肿瘤靶向和双硫交联的多功能高分子纳米药物

51633005
2016
E0308.生物医用有机高分子材料
钟志远
重点项目
教授
苏州大学
295万元
纳米药物;药物释放;还原敏感;肿瘤靶向;生物可降解高分子
2017-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 交叉学科全球高被引科学家 2020 奖励 钟志远
2 Coating-Sheddable CD44-Targeted PLGA Nanomedicines Fabricated Using Photo-Click-Crosslinkable Hyaluronic Acid-graft-Tetrazole Conjugate as a Surfactant 期刊论文 Shuai Li;Min Qiu;Jiakun Guo;Xiaofei Zhao;Zhiyuan Zhong;Chao Deng
3 Targeted inhibition of human hematological cancers in vivo by doxorubicin encapsulated in smart lipoic acid-crosslinked hyaluronic acid nanoparticles 期刊论文 Zhong Yinan;Meng Fenghua;Deng Chao;Mao Xinliang;Zhong Zhiyuan
4 alpha(v)beta(3) integrin-targeted micellar mertansine prodrug effectively inhibits triple-negative breast cancer in vivo 期刊论文 Zhong Ping;Gu Xiaolei;Cheng Ru;Deng Chao;Meng Fenghua;Zhong Zhiyuan
5 Adaptive Polymersome and Micelle Morphologies in Anticancer Nanomedicine: From Design Rationale to Fabrication and Proof-of-Concept Studies 期刊论文 Imke A B Pijpers;Loai K E A Abdelmohsen;Yifeng Xia;Shoupeng Cao;David S Williams;Fenghua Meng;Jan C M van Hest;Zhiyuan Zhong
6 具有不对称膜结构的可逆交联聚合物囊泡、抗肿瘤药物及其制备方法 专利 孟凤华;邹艳;杨炜静;孟浩;钟志远
7 Dual-targeted nanomedicines for enhanced tumor treatment 期刊论文 Zhu Yaqin;Jan Feijen;Zhong Zhiyuan
8 抗肿瘤药物及其制备方法 专利 孟凤华;方媛;杨炜静;邹艳;钟志远
9 生物可降解双亲性聚合物、由其制备的聚合物囊泡及在制备肺癌靶向治疗药物中的应用 专利 孟凤华;邹艳;方媛;钟志远
10 Cancer Nanomedicines Based on Synthetic Polypeptides 期刊论文 Sun Huanli;Gu Xiaolei;Zhang Qiang;Xu Hao;Zhong Zhiyuan;Deng Chao
11 聚乙二醇-b-聚酪氨酸-硫辛酸共聚物、聚多肽胶束及其制备方法与应用 专利 邓超;薛松;顾晓雷;钟志远
12 内膜具有正电的可逆交联生物可降解聚合物囊泡及其制备方法与在制备抗肿瘤药物中的应用 专利 孟凤华;方媛;杨炜静;邹艳;钟志远
13 具有不对称膜结构的可逆交联生物可降解聚合物囊泡及其制备方法 专利 孟凤华;邹艳;杨炜静;孟浩;钟志远
14 内膜具有正电的可逆交联生物可降解聚合物囊泡及其制备方法与在制备抗肿瘤药物中的应用 专利 孟凤华;方媛;杨炜静;邹艳;钟志远
15 一种抗肿瘤药物的制备方法 专利 邓超;陈景;孟凤华;钟志远
16 Doxorubicin Delivered via ApoE-Directed Reduction-Sensitive Polymersomes Potently Inhibit Orthotopic Human Glioblastoma Xenografts in Nude Mice. 期刊论文 Ouyang Jia;Jiang Yu;Deng Chao;Zhong Zhiyuan;Lan Qing
17 基于聚氨基酸的功能性生物可降解纳米粒子的制备方法 专利 邓超;武金田;孟凤华;钟志远
18 Small, Traceable, Endosome-Disrupting, and Bioresponsive Click Nanogels Fabricated via Microfluidics for CD44-Targeted Cytoplasmic Delivery of Therapeutic Proteins 期刊论文 Huang Ke;He Yahui;Zhu Zhehong;Guo Jiakun;Wang Guanglin;Deng Chao;Zhong Zhiyuan
19 Nanoagents Based on Poly(ethylene glycol)-b-Poly(l-thyroxine) Block Copolypeptide for Enhanced Dual-Modality Imaging and Targeted Tumor Radiotherapy 期刊论文 Gu Xiaolei;Zhu Zhehong;Fan Qianyi;Wei Yaohua;Wang Guanglin;Meng Fenghua;Zhong Zhiyuan;Deng Chao
20 pH-Sensitive Coiled-Coil Peptide-Cross-Linked Hyaluronic Acid Nanogels: Synthesis and Targeted Intracellular Protein Delivery to CD44 Positive Cancer Cells 期刊论文 Ding Lingling;Jiang Yu;Zhang Jian;Klok Harm Anton;Zhong Zhiyuan
