基于FLT3新型结构模型筛选优化特异性抑制小分子化合物及其抗急性髓系白血病的活性研究

81970138
2019
H0809.白血病
薛胜利
面上项目
教授
苏州大学
55万元
急性髓系白血病;活性验证;小分子筛选;靶向治疗;FLT3
2020-01-01到2023-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 双表观预激方案治疗成人复发难治性急性髓系白血病的临床研究 会议论文 薛胜利;万超玲;尹佳;张灵;白莲;张颢;张彦明;周海侠;陈丽韵;徐明珠;孙爱宁;吴德沛
2 Maintenance Therapy with Chidamide Plus Azacitidine after Allogeneic Hematopoietic Stem Cell Transplantation for High-Risk Acute Myeloid Leukemia Patients 会议论文 Xiaohui Hu;Depei Wu;Suning Chen;Yaxue Wu;Yang Zhang;Lian Bai;Bing Wu;Haixia Zhou;Mingzhu Xu;Shanshan Jiang;Chongsheng Qian;Shengli Xue
3 Combination of venetoclax with BCR-ABL tyrosine kinase inhibitor as a therapeutic strategy for Philadelphia chromosome-positive leukemias 期刊论文 Jing-Ying Zou;Si-Man Huang;Hai-Xia Zhoub;Ming-Zhu Xu;Ai-Ning Sun;De-Pei Wu;Sheng-Li Xue;Tong-Tong Zhang
4 二代测序检测克隆性基因突变对RUNX1-RUNX1T1阳性急性髓系白血病的预后价值 期刊论文 于景秋;薛胜利;李正;王隽;王超;储小玲;撖荣;陶涛;邱桥成;吴德沛
5 Comparing the efficacy of salvage regimens for relapsed/refractory B-cell acute lymphoblastic leukaemia: a systematic review and network meta-analysis 期刊论文 Han-Yu Cao;Chao-Ling Wan;Sheng-Li Xue
6 Ruxolitinib reduces severe CRS response by suspending CAR-T cell function instead of damaging CAR-T cells 期刊论文 Nan Xu;Xiao-Fei Yang;Sheng-Li Xue;Jing-Wen Tan;Ming-Hao Li;Jing Ye;Xiao-Yan Lou;Zhou Yu;Li-Qing Kang;Zhi-Qiang Yan;Lei Yu;Su-Ning Chen;Yi-Ting Wang
7 Phosphoproteomics profiling reveals a kinase network conferring acute myeloid leukaemia intrinsic chemoresistance and indicates HMGA1 phosphorylation as a potential influencer 期刊论文 Yinghui Zhu;Xin He;Shu Li;Yichao Gan;Zheng Li;Hanying Wang;Haojie Dong;Lei Zhang;Sheng-Li Xue;Yang Xu;Ling Li
8 Venetoclax plus hypomethylating agents in newly diagnosed acute myeloid leukemia patients with RUNX1::RUNX1T1: a retrospective propensity score matching study 期刊论文 Miao Wang;Han-Yu Cao;Kai-Wen Tan;Qiao-Cheng Qiu;Yuan-Hong Huang;Shuai-shuai Ge;Zi-Hao Wang;Jia Chen;Xiao-Wen Tang;De-Pei Wu;Sheng-Li Xue;Zheng Li;Hai-Ping Dai
9 Successful treatment of acute B lymphoblastic leukemia relapse in the skin and testicle by anti-CD19 CAR-T with IL-6 knocking down: a case report 期刊论文 Ze-Fa Liu;Li-Yun Chen;Jin Wang;Li-qing Kang;Hua Tang;Yao Zhou;Hai-Xia Zhou;Ai-Ning Sun;De-Pei Wu;Sheng-Li Xue
10 Rapid and Efficient Response to Gilteritinib and Venetoclax-Based Therapy in Two AML Patients with FLT3-ITD Mutation Unresponsive to Venetoclax Plus Azacitidine 期刊论文 Lei-Si Zhang;Jun Wang;Ming-Zhu Xu;Tian-Mei Wu;Si-Man Huang;Han-Yu Cao;Ai-Ning Sun;Song-Bai Liu;Sheng-Li Xue
11 VENETOCLAX AND AZACITIDINE COMBINED WITH CHIDAMIDE (VAC) FOR THE TREATMENT OF NEWLY DIAGNOSED ACUTE MONOCYTIC LEUKEMIA PATIENTS 会议论文 Zheng Li;Hao Zhang;Yan-Yan Li;Lu-Lu Chen;Hai-Ping Dai;Hai-Xia Zhou;Ming-Zhu Xu;Tong-Tong Zhang;Chong-Sheng Qian;Wen-Jie Gong;Qiao-Cheng Qiu;Ai-Ning Sun;De-Pei Wu;Sheng-Li Xue
