氟西汀通过5-HT系统多靶点对抗AD病理过程的作用和机制
81671259
2016
H0912.神经退行性变及相关疾病
唐勇
面上项目
教授
重庆医科大学
52万元
突触;氟西汀;神经元;转基因AD小鼠;髓鞘
2017-01-01到2020-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Fluoxetine attenuates the impairment of spatial learning ability and prevents neuron loss in middle-aged APPswe/PSEN1dE9 double transgenic Alzheimer's disease mice | 期刊论文 | Ma Jing;Gao Yuan;Jiang Lin;Chao Feng-lei;Huang Wei;Zhou Chun-ni;Tang Wei;Zhang Lei;Huang Chun-xia;Zhang Yi;Luo Yan-min;Xiao Qian;Yu Hua-rong;Jiang Rong;Tang Yong |
| 2 | Exercise prevents cognitive function decline and demyelination in the white matter of APP/PS1 transgenic AD mice | 期刊论文 | Lei Zhang;Feng-lei Chao;Yan-min Luo;Qian Xiao;Lin Jiang;Chun-ni Zhou;Yi Zhang;Fu-lin Lv;Qi He;Jing Ma;Yong Tang |
| 3 | 氟西汀通过增加阿尔茨海默病APP/PS1转基因小鼠脑内乙酰胆碱的含量改善其空间学习能力 | 期刊论文 | 黄维;马晶;晁凤蕾;张蕾;唐炜;李常琼;李桃;赵振华;张毅;周春妮;蒋林;唐勇 |
| 4 | Anti-Lingo-1 antibody ameliorates spatial memory and synapse loss induced by chronic stress | 期刊论文 | Yu-Han Xie;Chun-Ni Zhou;Xin Liang;Jing Tang;Chun-Mao Yang;Yan-Min Luo;Feng-Lei Chao;Lin Jiang;Jin Wang;Ying-Qiang Qi;Pei-Lin Zhu;Yue Li;Kai Xiao;Yong Tang |
| 5 | Protective effects of 17β-estradiol on hippocampal myelinated fibers in ovariectomized middle-aged rats | 期刊论文 | Qian Xiao;Yanmin Luo;Fulin Lv;Qi He;Hong Wu;Fenglei Chao;Xuan Qiu;Lei Zhang;Yuan Gao;Chunxia Huang;Sanrong Wang;Chunni Zhou;Yi Zhang;Lin Jiang;Yong Tang |
| 6 | 早期APP/PS1转基因AD模型小鼠海马胆碱能神经元改变的体视学研究 | 期刊论文 | 李常琼;晁凤蕾;张蕾;唐静;蒋林;张毅;周春妮;黄维;唐炜;李桃;赵振华;唐勇;吴宏 |
| 7 | Astrocytes induce proliferation of oligodendrocyte progenitor cells via connexin 47-mediated activation of Chi3l1 expression | 期刊论文 | Lu Jiang;Dan Xu;Wen-jin Zhang;Yong Tang;Yan Peng |
| 8 | Fluoxetine promotes hippocampal oligodendrocyte maturation and delays learning and memory decline in APP/PS1 mice | 期刊论文 | Fenglei Chao;Yi Zhang;Lei Zhang;Lin Jiang;Chunni Zhou;Jing Tang;Xin Liang;Jinhua Fan;Xiaoyun Dou;Yong Tang |
| 9 | Stereological study on the positive effect of running exercise on the capillaries in the hippocampus in a depression model | 期刊论文 | Lin-mu Chen;Chun-ni Zhou;Chuan-xue Tan;Fei-fei Wang;Yuan Gao;Chun-xia Huang;Yi Zhang;Lin Jiang;Yong Tang |
| 10 | Anti-LINGO-1 antibody treatment improves chronic stress-induced spatial memory impairments and oligodendrocyte loss in the hippocampus | 期刊论文 | Chunmao Yang;Jing Tang;Xin Liang;Yingqiang Qi;Yanmin Luo;Yuhan Xie;Jin Wang;Lin Jiang;Chunni Zhou;Chunxia Huang;Yong Tang |
| 11 | 抑郁症易感性差异与海马CA3区及DG内树突棘数量变化的相关性研究 | 期刊论文 | 蒋艳红;王瑾;胡梦兰;罗艳敏;高原;梁芯;肖倩;周春妮;晁凤蕾;张蕾;唐静;黄春霞;唐勇 |
| 12 | Effects of fluoxetine on the neurons in the medial prefrontal cortex of early APP/PS1 transgenic mice | 会议论文 | Lin Jiang;Chun-ni Zhou;Yi Zhang;Jing Ma;Lei Zhang;Feng-lei Chao;Yan-min Luo;Wei Huang;Yong-xin Wu;Jin-hua Fan;Yong Tang |
| 13 | Stereological investigation of the effects of treadmill running exercise on the hippocampal neurons in middle-aged APP/PS1 transgenic mice | 期刊论文 | Feng-lei Chao;Lin Jiang;Yi Zhang;Chun-ni Zhou;Lei Zhang;Jing Tang;Xin Liang;Ying-qiang Qi;Yan-qing Zhu;Jing Ma;Yong Tang |