21 Lipoyl Ester Terminated Star PLGA as a Simple and Smart Material for Controlled Drug Delivery Application 期刊论文 Wang Xiuxiu;Cheng Ru;Cheng Liang;Zhong Zhiyuan
22 具有不对称膜结构的可逆交联生物可降解聚合物囊泡及其制备方法与在核酸药物中的应用 专利 孟凤华;邹艳;杨炜静;孟浩;钟志远
23 囊泡纳米药物在制备脑肿瘤治疗药物中的应用 专利 钟志远;张建;姜宇;孟凤华
24 基于2-氨基十六烷酸的N-羧基内酸酐单体和聚氨基酸及其制备方法 专利 邓超;邱敏;钟志远
25 基于透明质酸的两亲聚合物、其制备方法与应用 专利 钟志远;钟伊南 孟凤华
26 Highly efficacious and specific anti-glioma chemotherapy by tandem nanomicelles co-functionalized with brain tumor-targeting and cell-penetrating peptides 期刊论文 Zhu Yaqin;Yu Jiang;Meng Fenghua;Chao Deng;Ru Cheng;Jian Zhang;Jan Feijen;Zhong Zhiyuan
27 Hyaluronic acid shell and disulfide-crosslinked core micelles for in vivo targeted delivery of bortezomib for the treatment of multiple myeloma 期刊论文 Gu Zhaoxin;Wang Xiuxiu;Cheng Ru;Cheng Liang;Zhong Zhiyuan
28 囊泡纳米药物在制备脑肿瘤治疗药物中的应用 专利 张建;钟志远;姜宇;史亚南;孟凤华
29 Lipopepsomes: A novel and robust family of nano-vesicles capable of highly efficient encapsulation and tumor-targeted delivery of doxorubicin hydrochloride in vivo 期刊论文 Qiu Min;Sun Huanli;Meng Fenghua;Cheng Ru;Zhang Jian;Deng Chao;Zhong Zhiyuan
30 Dually Active Targeting Nanomedicines Based on a Direct Conjugate of Two Purely Natural Ligands for Potent Chemotherapy of Ovarian Tumors 期刊论文 Yan Yu;Dong Yangyang;Yue Shujing;Qiu Xinyun;Sun Huanli;Zhong Zhiyuan
31 Cetuximab-Polymersome-Mertansine Nanodrug for Potent and Targeted Therapy of EGFR-Positive Cancers. 期刊论文 Yue Shujing;Zhang Yifan;Wei Yaohua;Haag Rainer;Sun Huanli;Zhong Zhiyuan
32 An intelligent cell-selective polymersome-DM1 nanotoxin toward triple negative breast cancer. 期刊论文 Zhang Yifan;Yue Shujing;Haag Rainer;Sun Huanli;Zhong Zhiyuan
33 Enzyme-responsive micellar JQ1 induces enhanced BET protein inhibition and immunotherapy of malignant tumors. 期刊论文 Zhang Zhenqi;Zhang Qiang;Xie Jiguo;Zhong Zhiyuan;Deng Chao
34 基于末端含硫辛酰基星型聚合物的纳米药物 专利 程茹;王秀秀;钟志远
35 侧链含硫辛酰基的聚合物、其制备方法及由其制备的聚合物囊泡及其应用 专利 孟凤华;杨炜静;钟志远
36 一种侧链含双碘功能基团的生物可降解聚合物及其应用 专利 钟志远;邹艳;孟凤华
37 Reduction-responsive core-crosslinked hyaluronic acid-b-poly(trimethylene carbonate-co-dithiolane trimethylene carbonate) micelles: synthesis and CD44-mediated potent delivery of docetaxel to triple negative breast tumor in vivo 期刊论文 Zhu Yaqin;Zhang Jian;Meng Fenghua;Cheng Liang;Feijen Jan;Zhong Zhiyuan
38 cRGD-installed docetaxel-loaded mertansine prodrug micelles: redox-triggered ratiometric dual drug release and targeted synergistic treatment of B16F10 melanoma 期刊论文 Zhong Ping;Qiu Min;Zhang Jian;Sun Huanli;Cheng Ru;Deng Chao;Meng Fenghua;Zhong Zhiyuan
39 HER2-Specific Reduction-Sensitive Immunopolymersomes with High Loading of Epirubicin for Targeted Treatment of Ovarian Tumor 期刊论文 Ding Lin;Gu Wenxing;Zhang Yifan;Yue Shujing;Sun Huanli;Cornelissen Jeroen J L M;Zhong Zhiyuan
