基于转运体OATs和肾脱氢肽酶双靶点缓解亚胺培南肾毒性的药代动力学研究

81903706
2019
H3510.药物代谢与药物动力学
霍晓奎
青年科学基金项目
副研究员
大连医科大学
21万元
肾毒性;有机阴离子转运体;中药;亚胺培南;脱氢肽酶
2020-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 JBP485, A Dual Inhibitor of Organic Anion Transporters (OATs) and Renal Dehydropeptidase-I (DHP-I), Protects Against Imipenem-Induced Nephrotoxicity 期刊论文 Chong Wang;Changyuan Wang;Jingjing Wu;Qiang Meng;Huan Jin;Huijun Sun;Taiichi Kaku;Jing Chen;Xiaokui Huo;Kexin Liu
2 Targeting renal OATs to develop renal protective agent from traditional Chinese medicines: Protective effect of Apigenin against Imipenem-induced nephrotoxicity 期刊论文 Huo Xiaokui;Meng Qiang;Wang Changyuan;Wu Jingjing;Zhu Yanna;Sun Pengyuan;Ma Xiaodong;Sun Huijun;Liu Kexin
3 UGTs-mediated metabolic interactions contribute to enhanced anti-inflammation activity of Jinhongtang 期刊论文 Fan Wu;Yan Wang;Quanxi Mei;Qinhua Chen;Chengpeng Sun;Xia Lv;Lei Feng;Chao Wang;Yanyan Zhang;Bangjiang Fang;Xiaokui Huo;Xiangge Tian;Xiaochi Ma
4 Simultaneous Determination of Ten Active Components From Jinhongtang Granule in Rat Plasma by LC–MS/MS and its Application to a Comparative Pharmacokinetic Study in Normal and Sepsis Rats In Vivo and In Vitro 期刊论文 Fan Wu;Baojing Zhang;Yu Zhang;Ting Zhao;Yan Wang;Xiangge Tian;Chengpeng Sun;Bangjiang Fang;Xiaokui Huo;Xiaochi Ma
5 Protective effect of cilastatin against diclofenac-induced nephrotoxicity through interaction with diclofenac acyl glucuronide via organic anion transporters 期刊论文 Huo Xiaokui;Meng Qiang;Wang Changyuan;Wu Jingjing;Wang Chong;Zhu Yanna;Ma Xiaodong;Sun Huijun;Liu Kexin
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