核磁共振研究金属药物的细胞摄取与转运的分子机制

U1332210
2013
A3205.稳态强磁场
刘扬中
联合基金项目
教授
中国科学技术大学
300万元
蛋白质;铂;核磁共振;机理;金属药物
2014-01-01到2017-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 The ligation of aspirin to cisplatin demonstrates significant synergistic effects on tumor cells 期刊论文 Cheng Qinqin;Shi Hongdong;Wang Hongxia;Min Yuanzeng;Wang Jun;Liu Yangzhong
2 Rational Design of Polyion Complex Nanoparticles to Overcome Cisplatin Resistance in Cancer Therapy 期刊论文 Yang Xian-Zhu; Du Xiao-Jiao; Liu Yang; Zhu Yan-Hua; Liu Yang-Zhong; Li Ya-Ping; Wang Jun
3 The Reaction of Arsenite with Proteins Relies on Solution Conditions 期刊论文 Zhao Linhong; Wang Zhen; Xi Zhaoyong; Xu Dechen; Chen Siming; Liu Yangzhong
4 A comparative study on the interactions of human copper chaperone Cox17 with anticancer organoruthenium(II) complexes and cisplatin by mass spectrometry 期刊论文 Li Lijie;Guo Wei;Wu Kui;Wu Xuelei;Zhao Linhong;Zhao Yao;Luo Qun;Wang Yuanyuan;Liu Yangzhong;Zhang Qingwu;Wang Fuyi
5 Glutathione selectively modulates the binding of platinum drugs to human copper chaperone Cox17. 期刊论文 Zhao Linhong;Wang Zhen;Wu Han;Xi Zhaoyong;Liu Yangzhong
6 Platinum transfer from hCTR1 to Atox1 is dependent on the type of platinum complex 期刊论文 Wu Xuelei;Yuan Siming;Wang Erqiong;Tong Yang;Ma Guolin;Wei Kaiju;Liu Yangzhong
7 Proteins in the Mechanism of Platinum Antitumor Drugs 会议论文 Dechen Xu;Zhaoyong Xi;Linhong Zhao;Siming Chen;Yangzhong Liu
8 Human Serum Albumin Conjugated Nanoparticles for pH and Redox-Responsive Delivery of a Prodrug of Cisplatin. 期刊论文 Shi Hongdong;Cheng Qinqin;Yuan Siming;Ding Xin;Liu Yangzhong
9 A cell-penetrating protein designed for bimodal fluorescence and magnetic resonance imaging 期刊论文 Wu Qin;Cheng Qinqin;Yuan Siming;Qian Junchao;Zhong Kai;Qian Yinfeng;Liu Yangzhong
10 A dual-fluorescent nano-carrier for delivering photoactive ruthenium polypyridyl complexes 期刊论文 Shi Hongdong;Fang Tiantian;Tian Yao;Huang Hai;Liu Yangzhong
11 Copper binding promotes the interaction of cisplatin with human copper chaperone Atox1 期刊论文 Xi Zhaoyong;Guo Wei;Tian Changlin;Wang Fuyi;Liu Yangzhong
12 一种融合蛋白及其制备方法 专利 吴芩;刘扬中
13 The Design and Nano-delivery of Anticancer Platinum(IV) Prodrugs 会议论文 Hongdong Shi;Qinqin Cheng;Yuanzeng Min;Yangzhong Liu
14 Protein-protein interaction analysis in crude bacterial lysates using combinational method of F-19 site-specific incorporation and F-19 NMR 期刊论文 Li Dong;Zhang Yanan;He Yao;Zhang Chengwei;Wang Jiefei;Xiong Ying;Zhang Longhua;Liu Yangzhong;Shi Pan;Tian Changlin
15 Platinum Anticancer Drugs: the Mechanistic Study and New Drug Design 会议论文 Yangzhong Liu
16 Cisplatin binds to human copper chaperone Cox17: the mechanistic implication of drug delivery to mitochondria 期刊论文 Zhao Linhong;Cheng Qinqin;Wang Zhen;Xi Zhaoyong;Xu Dechen;Liu Yangzhong
17 Asplatin enhances drug efficacy by altering the cellular response 期刊论文 Cheng Qinqin;Shi Hongdong;Wang Hongxia;Wang Jun;Liu Yangzhong
18 Proteins in the Mechanism of Metallodrugs 会议论文 Yangzhong Liu
19 Cisplatin Preferentially Binds to Zinc Finger Proteins Containing C3H1 or C4 Motifs 期刊论文 Yuan Siming;Ding Xin;Cui Yang;Wei Kaiju;Zheng Yuchuan;Liu Yangzhong