40 Polymeric nanomedicines targeting hematological malignancies. 期刊论文 Gu Wenxing;Qu Ruobing;Meng Fenghua;Cornelissen Jeroen J L M;Zhong Zhiyuan
41 聚合物囊泡在制备治疗多发性骨髓瘤药物中的应用 专利 钟志远;钟伊南;孟凤华
42 交叉学科全球高被引科学家 2019 奖励 钟志远
43 侧链含双硫五元环功能基团的碳酸酯聚合物的应用 专利 孟凤华;邹艳;钟志远
44 Glutathione-Sensitive Hyaluronic Acid-Mercaptopurine Prodrug Linked via Carbonyl Vinyl Sulfide: A Robust and CD44-Targeted Nanomedicine for Leukemia 期刊论文 Qiu Jie;Cheng Ru;Zhang Jian;Sun Huanli;Deng Chao;Meng Fenghua;Zhong Zhiyuan
45 EGFR and CD44 Dual-Targeted Multifunctional Hyaluronic Acid Nanogels Boost Protein Delivery to Ovarian and Breast Cancers In Vitro and In Vivo 期刊论文 Chen Jing;Ouyang Jia;Chen Qijun;Deng Chao;Meng Fenghua;Zhang Jian;Cheng Ru;Lang Qing;Zhong Zhiyuan
46 Daratumumab Immunopolymersome-Enabled Safe and CD38-Targeted Chemotherapy and Depletion of Multiple Myeloma. 期刊论文 Yu Na;Zhang Yifan;Li Jiaying;Gu Wenxing;Yue Shujing;Li Bin;Meng Fenghua;Sun Huanli;Haag Rainer;Yuan Jiandong;Zhong Zhiyuan
47 美国医学与生物工程院会士(AIMBE Fellow) 奖励 钟志远
48 药理学/毒理学领域 全球高被引科学家 2018 奖励 钟志远
49 Polytyrosine nanoparticles enable ultra-high loading of doxorubicin and rapid enzyme-responsive drug release 期刊论文 Gu Xiaolei;Qiu Min;Sun Huanli;Zhang Jian;Cheng Liang;Deng Chao;Zhong Zhiyuan
50 Hyaluronic Acid-Shelled Disulfide-Cross-Linked Nanopolymersomes for Ultrahigh-Efficiency Reactive Encapsulation and CD44-Targeted Delivery of Mertansine Toxin 期刊论文 Zhang Yue;Wu Kaiqi;Sun Huanli;Zhang Jian;Yuan Jiandong;Zhong Zhiyuan
51 Selective transferrin coating as a facile strategy to fabricate BBB-permeable and targeted vesicles for potent RNAi therapy of brain metastatic breast cancer in vivo. 期刊论文 Wei Yaohua;Sun Yinping;Wei Jingjing;Qiu Xinyun;Meng Fenghua;Storm Gert;Zhong Zhiyuan
52 Peptide-decorated polymeric nanomedicines for precision cancer therapy 期刊论文 Huanli Sun;Yangyang Dong;Jan Feijen;Zhiyuan Zhong
53 还原敏感可逆交联的具有不对称膜结构的聚合物囊泡及其在制备治疗肝癌药物中的应用 专利 孟凤华;钟志远;周程;魏晶晶;魏耀华;夏一枫
54 Biodegradable Micelles Based on Poly(ethylene glycol)-b-polylipopeptide Copolymer: A Robust and Versatile Nanoplatform for Anticancer Drug Delivery 期刊论文 Qiu Min;Ouyang Jia;Sun Huanli;Meng Fenghua;Cheng Ru;Zhang Jian;Cheng Liang;Lan Qing;Deng Chao;Zhong Zhiyuan
55 Exogenous vitamin C boosts the antitumor efficacy of paclitaxel containing reduction-sensitive shell-sheddable micelles in vivo 期刊论文 Zhu Yaqin;Wang Xiuxiu;Zhang Jian;Meng Fenghua;Deng Chao;Cheng Ru;Jan Feijen;Zhong Zhiyuan
56 Polymers from Nature and for Nature 期刊论文 Sun Huanli;Klok Harm Anton;Zhong Zhiyuan
