一种新型肺炎链球菌矿化纳米蛋白疫苗——疫苗的构建、热稳定性及其免疫保护效应研究

81571622
2015
H1111.疫苗和免疫预防
张雪梅
面上项目
教授
重庆医科大学
54万元
纳米颗粒;蛋白疫苗;生物矿化;热稳定性;肺炎链球菌
2016-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 ComE, an Essential Response Regulator, Negatively Regulates the Expression of the Capsular Polysaccharide Locus and Attenuates the Bacterial Virulence in Streptococcus pneumoniae 期刊论文 Zheng Yuqiang;Zhang Xuemei;Wang Xiaofang;Wang Libin;Zhang Jinghui;Yin Yibing
2 Expression of Toll-Like Receptor 2 by Dendritic Cells Is Essential for the DnaJ-Delta A146Ply-Mediated Th1 Immune Response against Streptococcus pneumoniae 期刊论文 Wang Xiaofang;Yuan Taixian;Yuan Jun;Su Yufeng;Sun Xiaoyu;Wu Jingwen;Zhang Hong;Min Xun;Zhang Xuemei;Yin Yibing
3 DnaJ (hsp40) of Streptococcus pneumoniae is involved in bacterial virulence and elicits a strong natural immune reaction via PI3K/JNK 期刊论文 Cui Jin;Ma Chenyu;Ye Guo;Shi Yong;Xu Wenchun;Zhong Liang;Wang Jian;Yin Yibing;Zhang Xuemei;Wang Hong
4 肺炎链球菌ΔA146Ply蛋白抵抗鼻咽部感染的研究 期刊论文 吴静雯;王箭;王继超;王晓芳;张雪梅
5 Subcutaneous Immunization with Fusion Protein DnaJ-Delta A146Ply without Additional Adjuvants Induces both Humoral and Cellular Immunity against Pneumococcal Infection Partially Depending on TLR4 期刊论文 Su Yufeng;Li Dagen;Xing Yan;Wang Hong;Wang Jian;Yuan Jun;Wang Xiaofang;Cui Fang;Yin Yibing;Zhang Xuemei
6 肺炎链球菌候选蛋白疫苗DnaJ-△A146Ply通过PI3K/Akt和NF-κB信号通路刺激巨噬细胞诱导免疫应答 期刊论文 粟玉凤;李达根;邢燕;姚华;吴静雯;张雪梅
7 一种基于磷酸钙矿化制备热稳定性疫苗的方法 专利 张雪梅;王婧瑶;闵娅君;胥文春
8 Engineering detoxified pneumococcal pneumolysin derivative DA146PLY for self-biomineralization of calcium phosphate: Assessment of their protective efficacy in murine infection models 期刊论文 Wu jingwen;Wu kaifeng;Xu wenchun;Yuan taixuan;Wang xiaofang;Zhang jinghui;Min yajun;Yin yibing;Zhang xuemei
9 Progranulin Decreases Susceptibility to Streptococcus pneumoniae in Influenza and Protects against Lethal Coinfection 期刊论文 Wang Xiaofang;Yuan Jun;Wang Hong;Gan Ning;Zhang Qun;Liu Bichen;Wang Jingyao;Shu Zhaoche;Rao Lubei;Gou Xuemei;Zhang Hong;Yin Yibing;Zhang Xuemei
10 一种热稳定性蛋白质(多肽)及其制备方法 专利 尹一兵;张雪梅;吴静雯;吴凯峰;肖云菊
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