基于HDACs调控的丙戊酸肝毒性机制及其生物标志物研究

81673510
2016
H3511.临床药理
肇丽梅
面上项目
教授
中国医科大学
54万元
组蛋白去乙酰化酶;生物标志物;脂质组学;丙戊酸;肝毒性
2017-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 丙戊酸单药治疗癫痫患儿导致肉碱缺乏的危险因素研究 期刊论文 马艺溢;陈亚南;赵明明;肇丽梅
2 核受体PXR和PPARA基因多态性对癫痫患者卡马西平血药浓度的影响 期刊论文 朱旭;陈亚南;路童;庞露;刘立民;肇丽梅
3 “痫康”癫痫自我管理APP的开发设计 奖励 中国医科大学附属盛京医院
4 Population pharmacokinetics of lamotrigine co-administered with valproic acid in Chinese epileptic children using nonlinear mixed effects modeling 期刊论文 Xu Shansen;Liu Limin;Chen Yanan;Liu Mei;Lu Tong;Wang Huanxin;Liu Shihao;Zhao Mingming;Zhao Limei
5 Emerging trends and knowledge structure of epilepsy during pregnancy research for 2000-2018: a bibliometric analysis 期刊论文 Wang Minglu;Li Weitao;Tao Yuying;Zhao Limei
6 Catalase C-262T Polymorphism Is a Risk Factor for Valproic Acid-Induced Abnormal Liver Function in Chinese Patients With Epilepsy 期刊论文 Ma Linfeng;Pan Yue;Sun Ming;Shen Haonan;Zhao Limei;Guo Yingjie
7 拉莫三嗪用于癫痫治疗的有效浓度范围评价 会议论文 王环鑫;王鸣璐;申红爽;赵曼;马艺溢;肇丽梅
8 基因组学与代谢组学技术在癫痫生物标志物中的研究现状 期刊论文 刘世浩;陈亚南;徐善森;肇丽梅
9 Development of a Simple and Rapid Method to Measure Free Fraction of Valproic Acid in Plasma Using Ultrafiltration and Ultra High Performance Liquid Chromatography-Mass Spectroscopy: Application to Therapeutic Drug Monitoring 期刊论文 Xu Shansen;Chen Yanan;Zhao Mingming;Zhao Limei
10 联合用药及年龄因素对丙戊酸蛋白结合参数的影响(英文) 会议论文 徐善森;陈亚南;赵明明;肇丽梅
11 Risk Factors for Valproic Acid-induced Hyperammonaemia in Chinese Paediatric Patients with Epilepsy 期刊论文 Xu Zhu;Xinlin Li;Ti Zhang;Limei Zhao
12 Involvement of CYP2E1-ROS-CD36/DGAT2 axis in the pathogenesis of VPA-induced hepatic steatosis in vivo and in vitro 期刊论文 Ma Linfeng;Wang Yani;Chen Xue;Zhao Limei;Guo Yingjie
13 Population pharmacokinetics of valproic acid in epileptic children: Effects of clinical and genetic factors 期刊论文 Xu Shansen;Chen Yanan;Zhao Mingming;Guo Yingjie;Wang Zhanyou;Zhao Limei
14 A Population Pharmacokinetic-pharmacogenetic Modelof Lamotrigine in Chinese Children with Epilepsy 会议论文 陈亚南;徐善森;王占友;赵明明;王环鑫;路童;肇丽梅
15 Associations of CYP2C9 and CYP2A6 Polymorphisms with the Concentrations of Valproate and its Hepatotoxin Metabolites and Valproate-Induced Hepatotoxicity 期刊论文 Zhao Mingming;Zhang Ti;Li Guofei;Qiu Feng;Sun Yaxin;Zhao Limei
16 拉莫三嗪在不同人群中群体药代动力学参数的系统评价 期刊论文 王鸣璐;李惟滔;陶玉瑛;肇丽梅
17 卡马西平在东北地区癫痫患者中的群体药代动力学模型建立与剂量选择 期刊论文 朱旭;秦元圆;路童;陈亚南;刘立民;肇丽梅
18 Association between the perturbation of bile acid homeostasis and valproic acid-induced hepatotoxicity. 期刊论文 Chen Yanan;Zhou Jingkai;Xu Shansen;Liu Mei;Wang Minglu;Ma Yiyi;Zhao Mingming;Wang Zhanyou;Guo Yingjie;Zhao Limei
19 Lipidomic Profiling Reveals Disruption of Lipid Metabolism in Valproic Acid-Induced Hepatotoxicity 期刊论文 Xu Shansen;Chen Yanan;Ma Yiyi;Liu Ting;Zhao Mingming;Wang Zhanyou;Zhao Limei
20 妊娠期抗癫痫药物的药代动力学变化及胎盘转运特征 期刊论文 陈亚南;刘立民;徐善森;肇丽梅
21 Cucurbitacin B suppresses proliferation of pancreatic cancer cells by ceRNA: Effect of miR-146b-5p and lncRNA-AFAP1-AS1 期刊论文 Zhou Jingkai;Liu Mei;Chen Yanan;Xu Shansen;Guo Yingjie;Zhao Limei
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