57 α(v)β(3) Integrin-targeted reduction-sensitive micellar mertansine prodrug: Superb drug loading, enhanced stability, and effective inhibition of melanoma growth in vivo. 期刊论文 Zhong Ping;Meng Hao;Qiu Jie;Zhang Jian;Sun Huanli;Cheng Ru;Zhong Zhiyuan
58 一种侧链含双硫五元环功能基团的碳酸酯聚合物在制备药物控制释放载体中的应用 专利 孟凤华;邹艳;钟志远
59 可逆交联不对称囊泡在制备治疗急性白血病药物中的应用 专利 孟凤华;钟伊南;钟志远
60 基于主动反应型一步法的交联纳米药物的制备方法 专利 钟志远;孟凤华;孟浩;张玥
61 透明质酸-g-叶酸聚合物及其应用 专利 孙欢利;鄢雨;钟志远
62 Tailor-Making Fluorescent Hyaluronic Acid Microgels via Combining Microfluidics and Photoclick Chemistry for Sustained and Localized Delivery of Herceptin in Tumors 期刊论文 Chen Jing;Huang Ke;Chen Qijun;Deng Chao;Zhang Jian;Zhong Zhiyuan
63 Cyclic carbonate monomer containing double iodine, biodegradable polymer prepared thereby and use 专利 钟志远;邹艳;魏耀华;孟凤华
64 Targeted and Reduction-Sensitive Cross-Linked PLGA Nanotherapeutics for Safer and Enhanced Chemotherapy of Malignant Melanoma 期刊论文 Wang Xiuxiu;Qu Min;Deng Chao;Cheng Ru;Zhong Zhiyuan
65 药理学/毒理学领域 全球高被引科学家 2021 奖励 钟志远
66 A6 Peptide-Tagged Core-Disulfide-Cross-Linked Micelles for Targeted Delivery of Proteasome Inhibitor Carfilzomib to Multiple Myeloma In Vivo 期刊论文 Changjiang Zhang;Xiuxiu Wang;Ru Cheng;Zhiyuan Zhong
67 Micellar nanoformulation of lipophilized bortezomib: high drug loading, improved tolerability and targeted treatment of triple negative breast cancer 期刊论文 Wu Kaiqi;Cheng Ru;Zhang Jian;Meng Fenghua;Deng Chao;Zhong Zhiyuan
68 Saporin-loaded CD44 and EGFR dual-targeted nanogels for potent inhibition of metastatic breast cancer in vivo 期刊论文 Chen Jing;He Hua;Deng Chao;Yin Lichen;Zhong Zhiyuan
69 Smart Polymersomes Dually Functionalized with cRGD and Fusogenic GALA Peptides Enable Specific and High-Efficiency Cytosolic Delivery of Apoptotic Proteins 期刊论文 Yao Peili;Zhang Yifan;Meng Hao;Sun Huanli;Zhong Zhiyuan
70 末端含硫辛酰基的星型聚合物的制备方法及聚合物纳米粒子的制备方法, 专利 程茹;王秀秀;钟志远
71 生物可降解交联纳米药物冻干粉的制备方法 专利 孟凤华;钟志远;孟浩;李泽坤
72 Facile fabrication of robust, hyaluronic acid-surfaced and disulfide-crosslinked PLGA nanoparticles for tumor-targeted and reduction-triggered release of docetaxel. 期刊论文 Wang Xiuxiu;Cheng Ru;Zhong Zhiyuan
73 cRGD/TAT Dual-Ligand Reversibly Cross-Linked Micelles Loaded with Docetaxel Penetrate Deeply into Tumor Tissue and Show High Antitumor Efficacy in Vivo 期刊论文 Zhu Yaqin;Jian Zhang;Meng Fenghua;Chao Deng;Ru Cheng;Feijen Jan;Zhong Zhiyuan
74 CD38-Directed Vincristine Nanotherapy for Acute Lymphoblastic Leukemia. 期刊论文 Zhang Yifan;An Jingnan;Shao Yu;Yu Na;Yue Shujing;Sun Huanli;Zhang Jubin;Gu Wenxing;Xia Yifeng;Zhang Jinping;Xu Yang;Zhong Zhiyuan
75 一种基于交联生物可降解聚合物囊泡的抗肿瘤纳米药物及其制备方法 专利 孟凤华;杨炜静;方媛;邹艳;钟志远
76 一种单靶向还原响应囊泡纳米药物在制备脑肿瘤治疗药物中的应用 专利 张建;钟志远;姜宇;史亚南;孟凤华
77 一种侧链含双碘功能基团的生物可降解聚合物及其应用 专利 钟志远;邹艳 孟凤华
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