原料晶型对药物共晶机械化学合成产物调变的固体核磁共振研究

21874148
2018
B0403.谱学方法与理论
张海禄
面上项目
研究员
中国科学院苏州纳米技术与纳米仿生研究所
64万元
药物共晶;机械化学合成;多晶型;固体核磁共振
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Cocrystals of Natural Products: Improving the Dissolution Performance of Flavonoids Using Betaine 期刊论文 Zhijie Zhang;Duanxiu Li;Chun Luo;Chunxiang Huang;Ruchen Qiu;Zongwu Deng;Hailu Zhang
2 Stanozolol-aromatic carboxylic acid crystalline complexes: Flexible tautomeric/ionization states and supramolecular synthons 期刊论文 Wang Xiaojuan;Kong Minmin;Li Duanxiu;Fang Jianhui;Deng Zongwu;Zhang Hailu
3 Crystal structures, dissolution and pharmacokinetic study on a novel phosphodiesterase-4 inhibitor chlorbipram cocrystals 期刊论文 Zhou Jianle;Li Liang;Zhang Hailu;Xu Jiangping;Huang Dandan;Gong Ningbo;Han Weili;Yang Xuemei;Zhou Zhengzheng
4 Similarity and Diversity: Cocrystallization of Baricitinib with Four C4-Dicarboxylic Acids 期刊论文 Wang Xiaojuan;Xie Qihuang;Gao Di;Ye Xin;Deng Zongwu;Zhang Hailu
5 Structural features of sulfamethizole and its cocrystals: Beauty within 期刊论文 Yuan Yue;Li Duanxiu;Wang Chenguang;Chen Shaodong;Kong Minmin;Deng Zongwu;Sun Changquan Calvin;Zhang Hailu
6 磺胺甲噻二唑-糖精共晶及其制备方法与应用 专利 张海禄;袁月;邓宗武
7 Venlafaxine Caffeic Acid Salt: Synthesis, Structural Characterization, and Hypoglycemic Effect Analysis 期刊论文 Yu Hongmei;Zhang Yong;Xing Cheng;Wang Ying;Zhang Hailu;Gong Ningbo;Lu Yang;Du Guanhua
8 Co-amorphous systems of sinomenine with nonsteroidal anti-inflammatory drugs: A strategy for solubility improvement, sustained release, and drug combination therapy against rheumatoid arthritis 期刊论文 Chen Xin;Li Duanxiu;Zhang Hailu;Duan Yanwen;Huang Yong
9 Structure determination and in vitro/vivo study on carbamazepine-naringenin (1:1) cocrystal 期刊论文 Zhou Feiyuan;Zhou Jianle;Zhang Hailu;Tong Henry H.Y.;Nie Jinju;Li Liang;Zhang Yingyi;Du Juan;Ma Ande;Yang Xuemei;Zhou Zhengzheng
10 Ketoconazole: Solving the poor solubility via cocrystal formation with phenolic acids 期刊论文 Chen Xin;Li Duanxiu;Deng Zongwu;Zhang Hailu
11 Salt or/and cocrystal? The case of the antidepressant drug venlafaxine 期刊论文 Yu Hongmei;Zhang Yong;Zhang Baoxi;Wang Ying;Zhang Li;Zhang Hailu;Gong Ningbo;Lu Yang;Du Guanhua
12 Platensimycin-berberine chloride co-amorphous drug system: Sustained release and prolonged half-life 期刊论文 Wang Zhe;Chen Xin;Li Duanxiu;Bai Enhe;Zhang Hailu;Yanwen Duan;Huang Yong
13 Drug-drug cocrystals of theophylline with quercetin 期刊论文 Wang Lin;Li Shuyan;Xu Xiaozhou;Xu Xiaoyan;Wang Qing;Li Duanxiu;Zhang Hailu
14 一种5-氟尿嘧啶与肌氨酸的共晶体及其制备方法与用途 专利 谢起煌;张海禄;万文;王晓娟;叶馨
15 Co-amorphous Systems of Sinomenine with Platensimycin or Sulfasalazine: Physical Stability and Excipient-Adjusted Release Behavior 期刊论文 Chen Xin;Li Duanxiu;Zhang Hailu;Duan Yanwen;Huang Yong
16 Determination of tautomeric preference of fenobam in solution by high‐resolution NMR spectroscopy 期刊论文 Sha Xuming;Chen Shaodong;Zheng Xiaojing;Ye Xin;Zhang Hailu;Huang Shaohua
17 Sinomenine-phenolic acid coamorphous drug systems: Solubilization, sustained release, and improved physical stability 期刊论文 Chen Xin;Li Duanxiu;Zhang Hailu;Duan Yanwen;Huang Yong
18 The discovery of new cocrystals of 5-fluorocytosine using amine–carboxylate supramolecular synthon 期刊论文 Li Duanxiu;Li Jiong;Deng Zongwu;Zhang Hailu
19 晶型药物 专著 吕扬;吕丽娟;邢逞;杜立达;杜冠华;杨世颖;杨德智;应剑;宋俊科;张羽男;张丽;张海禄;陈嘉媚;周政政;胡秀荣;郭放;龚宁波;鲁统部;强桂芬;蔡挺
20 Collecting the Molecular and Ionization States of Irbesartan in the Solid State 期刊论文 Wang Xiaojuan;Gao Di;Li Duanxiu;Xie Qihuang;Deng Zongwu;Zhang Hailu
21 Phase solubility diagrams and energy surface calculations support the solubility enhancement with low hygroscopicity of Bergenin: 4-Aminobenzamide (1: 1) cocrystal 期刊论文 Liu Hongji;Nie Jinju;Chan H. C. Stephen;Zhang Hailu;Li Liang;Lin Hongqing;Tong Henry H.Y.;Ma Ande;Zhou Zhengzheng
22 How Many Parameters Can Affect the Solid Form of Cocrystallization Products in Mechanochemical Reactions? A Case Study 期刊论文 Yuan Yue;Wang Lin;Li Duanxiu;Deng Zongwu;Zhang Hailu
23 一种厄贝沙坦哌嗪盐及其制备方法和应用 专利 张海禄;邓宗武;王晓娟
24 氟胞嘧啶-L-苯丙氨酸共晶及其制备方法和应用 专利 李端秀;张海禄;邓宗武
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