| 14 | 抗Lingo-1抗体对抑郁症伴认知障碍大鼠海马DG区少突胶质细胞作用的研究 | 期刊论文 | 杨春茂;唐静;梁芯;綦英强;张钐钐;吴永鑫;范金花;罗艳敏;蒋林;周春妮;张毅;黄春霞;晁凤蕾;高原;张蕾;唐勇 |
| 15 | 雌激素对大脑白质结构影响的研究进展 | 期刊论文 | 罗艳敏;肖倩;何琦;晁凤蕾;张蕾;唐勇 |
| 16 | The effects of fluoxetine on oligodendrocytes in the hippocampus of chronic unpredictable stress-induced depressed model rats | 期刊论文 | Jin Wang;Yanmin Luo;Jing Tang;Xin Liang;Chunxia Huang;Yuan Gao;Yingqiang Qi;Chunmao Yang;FengLei Chao;Yang Zhang;Yong Tang |
| 17 | Effects of exercise on capillaries in the white matter of transgenic AD mice | 期刊论文 | Yi Zhang;Feng-lei Chao;Chun-ni Zhou;Lin Jiang;Lei Zhang;Lin-mu Chen;Yan-min Luo;Qian Xiao;Yong Tang |
| 18 | Fluoxetine protects the cognitive function and the hippocampus in early age of APP/PS1 transgenic AD mouse | 会议论文 | Chun-ni Zhou;Yi Zhang;Lin Jiang;Feng-lei Chao;Lei Zhang;Jing Ma;Yan-min Luo;Qian Xiao;Yong Tang |
| 19 | Stimulated left DLPFC-nucleus accumbens functional connectivity predicts the anti-depression and anti-anxiety effects of rTMS for depression | 期刊论文 | Lian Du;Huan Liu;Wan-yi Du;Feng-lei Chao;Lei Zhang;Ke-jian Wang;Chun-xia Huang;Yuan Gao;Yong Tang |
| 20 | 雌激素替代治疗对中年卵巢切除大鼠大脑白质、海马内髓鞘及Lingo-1蛋白的影响 | 期刊论文 | 李桃;罗艳敏;肖倩;綦英强;晁凤蕾;黄维;唐勇 |
| 21 | Sex differences in the white matter and myelinated fibers of APP/PS1 mice and the effects of running exercise on the sex differences of AD mice | 期刊论文 | Chun-ni Zhou;Feng-lei Chao;Yi Zhang;Lin Jiang;Lei Zhang;Yan-min Luo;Qian Xiao;Lin-mu Chen;Yong Tang |
| 22 | Four-month treadmill exercise prevents the decline in spatial learning and memory abilities and the loss of spinophilin- immunoreactive puncta in the hippocampus of APP/PS1 transgenic mice | 期刊论文 | Lei Zhang;Wei Tang;Feng-lei Chao;Chun-ni Zhou;Lin Jiang;Yi Zhang;Xin Liang;Jing Tang;Ying-qiang Qi;Hao Yang;Qi He;Shan-shan Zhang;Lin Zhu;Yan Peng;Yong Tang |
| 23 | Exercise protects myelinated fibers of white matter in a rat model of depression. | 期刊论文 | Qian Xiao;Fei-fei Wang;Yan-min Luo;Lin-mu Chen;Feng-lei Chao;Chuan-xue Tan;Yuan Gao;Chun-xia Huang;Lei Zhang;Xin Liang;Jing Tang;Ying-qiang Qi;Lin Jiang;Yi Zhang;Chun-ni Zhou;Yong Tang |
| 24 | 氟西汀对8月龄APP/PS1小鼠海马齿状回内胆碱能神经元作用的体视学研究 | 期刊论文 | 吴永鑫;周春妮;范金花;蒋林;张毅;张蕾;晁凤蕾;马晶;梁芯;綦英强;唐静;杨春茂;唐勇 |
| 25 | 跑步锻炼减少中老年APP/PS1双转基因AD小鼠海马齿状回内树突棘丢失 | 期刊论文 | 唐炜;晁凤蕾;蒋林;张毅;周春妮;张蕾;梁芯;朱殷青;黄维;李常琼;李桃;赵振华;唐勇 |
| 26 | Long-term running exercise delays age-related changes in white matter in rats | 期刊论文 | Lin Chen;Feng-Lei Chao;Wei Lu;Lei Zhang;Chun-Xia Huang;Shu Yang;Xuan Qiu;Hao Yang;Yuan-Yu Zhao;San-Rong Wang;Chen Li;Yong Tang |
| 27 | Effects of estrogen replacement therapy on the myelin sheath ultrastructure of myelinated fibers in the white matter of middle-aged ovariectomized rats | 期刊论文 | Qi He;Yan-min Luo;Fu-lin Lv;Qian Xiao;Feng-lei Chao;Xuan Qiu;Lei Zhang;Yuan Gao;Yun Xiu;Chun-xia Huang;Yong Tang |