12 FLT3在血液肿瘤中的作用机制及临床应用基础研究 奖励 刘松柏;薛胜利;邱桥成;鲍协炳;李正
13 FLT3 - ITD插入长度对32D细胞增殖、凋亡及靶向抑制剂敏感性的影响 期刊论文 刘松柏;董豪杰;王隽;邱桥成;薛胜利;李凌
14 造血干细胞移植患者营养状况变化与移植早期临床结局的关系 会议论文 薛胜利
15 Venetoclax Combined with Azacitidine Was Effective and Safe for Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia/ Lymphoblastic Lymphoma: Preliminary Results of a Phase 2, Multicenter Trial 会议论文 Han-Yu Cao;Lu-Lu Chen;Chao-Ling Wan;Xiao-Hui Hu;Bing Wu;Li Yang;Li Wang;Yang Zhang;De-Pei Wu;Hai-Ping Dai;Hao Zhang;Sheng-Li Xue
16 免疫治疗新技术在恶性血液病中临床转化及推广应用 奖励 吴德沛;唐晓文;徐杨;陈佳;俞磊;傅琤琤;吴小津;赵晔;刘立民;薛胜利;康立清
17 Successful application of anti-CD19 CAR-T therapy with IL-6 knocking down to patients with central nervous system B-cell acute lymphocytic leukemia 期刊论文 Chen Li-Yun;Kang Li-Qing;Zhou Hai-Xia;Gao Han-Qing;Zhu Xue-Fei;Xu Nan;Yu Lei;Wu De-Pei;Xue Sheng-Li;Sun Ai-Ning
18 Combination of Venetoclax and Midostaurin Efficiently Suppressed Relapsed t(8;21)Acute Myeloid Leukemia With Mutant KIT After Failure of Venetoclax Plus Azacitidine Treatment 期刊论文 Zheng Li;Jun Wang;Shuai-Shuai Ge;Qiao-Cheng Qiu;Jia-Hui Du;Shuang-Shuang Shan;Xiang-Dong Shen;Chao-Ling Wan;Bin-Ru Wang;De-Pei Wu;Hui-Ying Qiu;Sheng-Li Xue
19 A Combined Histone Deacetylases Targeting Strategy to Overcome Venetoclax Plus Azacitidine Regimen Resistance in Acute Myeloid Leukaemia: Three Case Reports 期刊论文 Bin-Ru Wang;Chao-Ling Wan;Song-Bai Liu;Qiao-Cheng Qiu;Tian-Mei Wu;Jun Wang;Yan-Yan Li;Shuai-Shuai Ge;Yan Qiu;Xiang-Dong Shen;Sheng-Li Xue;Zheng Li
20 The Clinical and Molecular Characteristics of FLT3 Mutations in Chinese De Novo Adolescent and Adult Acute Lymphoblastic Leukemia Patients 期刊论文 Shen Zhen;Chu Xiao-Ling;Wang Rong-Xian;Li Jin-Li;Liu Meng-Yao;Xie Yi-Yu;Wang Chao;Han Rong;Yu Jing-Qiu;Wang Jun;Tao Tao;Shen Hong-Jie;Chen Su-Ning;Wu De-Pei;Qiu Qiao-Cheng;Liu Song-Bai;Xue Sheng-Li
21 克隆性基因突变对接受强化巩固治疗的CBFβ-MYH11融合基因阳性急性髓系白血病预后的影响 期刊论文 王隽;薛胜利;李正;于景秋;王超;储小玲;撖荣;陶涛;吴天梅;王斌儒;万超玲;邱桥成;鲍协炳;吴德沛
22 Mutation spectrum of FLT3 and significance of non‐canonical FLT3 mutations in haematological malignancy 期刊论文 Shuai‐Shuai Ge;Qiao‐Cheng Qiu;Hai‐Ping Dai;Xiang‐Dong Shen;Tian‐Mei Wu;Jia‐Hui Du;Chao‐Ling Wan;Hong‐Jie Shen;De‐Pei Wu;Sheng‐Li Xue;Song‐Bai Liu
23 Flumatinib plus venetoclax as an effective therapy for Philadelphia chromosome‐positive acute myeloid leukemia: A case report 期刊论文 Si‐Man Huang;Tao Tao;Chao‐Ling Wan;Tian‐Mei Wu;Han‐Yu Cao;Yan Qiu;Xiang‐Dong Shen;Bin‐Ru Wang;Shuai‐Shuai Ge;Yan‐Yan Li;Tong‐Tong Zhang;Bing Wu;Sheng‐Li Xue
24 一种小分子化合物及其在制备治疗FLT3突变型白血病药物中的应用 专利 薛胜利;刘松柏;邱桥成;葛帅帅;王隽;杜佳慧;戴海萍
25 庇护所白血病的CART治疗 会议论文 薛胜利
