RUNX1基因突变在BCR-ABL1阳性白血病中的致病机制及靶向治疗研究
81970142
2019
H0809.白血病
陈苏宁
面上项目
教授
苏州大学
55万元
BCR-ABL1;基因突变;致白血病机制;RUNX1;靶向治疗
2020-01-01到2023-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | A special type of chromosome 1 abnormality in myelodysplastic syndrome patients: duplication 1q | 期刊论文 | Yu Yan;Zhang Tongtong;Zeng Zhao;Wang Qinrong;Hong Yang;Shen Hongjie;Wu Depei;Pan Jinlan;Chen Suning;Sun Aining |
| 2 | Case Report: The Formation of a Truncated PAX5 Transcript in a Case of Ph-Positive Mixed Phenotype Acute Leukemia With dic(7;9)(p11-p13;p13) | 期刊论文 | Yan Yu;Zhao Zeng;Jundan Xie;Qiongyu Lu;Wenzhi Cai;Ruixi Zhang;Jinlan Pan;Yun Zhao;Aining Sun;Huiying Qiu;Suning Chen |
| 3 | Diagnosis and Treatment of Myeloproliferative Neoplasms With PCM1-JAK2 Rearrangement: Case Report and Literature Review. | 期刊论文 | Yingxin Sun;Yifeng Cai;Jia Chen;Jiannong Cen;Mingqing Zhu;Jinlan Pan;Depei Wu;Aining Sun;Suning Chen |
| 4 | Case Report: A novel FGFR1 fusion in acute B-lymphoblastic leukemia identified by RNA sequencing | 期刊论文 | Zhibo Zhang;Yiyan Zhu;Zheng Wang;Zhao Zeng;Lijun Wen;Ling Zhang;Suning Chen |
| 5 | 一种PDGFRB易位性血液病的融合基因及其检测引物和应用 | 专利 | 王征;许小宇;曾招;张灵;文丽君;陈苏宁;申真 |
| 6 | Identification of a Novel CSNK2A1-PDGFRB Fusion Gene in a Patient with Myeloid Neoplasm with Eosinophilia | 期刊论文 | Xiaoyu Xu;Qiongyu Lu;Zheng Wang;Ping Cai;Zhao Zeng;Ling Zhang;Man Wang;Liang Ma;Changgeng Ruan;Suning Chen |
| 7 | A Case With Philadelphia Chromosome Positive T-Cell Lymphoblastic Lymphoma and a Review of Literature. | 期刊论文 | Xuewei Li;Nana Ping;Yong Wang;Xiaoyu Xu;Lijuan Gao;Zhao Zeng;Ling Zhang;Zhibo Zhang;Yiyu Xie;Changgeng Ruan;Depei Wu;Zhengming Jin;Suning Chen |
| 8 | Molecular characterization and prognosis of mutant TP53 acute myeloid leukemia and myelodysplastic syndrome with excess blasts. | 期刊论文 | Kai Shen;De-Yuan Hu;Zhi-Bo Zhang;Yu-Sha Guo;Feng-Hong Zhang;Su-Ning Chen |
| 9 | Single-cell RNA-seq reveals the links between the metabolic heterogeneity and cell identity in NBM and AML | 期刊论文 | Qiongyu Lu;Wenqiang Qu;Yuxin Wen;Peng Ke;Luyao Zhao;Qingyuan Wang;Suning Chen;Zhao Zeng |
| 10 | Identification and validation of a 7-genes prognostic signature for adult acute myeloid leukemia based on aging-related genes. | 期刊论文 | Peng Ke;Qian Zhu;Ting Xu;Xiaofei Yang;Ying Wang;Huiying Qiu;Depei Wu;Depei Wu;Suning Chen |
| 11 | Exploration of efficacy and safety of combined therapy of basiliximab with ruxolitinib for grade 3-4 steroid-refractory acute graft-versus-host disease: a registered clinical trial (NCT05021276). | 期刊论文 | Fei Zhou;Tingting Pan;Xiaoli Li;Feng Du;Xiao Ma;Yanming Zhang;Depei Wu;Yue Han;Shengli Xue;Miao Miao;Tao Tao;Xuefeng He;Suning Chen |
