线粒体calpain-1调控活性氧产生在糖尿病心肌病发生中的作用

81470499
2014
H0207.心肌炎和心肌病
彭天庆
面上项目
教授
苏州大学
68万元
钙调节蛋白酶;线粒体;糖尿病心肌病;ATP合成酶;活性氧
2015-01-01到2018-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice. 期刊论文 Zheng Dong;Ma Jian;Yu Yong;Li Minghui;Ni Rui;Wang Grace;Chen Ruizhen;Li Jianmin;Fan Guo-Chang;Lacefield James C;Peng Tianqing
2 Increased calpain-1 in cardiomyocyte mitochondria disrupts ATP synthase and promotes reactive oxygen species generation to induce dilated heart failure in mice. 会议论文 彭天庆
3 Inhibition of MicroRNA 195 Prevents Apoptosis and Multiple-Organ Injury in Mouse Models of Sepsis. 期刊论文 Zheng Dong;Yu Yong;Li Minghui;Wang Grace;Chen Ruizhen;Fan Guo-Chang;Martin Claudio;Xiong Sidong;Peng Tianqing
4 Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy. 期刊论文 Ni Rui;Zheng Dong;Xiong Sidong;Hill David J;Sun Tao;Gardiner Richard B;Fan Guo-Chang;Lu Yanrong;Abel E Dale;Greer Peter A;Peng Tianqing
5 Therapeutic inhibition of mitochondrial reactive oxygen species with mito-TEMPO reduces diabetic cardiomyopathy. 期刊论文 Ni Rui;Cao Ting;Xiong Sidong;Ma Jian;Fan Guo-Chang;Lacefield James C;Lu Yanrong;Tissier Sydney Le;Peng Tianqing
6 Calpain-1 induces endoplasmic reticulum stress in promoting cardiomyocyte apoptosis following hypoxia/reoxygenation. 期刊论文 Zheng Dong;Wang Grace;Li Shuai;Fan Guo-Chang;Peng Tianqing
7 Disruption of calpain reduces lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress. 期刊论文 Shengcun Li;Lulu Zhang;Rui Ni;Ting Cao;Dong Zheng;Sidong Xiong;Peter A Greer;Guo-Chang Fan;Tianqing Peng
8 Deletion of capn4 Protects the Heart Against Endotoxemic Injury by Preventing ATP Synthase Disruption and Inhibiting Mitochondrial Superoxide Generation. 期刊论文 Ni Rui;Zheng Dong;Wang Qiang;Yu Yong;Chen Ruizhen;Sun Tao;Wang Wang;Fan Guo-Chang;Greer Peter A;Gardiner Richard B;Peng Tianqing
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