26 Safety and Efficacy of CD22 and CD19 Chimeric Antigen Receptor T Cell Treatment Bridging to Autologous Stem Cell Transplantation As Consolidation Therapy for B-Cell Acute Lymphoblastic Leukemia 会议论文 Yan Qiu;Chong-Sheng Qian;Hai-Xia Zhou;Ming-Zhu Xu;Li-Qing Kang;Ai-Ning Sun;De-Pei Wu;Lei Yu;Sheng-Li Xue
27 Venetoclax combined with azacitidine as an effective and safe salvage regimen for relapsed or refractory T-cell acute lymphoblastic leukemia: a case series 期刊论文 Chao-Ling Wan;Jing-Ying Zou;Man Qiao;Jia Yin;Xiang-Dong Shen;Qiao-Cheng Qiu;Song-Bai Liu;Sheng-Li Xue
28 Targeted therapy and immunotherapy for T cell acute lymphoblastic leukemia/lymphoma 期刊论文 Yuan-hong Huang;Chao-Ling Wan;Hai-ping Dai;Sheng-li Xue
29 Anti-CD19 CAR T-Cell consolidation therapy combined with CD19+ feeding T cells and TKI for Ph+ acute lymphoblastic leukemia 期刊论文 Liyun Chen;Wen-Jie Gong;Ming-Hao Li;Hai-Xia Zhou;Ming-Zhu Xu;Chong-Sheng Qian;Li-Qing Kang;Nan Xu;Zhou Yu;Man Qiao;Tong-Tong Zhang;Ling Zhang;Zheng-Long Tian;Ai-Ning Sun;Lei Yu;De-Pei Wu;Sheng-Li Xue
30 Small molecule compound and its application in preparing medicine for treating FLT3 mutant leukemia 专利 Shengli Xue;Songbai Liu;Shuaishuai Ge;Jiahui Du;Qiaocheng Qiu;Haiping Dai;Jun Wang
31 Abnormal body composition related to the early clinical adverse outcome after HSCT 期刊论文 Li-Ling Zong;Xiang Zhang;Shan-Shan Jiang;Bo Hu;Yong-Qin Ge;Xia-Ming Zhu;Shengli Xue;Jing Yang
32 KIT及其他克隆性基因突变对核心结合因子相关急性髓系白血病的预后价值 期刊论文 吴天梅;薛胜利;李正;于景秋;王隽;王斌儒;万超玲;申向东;邱桥成;鲍协炳;吴德沛
33 BCR∷ABL1 和CBFB∷MYH11 融合基因双表达的髓系白血病3例报道并文献复习 期刊论文 王梦淼;黄斯漫;万超玲;吴天梅;李岩岩;曹涵钰;申向东;邱艳;葛帅帅;周海侠;李正;孙爱宁;薛胜利
34 Chidamide: Targeting epigenetic regulation in the treatment of hematological malignancy 期刊论文 Han‐Yu Cao;Ling Li;Sheng‐Li Xue;Hai‐Ping Dai
35 Efficiency of anti‐VEGF therapy in central nervous system AML relapse: A case report and literature review 期刊论文 Han-Yu Cao;Tao Tao;Xiang-Dong Shen;Lian Bai;Chao-Ling Wan;De-Pei Wu;Jin-Li Li;Sheng-Li Xue
36 A Phase II Trial of the Double Epigenetic Priming Regimen Including Chidamide and Decitabine for Relapsed/Refractory Acute Myeloid Leukemia 期刊论文 Jia Yin;Chao-Ling Wan;Ling Zhang;Hao Zhang;Lian Bai;Hai-Xia Zhou;Ming-Zhu Xu;Li-Yun Chen;Chong-Sheng Qian;Hui-Ying Qiu;Su-Ning Chen;Xiao-Wen Tang;De-Pei Wu;Yan-Ming Zhang;Ai-Ning Sun;Sheng-Li Xue
37 Epigenetic therapy with chidamide alone or combined with 5‑azacitidine exerts antitumour effects on acute myeloid leukaemia cells invitro 期刊论文 Zheng Li;Jian Zhang;Min Zhou;Jin-Li Li;Qiao-Cheng Qiu;Jian-Hong Fu;Sheng-Li Xue;Hui-Ying Qiu
38 Mutation Spectrum of FLT3 and Significance of Non-Canonical FLT3 Mutations in Hematological Malignancies 会议论文 Shuai-Shuai Ge;Xiang-Dong Shen;Tian-Mei Wu;Jia-Hui Du;Hai-Ping Dai;Qiao-Cheng Qiu;Song-Bai Liu;De-Pei Wu;Sheng-Li Xue
39 Venetoclax, Cladribine and Cytarabine for the Treatment of Relapse/Refractory Acute Lymphoblastic Leukemia: Interim Analysis of a Phase 2 Trial 会议论文 Yan-Yan Li;Hai-Xia Zhou;Si-man Huang;Chao-Ling Wan;Ming-Zhu Xu;Wen-Jie Gong;Chong-Sheng Qian;De-Pei Wu;Hai-Ping Dai;Sheng-Li Xue
