以C5aR为新型胞内共刺激分子增强CAR-T抗白血病的基础与临床研究
81870121
2018
H0809.白血病
赖沛龙
面上项目
副主任医师
南方医科大学
55万元
共刺激分子结构域;PDX动物模型;C5a受体;Th17;嵌合抗原受体T细胞;细胞
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | 包含C3aR胞内结构域的嵌合抗原受体、慢病毒载体、表达细胞及药物 | 专利 | 杜欣;翁建宇;赖沛龙;陈晓梅 |
| 2 | 一种C5aR基因敲除小鼠cGVHD模型的建立方法 | 专利 | 杜欣;赖沛龙;翁建宇;王玉连;陈晓梅;黄欣 |
| 3 | The efficacy and safety of CAR-T cell therapy in patients with refractory ALL and concomitant HBV infection | 期刊论文 | Peilong Lai;Xiaomei Chen;Le Qin;Zhiwu Jiang;Chenwei Luo;Xin Huang;Sujing Wu;Wei Ling;Yulian Wang;Jinghua Wang;Chenxin Deng;Lisi Huang;Lingji Zeng;Zesheng Lu;Liye Zhong;Pengjun Liao;Minming Li;Dongmei Chen2;Suxia Geng;Ping Wu;Zhaoyang Tang;Duanqing Pei;Xin Du;Peng Li;Jianyu Weng |
| 4 | C3aR costimulation enhances the antitumor efficacy of CAR-T cell therapy through Th17 expansion and memory T cell induction | 期刊论文 | Peilong Lai;Xiaomei Chen;Yulian Wang;Jinghua Wang;Yuchen Zhang;Suxia Geng;Peng Li;Xin Du;Jianyu Weng;Duanqing Pei |
| 5 | Novel insights into MSC-EVs therapy for immune diseases | 期刊论文 | Peilong Lai;Jianyu Weng;Liyan Guo;Xiaomei Chen;Xin Du |
| 6 | Challenges and advances in clinical applications of mesenchymal stromal cells | 期刊论文 | Tian Zhou;Zenan Yuan;Jianyu Weng;Duanqing Pei;Xin Du;Chang He;Peilong Lai |
| 7 | 包含C5aR胞内结构域的嵌合抗原受体、慢病毒载体、表达细胞及药物 | 专利 | 赖沛龙 |
| 8 | Deep learning-based transcriptome model predicts survival of T-cell acute lymphoblastic leukemia | 期刊论文 | Lenghe Zhang;Lijuan Zhou;Yulian Wang;Chao Li;Pengjun Liao;Liye Zhong;Suxia Geng;Peilong Lai（共同通讯）;Xin Du;Jianyu Weng |
| 9 | The Gut Bacteria Dysbiosis Contributes to Chronic Graft-Versus-Host Disease Associated With a Treg/Th1 Ratio Imbalance | 期刊论文 | Yulian Wang;Lisi Huang;Tian Huang;Suxia Geng;Xiaomei Chen;Xin Huang;Peilong Lai（共同通讯）;Xin Du;Jianyu Weng |
| 10 | Extracellular vesicles from mesenchymal stem cells prevent contact hypersensitivity through the suppression of Tc1 and Th1 cells and expansion of regulatory T cells | 期刊论文 | Liyan Guo;Peilong Lai（共同第一）;Yulian Wang;Tian Huang;Xiaomei Chen;Chenwei Luo;Suxia Geng;Xin Huang;Suijing Wu;Wei Ling;Lisi Huang;Xin Du;Jianyu Weng |
| 11 | Extracellular vesicles derived from mesenchymal stem cells prevent skin fibrosis in the cGVHD mouse model by suppressing the activation of macrophages and B cells immune response | 期刊论文 | Liyan Guo;Peilong Lai （共同第一）;Yulian Wang;Tian Huang;Xiaomei Chen;Suxia Geng;Xin Huang;Chenwei Luo;Suijing Wu;Wei Ling;Lisi Huang;Xin Du;Jianyu Weng |
| 12 | 分泌IL-7的嵌合抗原受体、病毒载体、表达细胞及制备方法与药物 | 专利 | 翁建宇;陈晓梅;赖沛龙;杜欣;王玉连;王惊华;耿素霞 |
| 13 | A potent immunomodulatory role of exosomes derived from mesenchymal stromal cells in preventing cGVHD | 期刊论文 | Lai Peilong;Chen Xiaomei;Guo Liyan;Wang Yulian;Liu Xialin;Liu Yan;Zhou Tian;Huang Tian;Geng Suxia;Luo Chengwei;Huang Xin;Wu Suijing;Ling Wei;Du Xin;He Chang;Weng Jianyu |
| 14 | PICC导管患者专用服装 | 专利 | 赖沛龙;翁建宇;杜欣;张慈婵;黄立生;黄恬;陈晓梅;王玉连 |
| 15 | 一种检测CAR-T细胞数的方法 | 专利 | 赖沛龙;陈晓梅;翁建宇;杜欣 |
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