基于骨架迁越的肽嗪类极光激酶A和VEGFR-2双靶点抑制剂的合成及生物活性的研究

21672093
2016
B0706.药物化学生物学
陈世武
面上项目
教授
兰州大学
65万元
抗肿瘤活性;表皮增长因子受体2;激酶抑制剂;极光激酶
2017-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 一种4-胺取代酞嗪酮极光激酶B抑制剂及其制备与应用 专利 陈世武;张秀娟
2 Discovery of novel 2,4-disubstituted pyrimidines as Aurora kinase inhibitors 期刊论文 Yu Xu;Shu-Yi Hao;Xiu-Juan Zhang;Wen-Bo Li;Xue-Peng Qiao;Zi-Xiao Wang;Shi-Wu Chen
3 Synthesis and identification of 2,4-bisanilinopyrimidines bearing 2,2,6,6-tetramethylpiperidine-N-oxyl as potential Aurora A inhibitors 期刊论文 Chun-Yan Sang;Wen-Wen Qin;Xiu-Juan Zhang;Yu Xu;You-Zhen Ma;Xing-Rong Wang;Ling Hui;Shi-Wu Chen
4 一种肽嗪酮化合物及其制备与应用 专利 陈世武;王维
5 一种3,5-二取代的二氨基吡嗪化合物及其制备工艺与应用 专利 陈世武;孛永鑫
6 Novel conjugates of podophyllotoxin and coumarin: Synthesis, cytotoxicities, cell cycle arrest, binding CT DNA and inhibition of Topo II beta 期刊论文 Shu-Yi Hao;Shi-Liang Feng;Xing-Rong Wang;Zhichao Wang;Shi-Wu Chen;Ling Hui
7 Synthesis and bioevaluation of N-(3,4,5-trimethoxyphenyl)-1H- pyrazolo[3,4-b]pyridin-3-amines as tubulin polymerization inhibitors with anti-angiogenic effects 期刊论文 Shu-Yi Hao;Zhi-Yuan Qi;Shuai Wang;Xing-Rong Wang;Shi-Wu Chen
8 2-(4-(3-amino-1H-indazol-6-yl)-1H-pyrazol-1-yl)-N-phenyl acetamide derivatives as vascular endothelial growth factor receptor-2 inhibitors 会议论文 Xing-Rong Wang;Shi-Wu Chen
9 一种1H-吲唑VEGFR-2激酶抑制剂及其制备与应用 专利 陈世武;王兴荣
10 Synthesis, biological evaluation and molecular modeling study of 2-amino-3,5-disubstituted-pyrazines as Aurora kinases inhibitors 期刊论文 Yong-Xin Bo;Rong Xiang;Yu Xu;Shu-Yi Hao;Xing-Rong Wang;Shi-Wu Chen
11 Synthesis and biological evaluation of 4 beta-(thiazol-2-yl)amino-4'-O-demethyl-4-deoxypodophyllotoxins as topoisomerase-II inhibitors 期刊论文 Chun-Yan Sang;Heng-Zhi Tian;Yue Chen;Jian-Fei Liu;Shi-Wu Chen;Ling Hui
12 Synthesis and biological evaluation of 2,4-disubstituted phthalazinones as Aurora kinase inhibitors 期刊论文 Wei Wang;Xiu Feng;Huan-Xiang Liu;Shi-Wu Chen;Ling Hui
13 The synthesis and anti‐tumour properties of novel 4-substituted phthalazinones as Aurora B kinase inhibitors 期刊论文 Xiu-Juan Zhang;Yu Xu;Hong-Xia Mou;Shuai Wang;Shu-Yi Hao;Shi-Wu Chen
14 Synthesis and antioxidant activity of conjugates of hydroxytyrosol and coumarin 期刊论文 Wen-Bo Li;Xue-Peng Qiao;Zi-Xiao Wang;Shuai Wang;Shi-Wu Chen
15 Synthesis and biological evaluation of nitroxide labeled pyrimidines as Aurora kinase inhibitors 期刊论文 You-Zhen Ma;Zhen-Bo Tang;Chun-Yan Sang;Zhi-Yuan Qi;Ling Hui;Shi-Wu chen
16 Synthesis and biological evaluation of 1-(benzofuran-3-yl)-4-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole derivatives as tubulin polymerization inhibitors 期刊论文 Zhi-Yuan Qi;Shu-Yi Hao;Heng-Zhi Tian;Hong-Li Bian;Ling Hui;Shi-Wu Chen
17 Design, synthesis and biological evaluation of indole-2-one derivatives as potent BRD4 inhibitors 期刊论文 Yu Xu;Xiu-Juan Zhang;Wen-Bo Li;Xing-Rong Wang;Shuai Wang;Xue-Peng Qiao;Shi-Wu Chen
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