PTEN介导NR2B磷酸化/CREB通路调控的突触可塑性参与大鼠偏头痛慢性化的维持机制

81671093
2016
H0903.感觉障碍、疼痛与镇痛
陈力学
面上项目
研究员
重庆医科大学
52万元
N-甲基-D-天门冬氨酸受体2B亚型磷酸化;第10号染色体同源丢失性磷酸酶张力蛋白基因;慢性偏头痛;突触可塑性;cAMP反应元件结合蛋白
2017-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Metabotropic glutamate receptor 5 regulates synaptic plasticity in a chronic migraine rat model through the PKC/NR2B signal 期刊论文 Yingying Niu;Xiaoxu Zeng;Lilin Zhao;Yang Zhou;Guangcheng Qin;Dunke Zhang;Qingqing Fu;Jiying Zhou;Lixue Chen
2 Expression of ASIC3 in the Trigeminal Nucleus Caudalis Plays a Role in a Rat Model of Recurrent Migraine 期刊论文 Wang Sha;Wu Bai Xue;Liu Chao Yang;Qin Guang Cheng;Yan Wen Hui;Zhou Ji Ying;Chen Li Xue
3 NR2B-Tyr phosphorylation regulates synaptic plasticity in central sensitization in a chronic migraine rat model 期刊论文 Wang Xue Ying;Zhou Hui Ru;Wang Sha;Liu Chao Yang;Qin Guang Cheng;Fu Qing Qing;Zhou Ji Ying;Chen Li Xue
4 蛋白激酶C参与大鼠慢性偏头痛中枢敏化 期刊论文 吴白雪;王莎;秦光成;肖垚;谢景梅;谭戈;周冀英;陈力学
5 EphrinB/EphB Signaling Contributes to the Synaptic Plasticity of Chronic Migraine Through NR2B Phosphorylation 期刊论文 Jiang Wang;Zhaoyang Fei;Jie Liang;Xue Zhou;Guangcheng Qin;Dunke Zhang;Jiying Zhou;Lixue Chen
6 Up‐regulation of astrocyte excitatory amino acid transporter 2 alleviates central sensitization in a rat model of chronic migraine 期刊论文 Xue Zhou;Jie Liang;Jiang Wang;Zhaoyang Fei;Guangcheng Qin;Dunke Zhang;Jiying Zhou;Lixue Chen
7 Deficiency in the function of inhibitory interneurons contributes to glutamate-associated central sensitization through GABABR2-SynCAM1 signaling in chronic migraine rats 期刊论文 Xiaoxu Zeng;Yingying Niu;Guangcheng Qin;Dunke Zhang;Jiying Zhou;Lixue Chen
8 ASIC3在慢性偏头痛大鼠三叉神经脊束尾核的表达 期刊论文 王莎;吴白雪;刘超阳;秦光成;周冀英;陈力学
9 Inhibition of Nerve Growth Factor Signaling Alleviates Repeated Dural Stimulation-induced Hyperalgesia in Rats 期刊论文 Zhou Huiru;Wang Xueying;Wang Sha;Liu Chaoyang;Fu Qingqing;Qin Guangcheng;Zhou Jiying;Chen Lixue
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