| 12 | Recurrent mutations in multiple components of the SWI/SNF complex in myelodysplastic syndromes and acute myeloid leukaemia | 期刊论文 | Hong Yao;Li Huo;Nana Ping;Hong Liu;Hongzhi Li;Zixuan Ding;Hongjie Shen;Jundan Xie;Qiaocheng Qiu;Liang Ma;Airui Jiang;Qian Wang;Depei Wu;Xiaofei Yang;Yaohua Song;Suning Chen |
| 13 | Identification of a venetoclax-resistance prognostic signature base on 6-senescence genes and its clinical significance for acute myeloid leukemia. | 期刊论文 | Peng Ke;Jundan Xie;Ting Xu;Meiyu Chen;Yusha Guo;Ying Wang;Huiying Qiu;Depei Wu;Zhao Zeng;Suning Chen;Xiebing Bao |
| 14 | 一种CTCF-ETO2血液病的融合基因及其检测引物和应用 | 专利 | 王征;陈苏宁;文丽君 |
| 15 | Causative germline variant p.Y259C of DDX41 recurrently identified in acute lymphoblastic leukaemia. | 期刊论文 | Li Huo;Zhibo Zhang;Haixia Zhou;Jundan Xie;Airui Jiang;Qian Wang;Zixuan Ding;Haiping Dai;Dandan Liu;Ni Wu;Qiaocheng Qiu;Liang Ma;Man Wang;Wenjuan Wang;Shengli Xue;Zixing Chen;Depei Wu;Hong Yao;Suning Chen;Hongjie Shen |
| 16 | Identification of a novel TNRC18-RARA fusion in acute promyelocytic leukemia lacking t(15;17)(q24;q12)/PML-RARA | 期刊论文 | Wang Zheng;Wen Lijun;Zhang Ling;Xu Xiaoyu;Chen Xiaoqian;Yao Li;Wang Man;Shen Zhen;Mo Guangquan;Wang Yao;Zhao Dewan;Cai Wei;Shen Jingzhi;Chi Xiaomeng;Xu Yi;Zeng Zhao;Pan Jinlan;Ruan Changgeng;Wu Depei;Jia Zhilin;Chen Suning |
| 17 | A new breakpoint fusion gene involving KMT2A::EDC4 rearrangement in de novo acute myeloid leukemia | 期刊论文 | De-Yuan Hu;Man Wang;Kai Shen;Jin-Lan Pan;Yu-Sha Guo;Zhi-Bo Zhang;Feng-Hong Zhang;Jia Yin;Su-Ning Chen |
| 18 | Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition) | 期刊论文 | Suning Chen;Weili Zhao;Jianyong Li;Depei Wu |
| 19 | Identification of a novel TFG-FGFR1 fusion gene in an acute myeloid leukaemia patient with t(3;8)(q12;p11) | 期刊论文 | Wang Tingjing;Wang Zheng;Zhang Ling;Wen Lijun;Cai Wenzhi;Yang Xiaofei;Pan Jinlan;Ruan Changgeng;Wu Depei;Sun Aining;Chen Suning |
| 20 | TBL1XR1 mutation predicts poor outcome in primary testicular diffuse large B-cell lymphoma patients | 期刊论文 | Wang Xinfeng;Xu Xiaoyu;Cai Wenzhi;Bao Haiyan;Huang Hongming;Liu Yifei;Yang Xi;Ruan Changgeng;Wu Depei;Shen Hongjie;Chen Suning |
| 21 | Case Report: Off-label treatment of idiopathic hypereosinophilic syndrome with Omalizumab. | 期刊论文 | Zhiyu Zhang;Yingxin Sun;Su-Ning Chen |
| 22 | The efficacy of first salvage therapy determines the outcomes of adult patients with type 1 primary refractory acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation | 期刊论文 | Zhiyou Yu;Yao Yao;Yanming Zhang;Jia Chen;Yang Xu;Shengli Xue;Huiying Qiu;Xiaowen Tang;Yue Han;Suning Chen;Aining Sun;Depei Wu;Ying Wang |
| 23 | A multi-center retrospective comparison between systemic mastocytosis with t(8;21) AML and KIT mutant t(8;21) AML. | 期刊论文 | Zhibo Zhang;Jia Yin;Guoli Lian;Xiebing Bao;Meng Hu;Zhenfang Liu;Yuan Yu;Ruihua Mi;Yabei Zuo;Pengcheng Shi;Weiyan Zheng;Qian Jiang;Hongying Chao;Peifang Xiao;Weijuan Yu;Yanqiu Han;Yu Wu;Yan Zeng;Depei Wu;Xiaofei Yang;Suning Chen |
