用 专利 李杨欣;刘冯;沈振亚;张瑜
15 外泌体在胸主动脉夹层/动脉瘤中的作用 专利 李杨欣;刘冯;沈振亚;张瑜
16 丝素水凝胶包裹的过表达ncRNA的MSC外泌体制备方法与在抗后肢衰老中的应用 专利 李杨欣;韩超珊
17 多肽、重组DNA分子、重组载体、外泌体及其应用 专利 李杨欣;邵联波;沈振亚
18 温敏型壳聚糖水凝胶包封外泌体在缺血性疾病中的应用 期刊论文 刘冯;张瑜;王燕丽;骆威;韩超珊;李杨欣
19 Letter by Li et al Regarding Article, "Small Extracellular Microvesicles Mediated Pathological Communications Between Dysfunctional Adipocytes and Cardiomyocytes as a Novel Mechanism Exacerbating Ischemia/Reperfusion Injury in Diabetic Mice" 期刊论文 Li Yangxin;Ding Fengzhi;Shen Zhenya
20 Human umbilical cord mesenchymal stem cell derived exosomes encapsulated in functional peptide hydrogels promote cardiac repair 期刊论文 Han Chaoshan;Zhou Jin;Liang Chun;Liu Bin;Pan Xiangbin;Zhang Yu;Wang Yanli;Yan Bing;Xie Wenping;Liu Feng;Yu Xi Yong;Li Yangxin
21 缺血性心脏病干细胞治疗临床转化的关键技术创新 奖励 沈振亚;李杨欣;张浩;胡士军;陈一欢;余云生;滕小梅;陈红;刘盛;雷伟;张燕霞
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