E3泛素化连接酶WWP2在血管内皮损伤中的作用及其机制研究
81970211
2019
H0202.心肌损伤、修复、重构和再生
孙英贤
面上项目
教授
中国医科大学
55万元
WW结构域包含蛋白2;氧化应激;血管内皮损伤;细胞分裂/GTP结合蛋白4;泛素化修饰
2020-01-01到2023-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | 高血压及其相关疾病靶器官保护策略的基础研究及转化应用 | 奖励 | 孙英贤;张乃今;张莹;孙国哲;李昭;徐礼胜;叶宁;成正辉;郭潇繁;王军;周颖 |
| 2 | Deacetylation of Septin4 by SIRT2 (Silent Mating Type Information Regulation 2 Homolog-2) Mitigates Damaging of Hypertensive Nephropathy | 期刊论文 | Ying Zhang;Naijin Zhang;Yuanming Zou;Chunyu Song;Kexin Cao;Boquan Wu;Shilong You;Saien Lu;Dong Wang;Jiaqi Xu;Xinyue Huang;Pengyu Zhang;Zihao Fan;Jingwei Liu;Zhongyi Cheng;Zhe Zhang;Chuize Kong;Liu Cao;Yingxian Sun |
| 3 | Neutrophil extracellular traps accelerate vascular smooth muscle cell proliferation via Akt/CDKN1b/TK1 accompanying with the occurrence of hypertension. | 期刊论文 | Xinhui Fang;Ling Ma;Yanfu Wang;Fang Ren;Yanqiu Yu;Zhengwei Yuan;Hongquan Wei;Haipeng Zhang;Yingxian Sun |
| 4 | Paired box 9 regulates VSMC phenotypic transformation, proliferation, and migration via sonic hedgehog | 期刊论文 | Xu Jiaqi;Zhang Ying;You Shilong;Guo Yuxuan;Chen Shuang;Chang Ye;Zhang Naijin;Sun Yingxian |
| 5 | Regulation of the Tec family of non-receptor tyrosine kinases in cardiovascular disease | 期刊论文 | Zeyu Yin;Yuanming Zou;Dong Wang;Xinyue Huang;Shengjun Xiong;Liu Cao;Ying Zhang;Yingxian Sun;Naijin Zhang |
| 6 | The role of SMURFs in non‐cancerous diseases | 期刊论文 | Dong Wang;Yuanming Zou;Xinyue Huang;Zeyu Yin;Mohan Li;Jiaqi Xu;Boquan Wu;Da Li;Ying Zhang;Yingxian Sun;Xingang Zhang;Naijin Zhang |
| 7 | α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure | 期刊论文 | Naijin Zhang;Ying Zhang;Jiaqi Xu;Pengbo Wang;Boquan Wu;Saien Lu;Xinxin Lu;Shilong You;Xinyue Huang;Mohan Li;Yuanming Zou;Mengke Liu;Yuanhui Zhao;Guozhe Sun;Wenbin Wang;Danxi Geng;Jingwei Liu;Liu Cao;Yingxian Sun |
| 8 | Septin4 Prevents PDGF-BB-induced HAVSMC Phenotypic Transformation, Proliferation and Migration by Promoting SIRT1-STAT3 Deacetylation and Dephosphorylation | 期刊论文 | Zhang Naijin;Zhang Ying;You Shilong;Tian Yichen;Lu Saien;Cao Liu;Sun Yingxian |
| 9 | Septin4 as an autophagy modulator regulates Angiotensin-II mediated VSMCs proliferation and migration | 期刊论文 | Ning Wang;Feng Xu;Saien Lu;Naijin Zhang;Yingxian Sun |
| 10 | Atorvastatin rescues vascular endothelial injury in hypertension by WWP2-mediated ubiquitination and degradation of ATP5A | 期刊论文 | Zeyu Yin;Shilong You;Shu Zhang;Linlin Zhang;Boquan Wu;Xinyue Huang;Saien Lu;Liu Cao;Ying Zhang;Da Li;Xingang Zhang;Jingwei Liu;Yingxian Sun;Naijin Zhang |
| 11 | Deacetylation-dependent regulation of PARP1 by SIRT2 dictates ubiquitination of PARP1 in oxidative stress-induced vascular injury | 期刊论文 | Naijin Zhang;Ying Zhang;Boquan Wu;Shaojun Wu;Shilong You;Saien Lu;Jingwei Liu;Xinyue Huang;Jiaqi Xu;Liu Cao;Yingxian Sun |
