采用分子桥键化等策略构建高效稳定的α-螺旋型抗菌肽构效关系研究

81773564
2017
H3401.合成药物化学
倪京满
面上项目
教授
兰州大学
62万元
高稳定性;高活性;α-螺旋型抗菌肽;分子内/分子间桥键;非天然氨基酸置换
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Synthesis and anti-pseudomonal activity of new ß-Ala modified analogues of the antimicrobial peptide anoplin 期刊论文 Chao Zhong;Yuewen Zhu;Ningyi Zhu;Tianqi Liu;Sanhu Gou;Fangyan Zhang;Jia Yao;Junqiu Xie;Jingman Ni
2 Antimicrobial peptides with symmetric structures against multidrug- resistant bacteria while alleviating antimicrobial resistance 期刊论文 Chao Zhong;Fangyan Zhang;Jia Yao;Yunwen Zhu;Ningyi Zhu;Yun Zhang;Hui Liu;Sanhu Gou;Jingman Ni
3 Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice 期刊论文 Sanhu Gou;Beibei Li;Xu Ouyang;Zufang Ba;Chao Zhong;Tianyue Zhang;Linlin Chang;Yuewen Zhu;Jingying Zhang;Ningyi Zhu;Yun Zhang;Hui Liu;Jingman Ni
4 Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. 期刊论文 Sanhu Gou;Beibei Li;Xu Ouyang;Zufang Ba;Chao Zhong;Jingman Ni
5 Antimicrobial peptides conjugated with fatty acids on the side chain of D-amino acid promises antimicrobial potency against multidrug-resistant bacteria 期刊论文 Chao Zhong;Ningyi Zhu;Yuewen Zhu;Tianqi Liu;Sanhu Gou;Junqiu Xie;Jia Yao;Jingman Ni
6 A novel apoA-I mimetic peptide suppresses atherosclerosis by promoting physiological HDL function in apoE -/- mice. 期刊论文 Sanhu Gou;Li Wang;Chao Zhong;Xinyue Chen;Xu Ouyang;Beibei Li;Guangjun Bao;Hui Liu;Yun Zhang;Jingman Ni
7 Amphiphilic Endomorphin-1 Derivative Functions as Self-assembling Nanomedicine for Effective Brain Delivery 期刊论文 Hui Liu;Xiaoning Zhao;Shan Liang;Linlan Fan;Zhaojun Li;Yun Zhang;Jingman Ni
8 Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance 期刊论文 Chao Zhong;Fangyan Zhang;Ningyi Zhu;Yunwen Zhu;Jia Yao;Sanhu Gou;Junqiu Xie;Jingman Ni
9 New designed pH-responsive histidine-rich peptides with antitumor activity 期刊论文 Linlin Chang;Hexin Bao;Jia Yao;Hui Liu;Sanhu Gou;Chao Zhong;Yun Zhang;Jingman Ni
10 Effect of N-methylated and fatty acid conjugation on analogs of antimicrobial peptide Anoplin 期刊论文 Tianqi Liu;Ningyi Zhu;Chao Zhong;Yunwen Zhu;Sanhu Gou;Linlin Chang;Hexin Bao;Hui Liu;Yun Zhang;Jingman Ni
11 Study on the effects of different dimerization positions on biological activity of partial d-Amino acid substitution analogues of Anoplin 期刊论文 Chao Zhong;Sanhu Gou;Tianqi Liu;Yunwen Zhu;Ningyi Zhu;Hui Liu;Yun Zhang;Junqiu Xie;Xiaomin Guo;Jingman Ni
12 New Antimicrobial Peptides with Repeating Unit against Multidrug-Resistant Bacteria. 期刊论文 Chao Zhong;Fangyan Zhang;Jia Yao;Yunwen Zhu;Ningyi Zhu;Jingying Zhang;Xu Ouyang;Tianyue Zhang;Beibei Li;Junqiu Xie;Jingman Ni
13 Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity 期刊论文 Chao Zhong;Tianqi Liu;Sanhu Gou;Yongtao He;Ningyi Zhu;Yuewen Zhu;Li Wang;Hui Liu;Yun Zhang;Jia Yao;Jingman Ni
14 Design of a new pH‐activatable cell‐penetrating peptide for drug delivery into tumor cells 期刊论文 Yun Zhang;Li Li;Linlin Chang;Hui Liu;Jingjing Song;Yue Liu;Hexin Bao;Beijun Liu;Rui Wang;Jingman Ni
15 Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria 期刊论文 Ningyi Zhu;Chao Zhong;Tianqi Liu;Yunwen Zhu;Sanhu Gou;Hexin Bao;Jia Yao;Jingman Ni
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