多级手性“硅纳米螺丝”递药系统的设计及其依托拓扑结构跨越生理屏障的机制研究

81903550
2019
H3408.药剂学
李鹤然
青年科学基金项目
副教授
中国医科大学
21万元
手性硅纳米螺丝;口服吸收;药剂学;介孔二氧化硅;药物递送
2020-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Amino functionalized mesoporous silica with twisted rod-like shapes: Synthetic design, in vitro and in vivo evaluation for ibuprofen delivery 期刊论文 Yumei Wang;Jia Ke;Kaijun Gou;Yingyu Guo;Xiaomin Xu;Sanming Li;Heran Li
2 Carboxyl-functionalized mesoporous silica nanoparticles for the controlled delivery of poorly water-soluble non-steroidal anti-inflammatory drugs 期刊论文 Kaijun Gou;Yumei Wang;Xianmou Guo;Yuxin Wang;Yan Bian;Haiqing Zhao;Yingyu Guo;Yue Pang;Linlin Xie;Sanming Li;Heran Li
3 Synthesis and characterization of core-shell mesoporous silica nanoparticles with various shell thickness as indomethacin carriers: in vitro and in vivo evaluation 期刊论文 Jia Ke;Yumei Wang;Lingmei Wang;Baixue Yang;Kaijun Gou;Yanxin Qin;Sanming Li;Heran Li
4 Mesoporous silica nanoparticles with chiral pattern topological structure function as “antiskid tires” on the intestinal mucosa to facilitate oral drugs delivery 期刊论文 Heran Li
5 pH/H2O2 Dual-Responsive Chiral Mesoporous Silica Nanorods Coated with a Biocompatible Active Targeting Ligand for Cancer Therapy 期刊论文 Yumei Wang;Jing Wang;Kaijun Gou;Wei Kang;Xianmou Guo;Keyu Zhu;Sanming Li;Heran Li
6 Functional mesoporous silica nanoparticles for delivering nimesulide with chiral recognition performance 期刊论文 Yingyu Guo;Lulu Wu;Kaijun Gou;Yumei Wang;Baichun Hu;Yue Pang;Sanming Li;Heran Li
7 Chiral microenvironment-responsive mesoporous silica nanoparticles for delivering indometacin with chiral recognition function 期刊论文 Kaijun Gou;Xianmou Guo;Yumei Wang;Zhentao Sang;Shuangshuang Ma;Yingyu Guo;Linlin Xie;Sanming Li;He Li
8 Enlarged Pore Size Chiral Mesoporous Silica Nanoparticles Loaded Poorly Water-Soluble Drug Perform Superior Delivery Effect 期刊论文 Yingyu Guo;Kaijun Gou;Baixue Yang;Yumei Wang;Xueyu Pu;Sanming Li;Heran Li
9 Chiral mesoporous silica nano-screws as an efficient biomimetic oral drug delivery platform through multiple topological mechanisms 期刊论文 Yumei Wang;Jia Ke;Xianmou Guo;Kaijun Gou;Zhentao Sang;Yanbu Wang;Yan Bian;Sanming Li;Heran Li
10 Biomimetic aminoated mesoporous silica xerogel exhibiting chiral surface topology for delivery insoluble drug with multiple-controlled manners and improved oral adsorption 期刊论文 Xianmou Guo;Kaijun Gou;Yang Han;Qi Pan;Yuxin Wang;Shun Zong;Jiexin Song;Xuchun Chen;Heran Li
11 Dual response to pH and chiral microenvironments for the release of a flurbiprofen-loaded chiral self-assembled mesoporous silica drug delivery system 期刊论文 Lulu Wu;Kaijun Gou;Xianmou Guo;Yingyu Guo;Muyun Chen;Jinxin Hou;Sanming Li;Heran Li
12 Chiral Nanosilica Drug Delivery Systems Stereoselectively Interacted with the Intestinal Mucosa to Improve the Oral Adsorption of Insoluble Drugs 期刊论文 Xuchun Chen;Ying Cheng;Qi Pan;Lan Wu;Xinyao Hao;Zhiye Bao;Xitan Li;Mingshi Yang;Qiuhua Luo;Heran Li
13 Biomimetic Synthesis and Evaluation of Interconnected Bimodal Mesostructured MSF@Poly(Ethyleneimine)s for Improved Drug Loading and Oral Adsorption of the Poorly Water-Soluble Drug, Ibuprofen 期刊论文 Wei Xin;Yumei Wang;Xianmou Guo;Kaijun Gou;Jing Li;Sanming Li;Lin Zhao;Heran Li
14 Facile synthesis of PEI-based crystalline templated mesoporous silica with molecular chirality for improved oral delivery of the poorly water-soluble drug 期刊论文 Wei Xin;Yumei Wang;Yan Bian;Jiahui Lin;Wenhao Weng;Xinyi Zhao;Kaijun Gou;Xianmou Guo;Heran Li
15 Superiority of L-tartaric Acid Modified Chiral Mesoporous Silica Nanoparticle as a Drug Carrier: Structure, Wettability, Degradation, Bio-Adhesion and Biocompatibility. 期刊论文 Beibei Hu;Jianxin Wang;Jing Li;Sanming Li;Heran Li
16 Synthesis, structural properties, biosafety and applications of chiral mesoporous silica nanostructures 期刊论文 Kaijun Gou;Yumei Wang;Linlin Xie;Xianmou Guo;Yingyu Guo;Jia Ke;Lulu Wu;Sanming Li;Heran Li
17 Advances in regulating physicochemical properties of mesoporous silica nanocarriers to overcome biological barriers 期刊论文 Yumei Wang;Kaijun Gou;Xianmou Guo;Jia Ke;Sanming Li;Heran Li
18 Biomimetic Virus-like Mesoporous Silica Nanoparticles Improved Cellular Internalization for Co-delivery of Antigen and Agonist to Enhance Tumor Immunotherapy 期刊论文 Heran Li
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