靶向抑制PAK4-KIF20A-GATA4分子轴重启AML细胞衰老的作用和机制研究
81770145
2017
H0809.白血病
潘健
面上项目
研究员
苏州大学
55万元
KIF20A;PAK4;GATA4;急性髓细胞白血病;肿瘤细胞衰老
2018-01-01到2021-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | 一种人鼠嵌合单克隆抗体及其制备方法和应用 | 专利 | 倪健;梁辉;潘健;陈建鹤;廖新梅 |
| 2 | 长链非编码RNA AC002454.1对NB4细胞生物学功能的影响 | 期刊论文 | 曹岚;胡绍燕;潘健;王易;何海龙;卢俊;肖佩芳;杜智卓;古桂雄;柴忆欢 |
| 3 | 儿童急性髓细胞白血病表观遗传关键靶点的转化应用研究 | 奖励 | 胡绍燕;王前飞;陶燕芳;卢俊;肖佩芳;胡昳歆;何海龙;王易;李建琴;孙伊娜;凌婧 |
| 4 | ARV-825 Demonstrates Antitumor Activity in Gastric Cancer via MYC-Targets and G2M-Checkpoint Signaling Pathways. | 期刊论文 | Liao Xinmei;Qian Xiaoqing;Zhang Zimu;Tao Yanfang;Li Zhiheng;Zhang Qian;Liang Hui;Li Xiaolu;Xie Yi;Zhuo Ran;Chen Yanling;Jiang You;Cao Haibo;Niu Jiaqi;Xue Cuili;Ni Jian;Pan Jian;Cui Daxiang |
| 5 | MI-773, a breaker of the MDM2/p53 axis, exhibits anticancer effects in neuroblastoma via downregulation of INSM1. | 期刊论文 | Chen Yan-Ling;Zhang Zi-Mu;Li Xiao-Lu;Tao Yan-Fang;Wu Shui-Yan;Fang Fang;Xie Yi;Liao Xin-Mei;Li Gen;Wu Di;Wang Hai-Rong;Zuo Ran;Cao Hai-Bo;Pan Jing-Jing;Yu Juan-Juan;Zhang Zheng;Chu Xin-Ran;Zhang Yong-Ping;Feng Chen-Xi;Wang Jian-Wei;Lu Jun;Hu Shao-Yan;Li Zhi-Heng;Pan Jian |
| 6 | The dual role of BI 2536, a small-molecule inhibitor that targets PLK1, in induction of apoptosis and attenuation of autophagy in neuroblastoma cells. | 期刊论文 | Li Zhiheng;Yang Chun;Li Xiaolu;Du Xiaojuan;Tao Yanfang;Ren Junli;Fang Fang;Xie Yi;Li Mei;Qian Guanghui;Xu Lixiao;Cao Xu;Wu Yi;Lv Haitao;Hu Shaoyan;Lu Jun;Pan Jian |
| 7 | PROTAC Bromodomain Inhibitor ARV-825 Displays Anti-Tumor Activity in Neuroblastoma by Repressing Expression of MYCN or c-Myc. | 期刊论文 | Li Zhiheng;Lim Su Lin;Tao Yanfang;Li Xiaolu;Xie Yi;Yang Chun;Zhang Zimu;Jiang You;Zhang Xianbing;Cao Xu;Wang Hairong;Qian Guanghui;Wu Yi;Li Mei;Fang Fang;Liu Ying;Fu Mingcui;Ding Xin;Zhu Zhenghong;Lv Haitao;Lu Jun;Xiao Sheng;Hu Shaoyan;Pan Jian |
| 8 | BRD4 PROTAC degrader ARV-825 inhibits T-cell acute lymphoblastic leukemia by targeting 'Undruggable' Myc-pathway genes | 期刊论文 | Wu Shuiyan;Jiang You;Hong Yi;Chu Xinran;Zhang Zimu;Tao Yanfang;Fan Ziwei;Bai Zhenjiang;Li Xiaolu;Chen Yanling;Li Zhiheng;Ding Xin;Lv Haitao;Du Xiaoli;Lim Su Lin;Zhang Yongping;Huang Saihu;Lu Jun;Pan Jian;Hu Shaoyan |
| 9 | Lineage-Specific Epigenomic and Genomic Activation of Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas. | 期刊论文 | Pan Jian;Silva Tiago C;Gull Nicole;Yang Qian;Plummer Jasmine T;Chen Stephanie;Daigo Kenji;Hamakubo Takao;Gery Sigal;Ding Ling-Wen;Jiang Yan-Yi;Hu Shaoyan;Xu Li-Yan;Li En-Min;Ding Yanbing;Klempner Samuel J;Gayther Simon A;Berman Benjamin P;Koeffler H Phillip;Lin De-Chen |
| 10 | CCL2通过白血病细胞THP-1自分泌多种炎性趋化因子调控其迁移和侵袭 | 期刊论文 | 洪丹;颜青;杨进;潘健;岑建农;陈苏宁;胡绍燕 |
| 11 | Proteomic profiling and bioinformatics analysis identify key regulators during the process from fanconi anemia to acute myeloid leukemia | 期刊论文 | Hou Hui;Li Dan;Gao Junyan;Gao Li;Lu Qin;Hu Yixin;Wu Shuiyan;Chu Xinran;Yao Yanhua;Wan Lin;Ling Jing;Pan Jian;Xu Guoqiang;Hu Shaoyan |
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