| 24 | An effective early death scoring system for predicting early death risk in de novo acute promyelocytic leukemia | 期刊论文 | Cai Ping;Wu Qian;Wang Yemin;Yang Xiaofei;Zhang Xinyou;Chen Suning |
| 25 | High expression of myocyte enhancer factor 2C predicts poor prognosis for adult acute myeloid leukaemia with normal karyotype. | 期刊论文 | Xiaoyu Xu;Xiaoyu Xu;Li Huo;Li Huo;Li Huo;Ling Zhang;Jiannong Cen;Huiying Qiu;Xiaowen Tang;Chengcheng Fu;Yue Han;Miao Miao;Zhengming Jin;Changgeng Ruan;Depei Wu;Suning Chen;Qingrong Wang;Lingzhi Yan |
| 26 | Prognostic Nomogram for Acute Myeloid Leukemia Patients With Biallelic CEBPA Mutations | 期刊论文 | Xu Xiaoyu;Cai Wenzhi;Cai Ping;Zhang Ling;Yao Hong;Zhang Tongtong;Shen Hongjie;Chen Suning |
| 27 | Integrative genomic and transcriptomic profiling reveals distinct molecular subsets in adult mixed phenotype acute leukemia | 期刊论文 | Qian Wang;Wen-Zhi Cai;Qin-Rong Wang;Ming-Qing Zhu;Ling-Zhi Yan;Yan Yu;Xie-Bing Bao;Hong-Jie Shen;Hong Yao;Jun-Dan Xie;Tong-Tong Zhang;Ling Zhang;Xiao-Yu Xu;Zhe Shan;Hong Liu;Jian-Nong Cen;Dan-Dan Liu;Jin-Lan Pan;Da-Ru Lu;Jia Chen;Yang Xu;Ri Zhang;Ying Wang;Sheng-Li Xue;Miao Miao;Yue Han;Xiao-Wen Tang;Hui-Ying Qiu;Ai-Ning Sun;Jin-Yan Huang;Hai-Ping Dai;De-Pei Wu;Su-Ning Chen |
| 28 | Effective treatment with Gilteritinib-based regimens for FLT3-mutant extramedullary relapse in acute promyelocytic leukemia | 期刊论文 | Chun-Xiao Hou;Yu Chen;Shan-Hao Liu;Yi-Zhi Jiang;Dong-Ping Huang;Su-Ning Chen |
| 29 | Venetoclax with decitabine as frontline treatment in younger adults with newly diagnosed ELN adverse-risk AML | 期刊论文 | Jundan Xie;Xiebing Bao;Sheng-Li Xue;Hongjie Shen;Jiannong Cen;Li Yao;Jinlan Pan;Mingqing Zhu;Dandan Liu;Xiaohui Hu;Qian Wu;Jingren Zhang;Haiping Dai;Yanglin Cao;Xuefeng He;Xiaowen Tang;Ai-Ning Sun;Ying Wang;Jianhong Fu;Huiying Qiu;Xiaofei Yang;Suning Chen;Depei Wu |
| 30 | A global study for acute myeloid leukemia with RARG rearrangement. | 期刊论文 | Hong-Hu Zhu;Ya-Zhen Qin;Zhang-Lin Zhang;Yong-Jing Liu;Li-Jun Wen;Jin-Yan Huang;Jiong Hu;Suning Chen |
| 31 | A Recurrent Cryptic MED14-HOXA9 Rearrangement in an Adult Patient With Mixed-Phenotype Acute Leukemia, T/myeloid, NOS | 期刊论文 | Qian Wang;Ling Zhang;Ming-qing Zhu;Zhao Zeng;Bao-zhi Fang;Jun-dan Xie;Jin-lan Pan;Chun-xiao Wu;Ni Wu;Ri Zhang;Su-ning Chen;Hai-ping Dai |
| 32 | Identification of a novel ETV6 truncated fusion gene in myeloproliferative neoplasm, unclassifiable with t(4;12)(q12;p13) | 期刊论文 | Ling Zhang;Man Wang;Zheng Wang;Zhao Zeng;Lijun Wen;Yi Xu;Li Yao;Jiannong Cen;Hongzhi Li;Jinlan Pan;Aining Sun;Depei Wu;Suning Chen;Liang Ma;Xiaofei Yang |
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