基于蛋白质组学与代谢组学联用技术探讨桑叶治疗2型糖尿病作用机制及信号元件交互作用
81773960
2017
H3211.中药内分泌与代谢药理
赵保胜
面上项目
研究员
北京中医药大学
55万元
蛋白质组学;2型糖尿病;作用机制及交互作用;代谢组学;桑叶
2018-01-01到2021-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Research progress on Traditional Chinese Medicine syndromes of diabetes mellitus | 期刊论文 | Jingkang Wang;Quantao Ma;Yaqi Li;Pengfei Li;Min Wang;Tieshan Wang;Chunguo Wang;Ting Wang;Baosheng Zhao |
| 2 | Brown and beige adipose tissue: a novel therapeutic strategy for obesity and type 2 diabetes mellitus | 期刊论文 | Long Cheng;Jingkang Wang;Hongyu Dai;Yuhui Duan;Yongcheng An;Lu Shi;Yinglan Lv;Huimin Li;Chen Wang;Quantao Ma;Yaqi Li;Pengfei Li;Haifeng Du;Baosheng Zhao |
| 3 | Research progress in the relationship between type 2 diabetes mellitus and intestinal flora | 期刊论文 | Ma Quantao;Li Yaqi;Li Pengfei;Wang Min;Wang Jingkang;Tang Ziyan;Wang Ting;Luo Linglong;Wang Chunguo;Zhao Baosheng |
| 4 | Aqueous extract of Mori Folium exerts bone protective effect through regulation of calcium and redox homeostasis via PTH/VDR/CaBP and AGEs/RAGE/Nox4/NF-κB signaling in diabetic rats | 期刊论文 | Liu C;Zhu R;Liu H;Li L;Chen B;Jia Q;Wang L;Ma R;Tian S;Wang M;Fu M and;Niu J;Orekhov AN;Gao S;Zhang D;Zhao B |
| 5 | Relationship between hyperlipidemia and the gut microbiome of rats, characterized using high-throughput sequencing | 期刊论文 | Yaqi Li;Quantao Ma;Jingkang Wang;Pengfei Li;Long Cheng;Yongcheng An;Yuhui Duan;Hongyu Dai;Ting Wang;Baosheng Zhao |
| 6 | Investigation of gut microbiome changes in type 1 diabetic mellitus rats based on high-throughput sequencing | 期刊论文 | Ma Quantao;Li Yaqi;Wang Jingkang;Li Pengfei;Duan Yuhui;Dai Hongyu;An Yongcheng;Cheng Long;Wang Tieshan;Wang Chunguo;Wang Ting;Zhao Baosheng |
| 7 | 桑叶调节PI3K/Akt/PPARα/CPT-1通路改善2型糖尿病大鼠肝脏糖脂代谢紊乱机制 | 期刊论文 | 代泓钰;王敬康;王晨;石璐;段钰卉;安永铖;吕迎兰;李慧敏;程龙;何昶昊;张慧琳;黄艳;付宛鑫;刘珍清;赵保胜 |
| 8 | Proteomics reveals different pathological processes of adipose tissue, liver and skeletal muscle under insulin resistance | 期刊论文 | Yaqi Li;Quantao Ma;Pengfei Li;Jingkang Wang;Min Wang;Yuanyuan Fan;Tieshan Wang ;Chunguo Wang;Ting Wang;Baosheng Zhao |
| 9 | Mulberry leaf activates brown adipose tissue and induces browning of inguinal white adipose tissue in type 2 diabetic rats through regulating AMPK signaling pathway | 期刊论文 | Long Cheng;Jingkang Wang;Yongcheng An;Hongyu Dai;Yuhui Duan;Lu Shi;Yinglan Lv;Huimin Li;Chen Wang;Haifeng Du;Xiaoqing Zhong;Baosheng Zhao |
| 10 | 桑叶对2型糖尿病大鼠肝脏Toll样受体及其下游信号元件基因表达的影响 | 期刊论文 | 王敏;马全涛;李亚琪;柳辰玥;张驰;邱敏懿;张彩娟;王停;赵保胜;李红燕 |
| 11 | Progress in metabonomics of type 2 diabetes mellitus | 期刊论文 | Quantao Ma;Yaqi Li;Min Wang;Ziyan Tang;Ting Wang;Chenyue Liu;Chunguo Wang;Baosheng Zhao |
| 12 | 桑叶改善3T3-L1细胞胰岛素抵抗的作用及其机制分析 | 期刊论文 | 王敏;李亚琪;马全涛;柳辰玥;张驰;邱敏懿;张彩娟;王停;赵保胜 |
| 13 | Mulberry leaf reduces inflammation and insulin resistance in type 2 diabetic mice by TLRs and insulin signalling pathway | 期刊论文 | Simin Tian;Min Wang;Chenyue Liu;Hongbin Zhao;Baosheng Zhao |
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