| 28 | Exercise-induced nitric oxide contributes to spatial memory and hippocampal capillaries in rats | 期刊论文 | Yingqiang Qi;Sanrong Wang;Yanmin Luo;Wei Huang;Linmu Chen;Yi Zhang;Xin Liang;Jing Tang;Yang Zhang;Lei Zhang;Fenglei Chao;Yuan Gao;Yanqing Zhu;Yong Tang |
| 29 | Quantitative study of the capillaries within the white matter of the Tg2576 mouse model of Alzheimer's disease | 期刊论文 | Yi Zhang;Feng-lei Chao;Lei Zhang;Lin Jiang;Chun-ni Zhou;Lin-mu Chen;Wei Lu;Rong Jiang;Yong Tang |
| 30 | 阿尔兹海默病的血管病变研究进展 | 期刊论文 | 张毅;晁凤蕾;张蕾;蒋林;周春妮;唐勇 |
| 31 | APP/PS1转基因小鼠海马内少突胶质细胞变化的体视学研究 | 期刊论文 | 吴燕丽;张毅;晁凤蕾;蒋林;周春妮;杨浩;唐勇 |
| 32 | 星形胶质细胞调控少突胶质前体细胞增殖机制研究 | 期刊论文 | 刘兆雨;王尚;徐丹;高晓燕;姜露;唐勇;彭彦 |
| 33 | Exercise improves depressive symptoms by increasing the number of excitatory synapses in the hippocampus of CUS-Induced depression model rats | 期刊论文 | Xin Liang;Jing Tang;Feng-lei Chao;Yang Zhang;Lin-mu Chen;Fei-fei Wang;Chuan-xue Tan;Yan-min Luo;Qian Xiao;Lei Zhang;Ying-qiang Qi;Lin Jiang;Chun-xia Huang;Yuan Gao;Yong Tang |
| 34 | Fluoxetine improves behavioral performance through protecting the oligodendrocytes in the hippocampus of APP/PS1 transgenic AD mice | 会议论文 | Yi Zhang;Lin Jiang;Chun-ni Zhou;Lei Zhang;Feng-lei Chao;Yong Tang |
| 35 | Effect of running exercise on the number of the neurons in the hippocampus of young transgenic APP/PS1 mice | 期刊论文 | Lin Jiang;Jing Ma;Yi Zhang;Chun-ni Zhou;Lei Zhang;Feng-lei Chao;Lin-mu Chen;Rong Jiang;Hong Wu;Yong Tang |
| 36 | The effects of running exercise on oligodendrocytes in the hippocampus of rats with depression induced by chronic unpredictable stress | 期刊论文 | Jing Tang;Xin Liang;Yang Zhang;Lin-mu Chen;Fei-fei Wang;Chuan-xue Tan;Yan-min Luo;Qian Xiao;Feng-lei Chao;Lei Zhang;Yuan Gao;Chun-xia Huang;Ying-qiang Q;Yong Tang |
| 37 | 跑步锻炼延缓APP/PS1双转基因小鼠内侧前额叶皮质树突棘数量的丢失 | 期刊论文 | 范金花;周春妮;蒋林;晁凤蕾;张毅;罗艳敏;吴永鑫;杨浩;张蕾;唐勇;吴宏 |
| 38 | Running exercise protects oligodendrocytes in the medial prefrontal cortex in chronic unpredictable stress rat model | 期刊论文 | Yanmin Luo;Qian Xiao;Jin Wang;Lin Jiang;Menglan Hu;Yanhong Jiang;Jing Tang;Xin Liang;Yingqiang Qi;Xiaoyun Dou;Yi Zhang;Chunxia Huang;Linmu Chen;Yong Tang |
| 39 | Astrocytes induce proliferation of oligodendrocyte progenitor cells via connexin 47-mediated activation of the ERK/Id4 pathway | 期刊论文 | Liu Zhao-yu;Xu Dan;Wang Shang;Chen Yi;Li Zhen;Gao Xiao-yan;Jiang Lu;Tang Yong;Peng Yan |
| 40 | S1P 通过 S1PR-3/PI3K 促进少突胶质前体细胞增殖机制的研究 | 期刊论文 | 高晓燕;姜露;徐丹;张文锦;唐勇;彭彦 |
| 41 | 早期APP/PS1转基因阿尔茨海默病小鼠海马结构内有髓神经纤维改变的体视学研究 | 期刊论文 | 赵振华;晁凤蕾;张蕾;张毅;周春妮;蒋林;肖倩;罗艳敏;黄维;李常琼;唐炜;李桃;唐勇 |
| 42 | Running exercise protects against myelin breakdown in the absence of neurogenesis in the hippocampus of AD mice | 期刊论文 | Chao Feng-lei;Zhang Lei;Zhang Yi;Zhou Chun-ni;Jiang Lin;Xiao Qian;Luo Yan-min;Lv Fu-lin;He Qi;Tang Yong |
| 43 | Fluoxetine delays the cognitive function decline and synaptic changes in a transgenic mouse model of early Alzheimer's disease | 期刊论文 | Chun-ni Zhou;Feng-lei Chao;Yi Zhang;Lin Jiang;Lei Zhang;Jin-hua Fan;Yong-xin Wu;Xiao-yun Dou;Yong Tang |
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