| 12 | Spleen tyrosine kinase (SYK) signals are implicated in cardio-cerebrovascular diseases | 期刊论文 | Mohan Li;Pengbo Wang;Yuanming Zou;Wenbin Wang;Yuanhui Zhao;Mengke Liu;Jianlong Wu;Ying Zhang;Naijin Zhang;Yingxian Sun |
| 13 | DNA Polymerase Gamma Recovers Mitochondrial Function and Inhibits Vascular Calcification by Interacted with p53 | 期刊论文 | Pengbo Wang;Boquan Wu;Shilong You;Saien Lu;Shengjun Xiong;Yuanming Zou;Pengyu Jia;Xiaofan Guo;Ying Zhang;Liu Cao;Yingxian Sun;Naijin Zhang |
| 14 | Research progress of Nedd4L in cardiovascular diseases | 期刊论文 | Mohan Li;Guozhe Sun;Pengbo Wang;Wenbin Wang;Kexin Cao;Chunyu Song;Yingxian Sun;Ying Zhang;Naijin Zhang |
| 15 | Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling | 期刊论文 | Naijin Zhang;Ying Zhang;Hao Qian;Shaojun Wu;Liu Cao;Yingxian Sun |
| 16 | Role of WW domain E3 ubiquitin protein ligase 2 in modulating ubiquitination and Degradation of Septin4 in oxidative stress endothelial injury | 期刊论文 | Naijin Zhang;Ying Zhang;Boquan Wu;Shilong You;Yingxian Sun |
| 17 | The Role of BRG1 in Antioxidant and Redox Signaling | 期刊论文 | Shilong You;Ying Zhang;Jiaqi Xu;Hao Qian;Shaojun Wu;Boquan Wu;Saien Lu;Yingxian Sun;Naijin Zhang |
| 18 | WWP2 regulates SIRT1-STAT3 acetylation and phosphorylation involved in hypertensive angiopathy | 期刊论文 | Zhang Ying;You Shilong;Tian Yichen;Lu Saien;Cao Liu;Sun Yingxian;Zhang Naijin |
| 19 | BAF155 promotes cardiac hypertrophy and fibrosis through inhibition of WWP2-mediated PARP1 ubiquitination | 期刊论文 | Naijin Zhang;Ying Zhang;Yong Chen;Hao Qian;Boquan Wu;Saien Lu;Shilong You;Wancheng Xu;Yuanming Zou;Xinyue Huang;Wenbin Wang;Jingwei Liu;Da Li;Liu Cao;Yingxian Sun |
| 20 | The role of SIRT2 in vascular‐related and heart‐related diseases: A review | 期刊论文 | Boquan Wu;Shilong You;Hao Qian;Shaojun Wu;Saien Lu;Ying Zhang;Yingxian Sun;Naijin Zhang |
| 21 | Comprehensive Bioinformatics Analysis Identifies POLR2I as a Key Gene in the Pathogenesis of Hypertensive Nephropathy | 期刊论文 | Shilong You;Jiaqi Xu;Boquan Wu;Shaojun Wu;Ying Zhang;Yingxian Sun;Naijin Zhang |
| 22 | An unexpected role for BAG3 in regulating PARP1 ubiquitination in oxidative stress-related endothelial damage | 期刊论文 | Naijin Zhang;Ying Zhang;Wei Miao;Chuning Shi;Zihan Chen;Boquan Wu;Yuanming Zou;Qiushi Ma;Shilong You;Saien Lu;Xinyue Huang;Jingwei Liu;Jiaqi Xu;Liu Cao;Yingxian Sun |
| 23 | Different roles of BAG3 in cardiac physiological hypertrophy and pathological remodeling. | 期刊论文 | Pengyu Jia;Nan Wu;Huimin Yang;Yuxuan Guo;Xiaofan Guo;Yingxian Sun |
| 24 | Down-regulation of WWP2 aggravates Type 2 diabetes mellitus-induced vascular endothelial injury through modulating ubiquitination and degradation of DDX3X | 期刊论文 | Shilong You;Jiaqi Xu;Zeyu Yin;Boquan Wu;Pengbo Wang;Mingjun Hao;Cheng Cheng;Mengke Liu;Yuanhui Zhao;Pengyu Jia;Hongkun Jiang;Da Li;Liu Cao;Xingang Zhang;Ying Zhang;Yingxian Sun;Naijin Zhang |
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