以神经肽为模板的大麻/神经肽FF受体多靶点分子的化学构建和无耐受镇痛作用研究

81673282
2016
H3401.合成药物化学
方泉
面上项目
教授
兰州大学
54万元
镇痛药物;神经肽;肽结构改造;镇痛耐受;多靶点药物
2017-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Preemptive intrathecal administration of endomorphins relieves inflammatory pain in male mice via inhibition of p38 MAPK signaling and regulation of inflammatory cytokines. 期刊论文 Zhang Ting;Zhang Nan;Zhang Run;Zhao Weidong;Chen Yong;Wang Zilong;Xu Biao;Zhang Mengna;Shi Xuerui;Zhang Qinqin;Guo Yuanyuan;Xiao Jian;Chen Dan;Fang Quan
2 Synthesis and biological characterization of cyclic disulfide-containing peptide analogs of the multifunctional opioid/neuropeptide FF receptors agonist that produced long-lasting and nontolerant antinociception 期刊论文 Zhang MN;Xu B;Li N;Liu H;Shi XR;Zhang QQ;Shi YB;Xu KT;Xiao J;Chen D;Zhu HW;Sun YL;Zhang T;Zhang R;Fang Q
3 多肽药物的规模化和机械化制备技术创新及应用 奖励 王锐;崔学云;杨顶建;常民;方泉;胡晓愚;杨平;彭雅丽;倪京满;姜月霞;张邦治
4 多肽化学修饰的关键技术及其在多肽新药创制中的应用 奖励 王锐;袁建成;方泉;马亚平;刘建;张邦治
5 Peripheral and central sites of action for anti-allodynic activity induced by the bifunctional opioid/NPFF receptors agonist BN-9 in inflammatory pain model. 期刊论文 Zhang Run;Xu Biao;Zhang Meng-Na;Zhang Ting;Wang Zi-Long;Zhao Geng;Zhao Guang-Hai;Li Ning;Fang Quan;Wang Rui
6 一种基于大麻肽(r)VD-Hpα和神经肽FF的嵌合肽及其制备方法与应用 专利 方泉;许彪;张梦娜;张润;李宁
7 The multifunctional peptide DN-9 produced peripherally acting antinociception in inflammatory and neuropathic pain via mu and kappa opioid receptors 期刊论文 Xu B;Zhang MN;Shi XR;Zhang R;Chen D;Wang ZL;Qiu Y;Zhang T;Xu KT;Zhang XY;Liedtke W;Wang R;Fang Q
8 Central and peripheral modulation of gastrointestinal transit in mice by DN-9, a multifunctional opioid/NPFF receptor agonist 期刊论文 Xu B;Guo YY;Zhang MN;Zhang R;Chen D;Zhang QQ;Xiao J;Xu KT;Li N;Qiu Y;Zhu HW;Niu JD;Zhang XY;Fang Q
9 Pharmacological characterization of rat VD-hemopressin(α), an α-hemoglobin-derived peptide exhibiting cannabinoid agonist-like effects in mice. 期刊论文 Zheng Ting;Zhang Ting;Zhang Run;Wang Zi-long;Han Zheng-lan;Li Ning;Li Xu-hui;Zhang Meng-na;Xu Biao;Yang Xiong-li;Fang Quan;Wang Rui
10 Systemic administration of the bifunctional opioid/neuropeptide FF receptors agonist BN-9 produced peripheral antinociception in preclinical mouse models of pain. 期刊论文 Li Ning;Han Zheng-Lan;Xu Biao;Zhang Meng-Na;Zhang Ting;Shi Xue-Rui;Zhao Wei-Dong;Guo Yuan-Yuan;Zhang Qin-Qin;Fang Quan
11 Spinal DN-9, a peptidic multifunctional opioid/neuropeptide FF agonist produced potent nontolerance forming analgesia with limited side effects 期刊论文 Wang ZL;Xu B;Jiang CY;Zhang T;Zhang MN;Li N;Zhang QQ;Xu KT;Chen D;Xiao J;Fang Q
12 一类阿片和神经肽FF受体多靶点分子BN-9的类似物及其制备方法与应用 专利 方泉;张梦娜;王锐;许彪;石学睿
13 Discovery of two novel branched peptidomimetics containing endomorphin-2 and RF9 pharmacophores: Synthesis and neuropharmacological evaluation. 期刊论文 Zhang Ting;Han Zhenglan;Shi Xuerui;Zhao Weidong;Wang Zilong;Zhang Run;Xu Biao;Zhang Mengna;Zhang Qinqin;Xiao Jian;Zhu Hanwen;Zheng Ting;Fang Quan
14 一类阿片和神经肽FF受体的多靶点肽类分子及其制备和应用 专利 王锐;方泉;王子龙
15 一类阿片和神经肽FF受体多靶点肽类分子BN-9的二硫键环化类似物及其制备方法和应用 专利 方泉;张梦娜;王锐;许彪;石学睿
16 Spinal administration of the multi-functional opioid/neuropeptide FF agonist BN-9 produced potent antinociception without development of tolerance and opioid-induced hyperalgesia 期刊论文 Zhang R;Xu B;Zhang QQ;Chen D;Zhang MN;Zhao GH;Xu KT;Xiao J;Zhu HW;Niu JD;Li N;Fang Q
17 Antinociceptive effects of the endogenous cannabinoid peptide agonist VD-hemopressin(beta) in mice. 期刊论文 Wang Pei;Zheng Ting;Zhang Mengna;Xu Biao;Zhang Run;Zhang Ting;Zhao Weidong;Shi Xuerui;Zhang Qinqin;Fang Quan
18 VF-13, a chimeric peptide of VD-hemopressin(α) and neuropeptide VF, produces potent antinociception with reduced cannabinoid-related side effects 期刊论文 Xu B;Xiao J;Xu KT;Zhang QQ;Chen D;Zhang R;Zhang MN;Zhu HW;Niu JD;Zheng T;Li N;Zhang XY;Fang Q
19 CB1 cannabinoid receptor agonist mouse VD-hemopressin(alpha) produced supraspinal analgesic activity in the preclinical models of pain. 期刊论文 Zheng Ting;Zhang Run;Zhang Ting;Zhang Meng-Na;Xu Biao;Song Jing-Jing;Li Ning;Tang Hong-Hai;Wang Pei;Wang Rui;Fang Quan
20 GpTx-1 and [Ala(5) , Phe(6) , Leu(26) , Arg(28) ]GpTx-1, two peptide NaV 1.7 inhibitors: analgesic and tolerance properties at the spinal level. 期刊论文 Chen Chao;Xu Biao;Shi Xuerui;Zhang Mengna;Zhang Qinqin;Zhang Ting;Zhao Weidong;Zhang Run;Wang Zilong;Li Ning;Fang Quan
21 Analgesic activities of the mixed opioid and NPFF receptors agonist DN-9 in a mouse model of formalin-induced orofacial inflammatory pain. 期刊论文 Zhang Ting;Zhao Weidong;Zhang Mengna;Xu Biao;Shi Xuerui;Zhang Qinqin;Guo Yuanyuan;Xiao Jian;Chen Dan;Zheng Ting;Fang Quan
22 多靶点肽类镇痛药物的研究进展 期刊论文 方泉;李宁;王锐
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