20 Effects of Buffers and pH on the Reaction of a trans-Platinum Complex with 5-Guanosine Monophosphate 期刊论文 Li Chan;Ding Yi;Cheng Lanjun;Zheng Yuchuan;Sletten Einar;Liu Yangzhong
21 Binding States of Protein-Metal Complexes in Cells 期刊论文 Li Gongyu;Yuan Siming;Pan Yang;Liu Yangzhong;Huang Guangming
22 铂类配合物、由该铂类化合物制得的蛋白质复合物及其制备方法 专利 王震;刘扬中;师红东;程芹芹;张文星
23 Multifunctional platinum-based nanoparticles for biomedical applications 期刊论文 Cheng Qinqin;Liu Yangzhong
24 铜转运蛋白C端金属结合域与Ag+及Hg2+的相互作用 期刊论文 朱云城;王二琼;马国林;康彦彪;赵林泓;刘扬中
25 一种靶向肽修饰的金纳米颗粒及其制备方法和其作为四价铂前体药物载体的应用 专利 刘蕾;刘扬中
26 The Effect of Salts in Promoting Specific and Competitive Interactions between Zinc Finger Proteins and Metals 期刊论文 Gongyu Li;Siming Yuan;Shihui Zheng;Yuting Chen;Zhen Zheng;Yangzhong Liu;Guangming Huang
27 Conserved residues that modulate protein trans-splicing of Npu DnaE split intein 期刊论文 Wu Qin; Gao Zengqiang; Wei Yong; Ma Guolin; Zheng Yuchuan; Dong Yuhui; Liu Yangzhong
28 A Versatile pH‐Responsive Platformfor Intracellular Protein Delivery Using Calcium Phosphate Nanoparticles 期刊论文 Bingru Zeng;Hongdong Shi;Yangzhong Liu
29 Protein Interaction of Platinum Anticancer Drugs 会议论文 Yangzhong Liu
30 Platinum Antitumor Drugs: Mechanistic Studies and New Drug Design. 会议论文 Qinqin Cheng;Hongdong Shi;Zhaoyong Xi;Linhong Zhao;Siming Chen;Yangzhong Liu
31 Co-delivery of all-trans-retinoic acid enhances the anti-metastasis effect of albumin-bound paclitaxel nanoparticles 期刊论文 Huang Hai;Shi Hongdong;Liu Jing;Min Yuanzeng;Wang Yucai;Wang Andrew Z.;Wang Jun;Liu Yangzhong
32 紫杉醇与全反式维甲酸共运输白蛋白纳米药物 专利 黄海;刘扬中
33 顺铂耐药的分子机制 期刊论文 郗照勇;刘扬中
34 NMR Investigation of Proteins in the Mechanism of Platinum Antitumor Drugs 会议论文 Linhong Zhao;Siming Chen;Dechen Xu;Zhaoyong Xi;Yangzhong Liu
35 Copper binding modulates the platination of human copper chaperone Atox1 by antitumor trans-platinum complexes 期刊论文 Xi Zhaoyong;Guo Wei;Tian Changlin;Wang Fuyi;Liu Yangzhong
36 Proteins in the Mechanism of Platinum AnticancerDrugs 会议论文 Yangzhong Liu
37 The reaction of a platinated methionine motif of CTR1 with cysteine and histidine is dependent upon the type of precursor platinum complex. 期刊论文 Ma Guolin;Wu Qin;Wu Xuelei;Arnesano Fabio;Natile Giovanni;Sletten Einar;Liu Yangzhong
38 Nano-size Uni-lamellar Lipodisq Improved In situ Auto-phosphorylation Analysis of E. coli Tyrosine Kinase using 19F Nuclear Magnetic Resonance 期刊论文 Dong Li;Juan Li;Yonglong Zhuang;Longhua Zhang;Ying Xiong;Pan Shi;Changlin Tian
39 Oral delivery of a platinum anticancer drug using lipid assisted polymeric nanoparticles. 期刊论文 Cheng Qinqin;Shi Hongdong;Huang Hai;Cao Zhiting;Wang Jun;Liu Yangzhong
40 铂类抗肿瘤药物与蛋白质的作用机理 期刊论文 房田田;曹开明;程岚军;赵林泓;刘扬中
41 Transporting Platinum Drugs from Copper Chaperone to ATPase: the Mechanistic Implication of Drug Efflux Mediated Cisplatin Resistance. 期刊论文 Dechen Xu;Zhaoyong Xi;Linhong Zhao;Yangzhong Liu
42 Copper-finger protein of Sp1: the molecular basis of copper sensing 期刊论文 Yuan Siming;Chen Siming;Xi Zhaoyong;Liu Yangzhong
43 Deciphering of interactions between platinated DNA and HMGB1 by hydrogen/deuterium exchange mass spectrometry 期刊论文 Wang Yuanyuan;Du Zhifeng;Zheng Wei;Wu Kui;Xu Decheng;Luo Qun;Zhao Yao;Han Juanjuan;Liu Yangzhong;Wang Fuyi
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