宫内羊膜腔注射移植的干细胞向神经管畸形病变部位定向迁移的分子机制研究及其远期神经功能恢复的效果评价

81871219
2018
H0422.生殖系统/围生医学/新生儿疾病研究新技术与新方法
袁正伟
面上项目
教授
中国医科大学
57万元
产前治疗;干细胞;蛋白组学;神经管畸形;生殖缺陷诊疗技术
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 The miR-532-3p/Chrdl1 axis regulates the proliferation and migration of amniotic fluid-derived mesenchymal stromal cells 期刊论文 Jieting Huang;Xiaowei Wei;Wei Ma;Zhengwei Yuan
2 Role and mechanisms of the NF-ĸB signaling pathway in various developmental processes. 期刊论文 Peiqi Liu;Yue Li;Weilin Wang;Yuzuo Bai;Huimin Jia;Zhengwei Yuan;Zhonghua Yang
3 Bhlhe40/Sirt1 Axis-Regulated Mitophagy Is Implicated in All-Trans Retinoic Acid-Induced Spina Bifida Aperta 期刊论文 Lu Zhao;Dan Liu;Wei Ma;Hui Gu;Xiaowei Wei;Wenting Luo;Zhengwei Yuan
4 Maternal serum Lamin A is a potential biomarker that can predict adverse pregnancy outcomes 期刊论文 Lizhu Chen;Yun Xiu;Qijun Wu;Yu Wang;Yixin Zhang;Jia Xue;Qinbo Wang;Zhengwei Yuan
5 Transcriptome analysis reveals the spinal expression profiles of non-coding RNAs involved in anorectal malformations in rat fetuses 期刊论文 Yue Li;Peiqi Liu;Weilin Wang;Yuzuo Bai;Huimin Jia;Zhengwei Yuan;Zhonghua Yang
6 PIWI-interacting RNA sequencing profiles in maternal plasma-derived exosomes reveal novel non-invasive prenatal biomarkers for the early diagnosis of nonsyndromic cleft lip and palate 期刊论文 Jia Shanshan;Zhang Qiang;Wang Yu;Wang Yanfu;Liu Dan;He Yiwen;Wei Xiaowei;Gu Hui;Ma Wei;Luo Wenting;Yuan Zhengwei
7 Intra-amniotic transplantation of brain-derived neurotrophic factor-modified mesenchymal stem cells treatment for rat fetuses with spina bifida aperta 期刊论文 Wei Ma;Xiaowei Wei;Hui Gu;Dan Liu;Wenting Luo;Songying Cao;Shanshan Jia;Yiwen He;Lizhu Chen;Yuzuo Bai;Zhengwei Yuan
8 miR-322 treatment rescues cell apoptosis and neural tube defect formation through silencing NADPH oxidase 4 期刊论文 Liu Yu-si;Gu Hui;Huang Tian-chu;Wei Xiao-wei;Ma Wei;Liu Dan;He Yi-wen;Luo Wen-ting;Huang Jie-ting;Zhao Duan;Jia Shan-shan;Wang Fang;Zhang Ting;Bai Yu-zuo;Wang Wei-lin;Yuan Zheng-wei
9 miR-351-3p Promotes Rat Amniotic Fluid-Derived Mesenchymal Stromal Cell Proliferation via Targeting the Coding Sequence of Abca4 期刊论文 Jieting Huang;Qi Zhao;Xiaowei Wei;Wei Ma;Wenting Luo;Hui Gu;Dan Liu;Yiwen He;Tianchu Huang;Yusi Liu;Chenfei Wang;Zhengwei Yuan
10 Intra-amniotic delivery of CRMP4 siRNA improves mesenchymal stem cell therapy in a rat spina bifida model 期刊论文 Xiaowei Wei;Songying Cao;Wei Ma;Chaonan Zhang;Hui Gu;Dan Liu;Wenting Luo;Yuzuo Bai;Weilin Wang;Zhengwei Yuan
11 Intra‐amniotic mesenchymal stem cell therapy improves the amniotic fluid microenvironment in rat spina bifida aperta fetuses 期刊论文 Xiaowei Wei;Wei Ma;Hui Gu;Dan Liu;Wenting Luo;Songying Cao;Shanshan Jia;Tianchu Huang;Yiwen He;Yuzuo Bai;Weilin Wang;Zhengwei Yuan
12 Neural Stem Cell-Derived Exosomal Netrin1 Contributes to Neuron Differentiation of Mesenchymal Stem Cells in Therapy of Spinal Bifida Aperta 期刊论文 Ling Ma;Xiaowei Wei;Wei Ma;Yusi Liu;Yanfu Wang;Yiwen He;Shanshan Jia;Yu Wang;Wenting Luo;Dan Liu;Tianchu Huang;Jiayu Yan;Hui Gu;Yuzuo Bai;Zhengwei Yuan
