分子靶向与电荷屏蔽协同修饰的新型低毒抗菌肽及其抗肿瘤应用

81202400
2012
H3401.合成药物化学
张邦治
青年科学基金项目
教授
兰州大学
23万元
电荷屏蔽;抗菌肽;抗肿瘤;低毒性;分子靶向
2013-01-01到2015-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Catalytic asymmetric Michael reaction of 5H-oxazol-4-ones with alpha,beta-unsaturated acyl imidazoles 期刊论文 Yang Junxian|Li Xiaofang|Zhao Depeng|Wang Rui|
2 Membrane active antimicrobial activity and molecular dynamics study of a novel cationic antimicrobial peptide polybia-MPI, from the venom of Polybia paulista 期刊论文 Wenjin Yan|Zhibin Yang|Junqiu Xie|Rui Wang|
3 Two hits are better than one: membrane-active and DNA binding-related double-action mechanism of NK-18, a novel antimicrobial peptide derived from mammalian NK-lysin. 期刊论文 Xie Junqiu|Zhang Bangzhi|Song Jingjing|Wang Rui|
4 多肽药物先导化合物的化学筛选和作用机制研究 奖励
5 酸激活多肽的设计及抗肿瘤应用 会议论文
6 Design of novel analogues of short antimicrobial peptide anoplin with improved antimicrobial activity 期刊论文 Ma Panpan|Cai Ying|Zhang Bangzhi|Chen Yuan|
7 Cell penetrating peptide TAT can kill cancer cells via membrane disruption after attachment of camptothecin 期刊论文 Zhang Bangzhi|Liu Beijun|Ni Jingman|Wang Rui|
8 Design of an acid-activated antimicrobial peptide for tumor therapy 期刊论文 Zhang Yun|Yang Zhibin|Ni Jingman|Wang Rui|
9 Catalytic desymmetrization of meso-aziridines with benzofuran-2(3H)-ones employing a simple in situ-generated magnesium catalyst 期刊论文 Wang Linqing|Yang Dongxu|Zhang Bangzhi|Wang Rui|
10 Two hits are better than one: membrane-active and DNA binding-related double-action mechanism of NK-18, a novel antimicrobial peptide derived from mammalian NK-lysin. 期刊论文 Xie Junqiu|Zhang Bangzhi|Song Jingjing|Wang Rui|
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