基于PD-1/PD-L1通路的核心岩藻糖基化修饰调节细胞毒性T淋巴细胞杀伤非小细胞肺癌的作用机理研究

31870797
2018
C0506.糖、脂生物化学
李文哲
面上项目
教授
大连医科大学
59万元
程序性死亡受体1;肿瘤杀伤;N-糖基化修饰;功能效应;CTL活化
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Core Fucosylation Regulates the Function of Pre-BCR, BCR and IgG in Humoral Immunity 期刊论文 Yuhan Sun;Xueying Li;Tiantong Wang;Wenzhe Li
2 Core fucosylation of T cell receptor (TCR) promotes activation of CD4+ T cells through enhancing TCR-pMHC-II interaction in SLE 会议论文 李文哲
3 Effect of Taurine on Intestinal Microbiota and Immune Cells in Peyer’s Patches of Immunosuppressive Mice 期刊论文 H Fang;F Meng;F Piao;B Jin;M Li;W Li
4 High levels of fucosylation and sialylation of milk N‐glycans from mothers with gestational diabetes mellitus alter the offspring gut microbiome and immune balance in mice 期刊论文 Jiaorui Zhou;Yue Wang;Qingjie Fan;Yinhui Liu;He Liu;Jingyu Yan;Ming Li;Weijie Dong;Wenzhe Li
5 Core fucosylation of copper transporter 1 plays a crucial role in cisplatin‐resistance of epithelial ovarian cancer by regulating drug uptake 期刊论文 Xiaoxue Lv;Jiazhe Song;Kai Xue;Zhi Li;Ming Li;Danish Zahid;Hongyu Cao;Lu Wang;Wanli Song;Tonghui Ma;Jianguo Gu;Wenzhe Li
6 Core Fucosylation of Maternal Milk N-Glycan Evokes B Cell Activation by Selectively Promoting the l -Fucose Metabolism of Gut Bifidobacterium spp. and Lactobacillus spp 期刊论文 Ming Li;Yaqiang Bai;Jiaorui Zhou;Wei Huang;Jingyu Yan;Jia Tao;Qingjie Fan;Yang Liu;Di Mei;Qiulong Yan;Jieli Yuan;Patrice Malard;Zhongfu Wang;Jianguo Gu;Naoyuki Tanigchi;Wenzhe Li
7 Loss of core fucosylation enhances the anticancer activity of cytotoxic T lymphocytes by increasing PD‐1 degradation 期刊论文 Nianzhu Zhang;Ming Li;Xing Xu;Yingshu Zhang;Yancheng Liu;Meng Zhao;Peng Li;Jun Chen;Tomohiko Fukuda;Jianguo Gu;Xun Jin;Wenzhe Li
8 基于胶体金标记米曲霉素的免疫层析试纸法快速筛查SLE 期刊论文 赵丹青;李志;李明;王亚东;张晓辉;王若雨;李文哲
9 Core-fucosylation of maternal milk N-glycan regulates nonspecific humoral immune response of neonate through selectively promoting the L-fucose metabolism by gut Bifidobacterium and Lactobacillus spp. 会议论文 李文哲
10 米曲霉FleA基因的原核表达及纯化 期刊论文 孙钰涵;李志;王萌萌;李明;李文哲
11 Lactobacillus spp. create a protective micro-ecological environment through regulating the core fucosylation of vaginal epithelial cells against cervical cancer 期刊论文 Qingjie Fan;Yuanhang Wu;Mechou Li;Fan An;Lulu Yao;Meixian Wang;Xiuying Wang;Jieli Yuan;Kui Jiang;Wenzhe Li;Ming Li
12 T细胞受体的核心岩藻糖基化调节CD4+CD8+双阳性(DP)胸腺细胞增殖与分化 会议论文 李文哲
13 母乳核心岩藻糖基对新生儿肠道菌群及特异性体液免疫应答的调节作用 会议论文 李文哲
14 The significance of sialylation on the pathogenesis of Alzheimer’s disease 期刊论文 Kangkang Yang;Zhaofei Yang;Xiaofeng Chen;Wenzhe Li
15 Effect of taurine on thymus differentiation of Dex-induced immunosuppressive mice 期刊论文 J Piao;F Meng;H Fang;F Piao;B Jin;M Li;W Li
16 A novel immunochromatographic strips assay for rapid and simple detection of systemic lupus erythematosus 期刊论文 Yuhan Sun;Zhi Li;Wei Liang;Yanlong Zhang;Wanli Song;Jiazhe Song;Kai Xue;Meiling Wang;Wenying Sun;Jianguo Gu;Ming Li;Wenzhe Li
17 FoxO1 controls the expansion of pre-B cells by regulating the expression of interleukin 7 receptor α chain and its signal pathway 期刊论文 Zhi Li;Nianzhu Zhang;Fang Hui;Danish Zahid;Wei Zheng;Xuezhu Xu;Wenzhe Li
18 Core Fucosylation of Intestinal Epithelial Cells Protects Against Salmonella Typhi Infection via Up-Regulating the Biological Antagonism of Intestinal Microbiota 期刊论文 Sijia Hao;Qingjie Fan;Yaqiang Bai;Hui Fang;Jiaorui Zhou;Tomohiko Fukuda;Jianguo Gu;Ming Li;Wenzhe Li
19 Ablation of core fucosylation attenuates the signal transduction via T cell receptor to suppress the T cell development 期刊论文 Wei Liang;Shanshan Mao;Ming Li;Nianzhu Zhang;Shijie Sun;Hui Fang;Jianing Zhang;Jianguo Gu;Jingyu Wang;Wenzhe Li
20 Loss of core fucosylation in both ST6GAL1 and its substrate enhances glycoprotein sialylation in mice 期刊论文 Guoling Huang;Zhi Li;Yuqing Li;Gang Liu;Shijie Sun;Jianguo Gu;Akihiko Kameyama;Wenzhe Li;Weijie Dong
21 母乳蛋白核心岩藻糖基化有利于新生儿肠道双歧杆菌增长 期刊论文 刘洋;杨恬;白亚强;黄凤岚;李明;李文哲
22 Loss of core fucosylation enhances the anticancer activity of cytotoxic T lymphocytes by increasing PD-1 degradation 会议论文 李文哲
23 高核心岩藻糖基化母乳促进子代肠道双歧杆菌和乳杆菌的优势生长 期刊论文 梅迪;杨恬;白亚强;黄凤岚;孙永浩;梁明慧;郑雅云;董佳炎;姚正凯;李明;李文哲
24 Loss of core fucosylation suppressed the humoral immune response in Salmonella Typhimurium infected mice 期刊论文 Danish Zahid;Nianzhu Zhang;Hui Fang;Jianguo Gu;Ming Li;Wenzhe Li
25 一种核心岩藻糖基转移酶的抑制剂及其应用 专利 李文哲;张念竹;王文宇;李明;王若雨;李雪滢;丁宝龙
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