BMPR2突变导致肺动脉高压的表观调控机制及干预研究
81870050
2018
H0107.肺循环与肺血管疾病
王晓建
面上项目
研究员
中国医学科学院阜外医院
60万元
表观遗传;基因突变;肺动脉高压;骨形成蛋白受体2;DNA甲基化
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | 罕见病精准医疗:呼吁更多行动 | 期刊论文 | 王晓建 |
| 2 | Association of Rare PTGIS Variants With Susceptibility and Pulmonary Vascular Response in Patients With Idiopathic Pulmonary Arterial Hypertension | 期刊论文 | Xiao-Jian Wang;Xi-Qi Xu;Kai Sun;Ke-Qiang Liu;Su-Qi Li;Xin Jiang;Qin-Hua Zhao;Lan Wang;Fu-Hua Peng;Jue Ye;Zhi-Cheng Jing |
| 3 | NOTCH3 Mutations and CADASIL Phenotype in Pulmonary Arterial Hypertension Associated with Congenital Heart Disease | 期刊论文 | Rui Jiang;Kaisheng Lai;Jianping Xu;Xiang Feng;Shaoye Wang;Xiaojian Wang;Zhe Liu |
| 4 | 一种BMPR2基因突变大鼠的制备方法及应用 | 专利 | 荆志成;王晓建;李素琪;程春燕;吕子超;刘少飞;张思瑾;谭元卿;周玉平;刘倩倩 |
| 5 | 先心病合并肺动脉高压大鼠模型心脏重构趋势 | 期刊论文 | 潘慧;温彬;李天骐;马铭婕;叶梦婷;纪爽;潘湘斌;王晓建 |
| 6 | 国人肺动脉高压遗传特征及发病机制的探索与应用 | 奖励 | 荆志成;蒋鑫;徐希奇;王勇;刘岽;王晓建;颜艺;何阳阳;张锐;袁平;吴文汇;连天宇;吕子超;张思瑾;孙凯 |
| 7 | 一例儿童肺动脉高压的遗传检测与咨询 | 期刊论文 | 吴艳;潘慧;叶梦婷;马铭婕;张学佳;惠汝太;杨伟宪;华潞;王晓建 |
| 8 | 改良型先天性心脏病相关肺动脉高压动物模型的建立 | 期刊论文 | 叶梦婷;潘慧;温彬;马铭婕;李天骐;纪爽;王晓建;杨晓敏 |
| 9 | EphA4 is highly expressed in the atria of heart and its deletion leads to atrial hypertrophy and electrocardiographic abnormalities in rats | 期刊论文 | Jingwen Li;Wei Dong;Xiang Gao;Wei Chen;Caixian Sun;Jing Li;Shan Gao;Yaxin Zhang;Jiayue He;Dan Lu;Rui Jiang;Mingjie Ma;Xiaojian Wang;Lianfeng Zhang |
| 10 | Angiopoietin 2 as a Novel Potential Biomarker for Acute Aortic Dissection | 期刊论文 | Bi Huang;Li Tian;Zhaoran Chen;Liang Zhang;Wenjun Su;Tianyi Lu;Yanmin Yang;Rutai Hui;Xiaojian Wang;Xiaohan Fan |
| 11 | Text Mining-Based Drug Discovery for Connective Tissue Disease–Associated Pulmonary Arterial Hypertension | 期刊论文 | Jiang-Shan Tan;Song Hu;Ting-Ting Guo;Lu Hua;Xiao-Jian Wang |
| 12 | 一种自发性肺动脉高压模型的建立及应用 | 专利 | 王晓建;吴艳;潘湘斌;李天骐;潘慧;马铭婕;张学佳;吕婷婷 |
| 13 | The features of rare pathogenic BMPR2 variants in pulmonary arterial hypertension: Comparison between patients and reference population | 期刊论文 | Zi-Chao Lyu;Lan Wang;Jian-Hui Lin;Su-Qi Li;Dan-Chen Wu;Tian-Yu Lian;Shao-Fei Liu;Jue Ye;Xin Jiang;Xiao-Jian Wang;Zhi-Cheng Jing |
| 14 | Integrin α9 is involved in the pathopoiesis of acute aortic dissection via mediating phenotype switch of vascular smooth muscle cell | 期刊论文 | Bi Huang;Yuting Niu;Zhaoran Chen;Yanmin Yang;Xiaojian Wang |
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