40 Venetoclax, Cladribine Plus Low-Dose Cytarabine Achieved High Remission in Patients with Relapse/Refractory Acute Leukemia: Preliminary Results of a Phase II Study 会议论文 Yan-Yan Li;Hai-Xia Zhou;Chao-Ling Wan;Ming-Zhu Xu;Chong-Sheng Qian;Tong-Tong Zhang;Hai-Ping Dai;Ai-Ning Sun;De-Pei Wu;Sheng-Li Xue
41 西达本胺、地西他滨双表观联合预激方案治疗复发难治急性髓细胞白血病 会议论文 薛胜利
42 The differential effects of tumor burdens on predicting the net benefits of ssCART-19 cell treatment on r/r B-ALL patients 期刊论文 Minghao Li;Sheng-Li Xue;Xiaowen Tang;Jiayu Xu;Suning Chen;Yue Han;Huiying Qiu;Miao Miao;Nan Xu;Jingwen Tan;Liqing Kang;Zhou Yu;Xiaoyan Lou;Yang Xu;Jia Chen;Zhiqiang Yan;Weixing Feng;Depei Wu;Lei Yu
43 Developments and challenges of FLT3 inhibitors in acute myeloid leukemia 期刊论文 Shuai-Shuai Ge;Song-Bai Liu;Sheng-Li Xue
44 Safety and Efficacy of CD22/ CD19 CAR-T and Auto-HSCT “Sandwich” Strategy As Consolidation Therapy for Ph Negative B Cell Acute Lymphoblastic Leukemia 会议论文 Yan Qiu;Chong-Sheng Qian;Hai-Xia Zhou;Ming-Zhu Xu;Li-Qing Kang;Ai-Ning Sun;De-Pei Wu;Lei Yu;Sheng-Li Xue
45 RUNX1 Mutation Does Not Significantly Impact the Outcome of Newly Diagnosed adult AML: A Retrospective Study of Chinese AML Patients 会议论文 Chao-Ling Wan;Yuan-Hong Huang;Si-Man Huang;Tong-Tong Zhang;Kai-Wen Tan;Yan Qiu;Xiang-Dong Shen;Shuai-Shuai Ge;Han-Yu Cao;Yan-Yan Li;Song-Bai Liu;Qiao-Cheng Qiu;Hai-Ping Dai;Sheng-Li Xue
46 Investigation of the risk factors to predict cytokine release syndrome in relapsed or refractory B-cell acute lymphoblastic leukemia patients receiving IL-6 knocking down anti-CD19 chimeric antigen receptor T-cell therapy 期刊论文 Wen-Jie Gong;Yan Qiu;Ming-Hao Li;Li-Yun Chen;Yan-Yan Li;Jing-Qiu Yu;Li-Qing Kang;Ai-Ning Sun;De-Pei Wu;Lei Yu;Sheng-Li Xue
47 Rapid molecular response to dasatinib in Ph-like acute lymphoblastic leukemia patients with ABL1 rearrangements: case series and literature review 期刊论文 Kai-Wen Tan;Yi-Yan Zhu;Qiao-Cheng Qiu;Man Wang;Hong-Jie Shen;Si-Man Huang;Han-Yu Cao;Chao-Ling Wan;Yan-Yan Li;Hai-Ping Dai;Sheng-Li Xue
48 Safety and efficacy of CD22 and CD19 CAR-T bridging auto-HSCT as consolidation therapy for AYA and adult B-ALL 期刊论文 Yan Qiu;Chao-Ling Wan;Ming-Zhu Xu;Hai-Xia Zhou;Mei-Jing Liu;Wen-Jie Gong;Li-Qing Kang;Ai-Ning Sun;Lei Yu;De-Pei Wu;Chong-Sheng Qian;Sheng-Li Xue
49 Case Report: Blinatumomab therapy for the treatment of B-cell acute lymphoblastic leukemia patients with central nervous system infiltration 期刊论文 Han-Yu Cao;Hui Chen;Song-Bai Liu;Wen-Jie Gong;Chong-Sheng Qian;Tong-Tong Zhang;Chao-Ling Wan;Si-Man Huang;Nan Xu;Hai-Ping Dai;Sheng-Li Xue
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