5-脂氧化酶通过调节γ-分泌酶活性促进β-淀粉样蛋白产生与沉积的机制研究

81200972
2012
H0912.神经退行性变及相关疾病
王涛
青年科学基金项目
讲师
中国医科大学
23万元
5-脂氧化酶;γ-分泌酶;阿尔茨海默病;β-淀粉样蛋白;转基因小鼠
2013-01-01到2015-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Ecdysterone protects gerbil brain from temporal global cerebral ischemia/reperfusion injury via preventing neuron apoptosis and deactivating astrocytes and microglia cells 期刊论文 Feng, Wan-Yu|Wang, Zhan-You|Cheng, Mao-Sheng|Wang, Yun-Jie|
2 5-脂氧化酶与阿尔茨海默病 期刊论文 徐盟|王涛|金莺|田伟|
3 The role of cyclooxygenase-2, interleukin-1beta and fibroblast growth factor-2 in the activation of matrix metalloproteinase-1 in sheared-chondrocytes and articular cartilage 期刊论文 Wang, Tao|Konstantopoulos, Konstantinos|Wang, Zhan-You|Wang, Pu|
4 By activating matrix metalloproteinase-7, shear stress promotes chondrosarcoma cell motility, invasion and lung colonization 期刊论文 Li, Jia-Yi|Konstantopoulos, Konstantinos|Wang, Zhan-You|Wang, Pu|
5 内质网应激反应与相关分子伴侣 期刊论文 徐盟|王涛|
6 Hypoxia-triggered m-calpain activation evokes endoplasmic reticulum stress and neuropathogenesis in a transgenic mouse model of Alzheimer's disease. 期刊论文 Wang, Xu|Zhao, Bao-Lu|An, Li|Wang, Zhan-You|
7 Trientine Reduces BACE1 Activity and Mitigates Amyloidosis via the AGE/RAGE/NF-kappaB Pathway in a Transgenic Mouse Model of Alzheimer's Disease 期刊论文 Wang, Xu|Zhao, Bao-Lu|An, Li|Wang, Zhan-You|
8 By activating matrix metalloproteinase-7, shear stress promotes chondrosarcoma cell motility, invasion and lung colonization 期刊论文 Li, Jia-Yi|Konstantopoulos, Konstantinos|Wang, Zhan-You|Wang, Pu|
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