羧酸酯酶调控剂的高通量高内涵筛选与评价体系及其应用
81803489
2018
H3410.药物分析
金强
青年科学基金项目
助理研究员
上海中医药大学
21万元
羧酸酯酶;抑制剂/诱导剂;高内涵筛选;活细胞;天然产物
2019-01-01到2021-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Discovery of natural pentacyclic triterpenoids as potent and selective inhibitors against human carboxylesterase 1 | 期刊论文 | Song Pei Fang;Zhu Ya Di;Ma Hong Ying;Wang Yi Nan;Wang Dan Dan;Zou Li Wei;Ge Guang Bo;Yang Ling |
| 2 | Anthraquinones from Cassiae semen as thrombin inhibitors: in vitro and in silico studies | 期刊论文 | Yu Xiao;Wei Ling Hua;Zhang Jia Kai;Chen Tian Ran;Jin Qiang;Wang Yi Nan;Zhang Shui Jun;Dau Tong Yi;Cao Yun Feng;Guo Wen Zhi;Ge Guang Bo;Yang Ling |
| 3 | Differences in susceptibility of HT‐29 and A549 cells to statin‐induced toxicity: An investigation using high content screening | 期刊论文 | Guilin Wei;Lijuan Xue;Yadi Zhu;Xingkai Qian;Liwei Zou;Qiang Jin;Dandan Wang;Guangbo Ge |
| 4 | Discovery of a highly specific and efficacious inhibitor of human carboxylesterase 2 by large-scale screening | 期刊论文 | Song Yun Qing;Guan Xiao Qing;Weng Zi Miao;Wang Ya Qiao;Chen Jing;Jin Qiang;Fang Sheng Quan;Fan Bin;Cao Yun Feng;Hou Jie;Ge Guang Bo |
| 5 | 1-环己基吡唑啉酮类羧酸酯酶1抑制剂、及其制备及应用 | 专利 | 邹立伟;王丹丹;钱星凯;张静;杨凌;葛广波;金强;宋培放 |
| 6 | Discovery of natural alkaloids as potent and selective inhibitors against human carboxylesterase 2 | 期刊论文 | Yi-Shu Zhao;Xing-Kai Qian;Xiao-Qing Guan;Pei-Fang Song;Yun-Qing Song;Rong-Jing He;Meng-Ru Sun;Xiu-Yang Wang;Li-Wei Zou;Guang-Bo Ge |
| 7 | Sensing cytochrome P450 1A1 activity by a resorufin-based isoform-specific fluorescent probe | 期刊论文 | Jin Qiang;Ma Hongying;Feng Lei;Wang Ping;He Rongjing;Ning Jing;Yang Ling;Ge Guangbo |
| 8 | Inhibition of human carboxylesterases by magnolol: kinetic analyses and mechanism | 期刊论文 | Yun-Qing Song;Zi-Miao Weng;Tong-Yi Dou;Moshe Finel;Ya-Qiao Wang;Le-Le Ding;Qiang Jin;Dan-Dan Wang;Sheng-Quan Fang;Yun-Feng Cao;Jie Ho;GuangBo Ge |
| 9 | Bioluminescent Sensor Reveals that Carboxylesterase 1A is a Novel Endoplasmic Reticulum-Derived Serologic Indicator for Hepatocyte Injury | 期刊论文 | Dan-Dan Wang;Li-Wei Zou;Qiang Jin;Xiao-Qing Guan;Yang Yu;Ya-Di Zhu;Jian Huang;Peng Gao;Ping Wang;Guang-Bo Ge;Ling Yang |
| 10 | Carboxylesterase inhibitors from clinically available medicines and their impact on drug metabolism | 期刊论文 | Yun-Qing Song;Qiang Jin;Dan-Dan Wang;Jie Hou;Li-Wei Zou;Guang-Bo Ge |
| 11 | Natural constituents of St. John's Wort inhibit the proteolytic activity of human thrombin | 期刊论文 | Ling-Hua Wei;Tian-Ran Chen;Hong-Bo Fang;Qiang Jin;Shui-Jun Zhang;Jie Hou;Yang Yu;Tong-Yi Dou;Yun-Feng Cao;Wen-Zhi Guo;Guang-Bo Ge |
| 12 | Construction and application of a high-content analysis for identifying human carboxylesterase 2 inhibitors in living cell system | 期刊论文 | Xue Lijuan;Qian Xingkai;Jin Qiang;Zhu Yadi;Wang Xiaoyu;Wang Dandan;Ge Guangbo;Yang Ling |
| 13 | Discovery of pyrazolones as novel carboxylesterase 2 inhibitors that potently inhibit the adipogenesis in cells | 期刊论文 | Xing-Kai Qian;Jing Zhang;Pei-Fang Song;Yi-Su Zhao;Hong-Ying Ma;Qiang Jin;Dan-Dan Wang;Xiao-Qing Guan;Shi-Yang Li;XiaoZe Bao;Li-Wei Zou |
| 14 | 线粒体损伤介导的药源性脏器损伤评价模型研究进展 | 期刊论文 | 魏桂林;何青青;金强;杨凌 |
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