Bcl-2家族蛋白共价抑制剂——基于结构的分子设计和共价修饰“弹头”的筛选
81903462
2019
H3401.合成药物化学
王紫千
青年科学基金项目
副教授
大连理工大学
20万元
共价抑制剂;基于结构的分子设计;共价修饰“弹头”;Bcl-2家族蛋白
2020-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
查看更多信息请先登录或注册
查看更多信息请先登录或注册
查看更多信息请先登录或注册
| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Ectopic BH3-only protein Bim acts as a cochaperone to positively regulate Hsp70 in yeast | 期刊论文 | Pan Hao;Song Ting;Wang Ziqian;Guo Yafei;Zhang Hong;Ji Tong;Cao Keke;Zhang Zhichao |
| 2 | The chaperone Hsp70 is a BH3 receptor activated by the pro-apoptotic Bim to stabilize anti-apoptotic clients | 期刊论文 | Guo Zongwei;Song Ting;Wang Ziqian;Lin Donghai;Cao Keke;Liu Peng;Feng Yingang;Zhang Xiaodong;Wang Peiran;Yin Fangkui;Dai Jian;Zhou Sheng;Zhang Zhichao |
| 3 | A "Three-in-One" Multifunctional Probe for Bcl-2/Mcl-1 Profiling and Visualizingin Situ | 期刊论文 | Zhang Xiaodong;Wang Ziqian;Guo Zongwei;Song Ting;He Nianzhe;Zhu Junjie;Cao Keke;Zhang Zhichao |
| 4 | Targeting the Allosteric Pathway That Interconnects the Core- Functional Scaffold and the Distal Phosphorylation Sites for Specific Dephosphorylation of Bcl-2 | 期刊论文 | Wang Ziqian;Song Ting;Guo Zongwei;Cao Keke;Chen Chao;Feng Yingang;Wang Hang;Yin Fangkui;Zhou Sheng;Dai Jian;Zhang Zhichao |
| 5 | 4-取代萘酰亚胺类化合物及其应用 | 专利 | 张志超;王紫千;宋婷 |
| 6 | Bim transfer between Bcl-2-like protein and Hsp70 underlines Bcl-2/Hsp70 crosstalk to regulate apoptosis | 期刊论文 | Zhang Hong;Guo Zongwei;Guo Yafei;Wang Ziqian;Tang Yao;Song Ting;Zhang Zhichao |
| 7 | Structure-based design, synthesis, and evaluation of Bcl-2/Mcl-1 dual inhibitors | 期刊论文 | Zhu Junjie;Wang Ziqian;Guo Zongwei;Zhang Xiaodong;Song Ting;Guo Yafei;Ji Tong;Zhang Zhichao |
| 8 | Discovery of a Fluorogenic Probe for In Situ Pyruvate Kinase M2 Isoform (PKM2) Labeling through Chemoselective SNAr with a Binding Site Lysine Residue | 期刊论文 | Wang Ziqian;Zhang Xiaodong;Zhang Hong;Tang Yao;Pan Hao;Wang Hang;Ji Tong;Guo Yafei;Gao Qishuang;Song Ting;Zhang Zhichao |
| 9 | A novel Hsp70 inhibitor specifically targeting the cancer-related Hsp70-Bim protein-protein interaction | 期刊论文 | Wang Ziqian;Song Ting;Guo Zongwei;Uwituze Laura B.;Guo Yafei;Zhang Hong;Wang Hang;Zhang Xiaodong;Pan Hao;Ji Tong;Yin Fangkui;Zhou Sheng;Dai Jian;Zhang Zhichao |
| 10 | Small-molecule inhibitor targeting the Hsp70-Bim protein-protein interaction in CML cells overcomes BCR-ABL-independent TKI resistance | 期刊论文 | Song Ting;Guo Yafei;Xue Zuguang;Guo Zongwei;Wang Ziqian;Lin Donghai;Zhang Hong;Pan Hao;Zhang Xiaodong;Yin Fangkui;Wang Hang;Uwituze Laura Bonnette;Zhang Zhichao |
| 11 | 2-氰基非那烯酮类化合物及其在白血病治疗中的应用 | 专利 | 张志超;王紫千;宋婷 |
| 12 | Bcr-Abl drives the formation of Hsp70/Bim PPI to stabilize oncogenic clients and prevent cells from undergoing apoptosis | 期刊论文 | Hong Zhang;Ting Song;Ziqian Wang;Uwituze Laura Bonnette;Yafei Guo;Hang Wang;Qishuang Gao;Zhichao Zhang |
查看更多信息请先登录或注册