13 一种分子标志物及其制备生物标志物试剂的应用(专利) 专利 袁正伟;顾卉;安东;李慧;魏晓伟;刘丹
14 Candidate Circulating Biomarkers of Spontaneous Miscarriage After IVF-ET Identified via Coupling Machine Learning and Serum Lipidomics Profiling 期刊论文 Cai-xia Luan;Wei-dong Xie;Dan Liu;Wei Li;Zheng-wei Yuan
15 Complement factors and alpha-fetoprotein as biomarkers for noninvasive prenatal diagnosis of neural tube defects 期刊论文 Naixuan Dong;Hui Gu;Dan Liu;Xiaowei Wei;Wei Ma;Ling Ma;Yusi Liu;Yanfu Wang;Shanshan Jia;Jieting Huang;Chenfei Wang;Xuan He;Tianchu Huang;Yiwen He;Qiang Zhang;Dong An;Yuzuo Bai;Zhengwei Yuan
16 Influence of maternal obesity on the multi-omics profiles of the maternal body, gestational tissue, and offspring 期刊论文 Duan Zhao;Yusi Liu;Shanshan Jia;Yiwen He;Xiaowei Wei;Dan Liu;Wei Ma;Wenting Luo;Hui Gu;Zhengwei Yuan
17 神经管畸形发病机制研究进展与新策略 期刊论文 袁正伟
18 Transamniotic mesenchymal stem cell therapy for neural tube defects preserves neural function through lesion-specific engraftment and regeneration 期刊论文 Xiaowei Wei;Wei Ma;Hui Gu;Dan Liu;Wenting Luo;Yuzuo Bai;Weilin Wang;Vincent Chi Hang Lui;Peixin Yang;Zhengwei Yuan
19 Identification by RNA‐Seq of let‐7 clusters as prenatal biomarkers for nonsyndromic cleft lip with palate 期刊论文 Shanshan Jia;Qiang Zhang;Yu Wang;Xiaowei Wei;Hui Gu;Dan Liu;Wei Ma;Yiwen He;Wenting Luo;Zhengwei Yuan
20 一种与干细胞增殖相关的Abca4基因及其应用 专利 袁正伟;黄捷婷;顾卉;魏晓伟;马巍;刘丹;罗文婷
21 与唇腭裂产前无创诊断相关的miRNA分子标志物及其应用 专利 袁正伟;贾杉杉;顾卉;魏晓伟;马巍;刘丹;罗文婷
22 Automated prediction of early spontaneous miscarriage based on the analyzing ultrasonographic gestational sac imaging by the convolutional neural network: a case-control and cohort study 期刊论文 Yu Wang;Qixin Zhang;Chenghuan Yin;Lizhu Chen;Zeyu Yang;Shanshan Jia;Xue Sun;Yuzuo Bai;Fangfang Han;Zhengwei Yuan
23 Serum exosomal coronin 1A and dynamin 2 as neural tube defect biomarkers 期刊论文 Yanfu Wang;Ling Ma;Shanshan Jia;Dan Liu;Hui Gu;Xiaowei Wei;Wei Ma;Wenting Luo;Yuzuo Bai;Weilin Wang;Zhengwei Yuan
24 Amniotic fluid mesenchymal stromal cells from early stages of embryonic development have higher self-renewal potential 期刊论文 Jieting Huang;Wei Ma;Xiaowei Wei;Zhengwei Yuan
25 常见小儿先天畸形早期诊治关键技术与转化应用 奖励 袁正伟;任爱国;张霆;顾卉;魏晓伟;马巍;刘丹;陈骊珠;张赫楠;安东;杨中华
26 用于唇腭裂、神经管畸形和先天性心脏病胎儿产前无创诊断的分子标志物及其应用 专利 袁正伟;贾杉杉;顾卉;魏晓伟;马巍;刘丹;罗文婷
27 常见严重出生缺陷的早期诊断与治疗 奖励 袁正伟;顾卉;魏晓伟;马巍;刘丹;陈骊珠;安东;杨中华;张赫楠;薛佳;黄天楚
28 孕妇血清淀粉样P物质作为神经管缺陷产前标志物的研究 期刊论文 董乃萱;顾卉;刘丹;魏晓伟;马巍;马玲;袁正伟
29 Therapeutic potential of adenovirus-encoding brain-derived neurotrophic factor for spina bifida aperta by intra-amniotic delivery in a rat model 期刊论文 Wei Ma;Xiaowei Wei;Hui Gu;Dan Liu;Wenting Luo;Dong An;Yuzuo Bai;Zhengwei Yuan
30 Relationship between maternal heavy metal exposure and congenital heart defects: a systematic review and meta-analysis 期刊论文 Shimeng Li;Qinbo Wang;Wenting Luo;Shanshan Jia;Dan Liu;Wei Ma;Hui Gu;Xiaowei Wei;Yiwen He;Songying Cao;Zhengwei Yuan
31 用于神经管畸形、先天性心脏病和唇腭裂胎儿产前无创诊断的分子标志物及其应用 专利 袁正伟;王衍夫;马玲;王勤博
32 用于唇腭裂产前无创诊断的分子标志物及其应用 专利 袁正伟;贾杉杉;顾卉;魏晓伟;马巍;刘丹;罗文婷
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