低氧诱导的氧化型ATM调节乳腺癌CAFs能量代谢重塑的机理及其促乳腺癌侵袭转移研究

81472476
2014
H1807.肿瘤代谢
柳满然
面上项目
教授
重庆医科大学
94万元
能量代谢重塑;氧化型ATM;侵袭转移;C21_乳腺肿瘤;乳癌相关成纤维细胞
2015-01-01到2018-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Cytoplasmic GPER translocation in cancer-associated fibroblasts mediates cAMP/PKA/CREB/glycolytic axis to confer tumor cells with multidrug resistance. 期刊论文 Tenghua Yu;Guanglun Yang;Yixuan Hou;Xi Tang;Chengyi Wu;Xiao-an Wu;Linying Guo;Qing Zhu;Haojun Luo;Yan-e Du;Siyang Wen;Liyun Xu;Jiali Yin;Gang Tu;Manran Liu
2 Cancer associated fibroblast (CAF)-derived IL32 promotes breast cancer cell invasion and metastasis via integrin b3/p38/MAPK signaling. 期刊论文 Siyang Wen;Yixuan Hou;Lixin Fu;Lei Xi;Dan Yang;Maojia Zhao;Yilu Qin;Kexin Sun;Yong Teng;Manran Liu
3 ATM-mediated phosphorylation of cortactin involved in actin polymerization promotes breast cancer cells migration and invasion. 期刊论文 Lei Lang;Yixuan Hou;Yanlin Chen;Gang Tu;Jing Tao;Dan Yang;Lei Xi;Lixin Fu;Kexin Sun;Jiali Yin;Rui Chen;Meixi Peng;Shuiqing Liu;Manran Liu
4 Primed atypical ductal hyperplasia associated fibroblasts promote cell growth and polarity changes of transformed epithelium-like breast cancer MCF-7 cells via miR-200b/c-IKKbsignaling. 期刊论文 Yan Sun;Dan Yang;Lei Xi;Yanlin Chen;Lixin Fu;Kexin Sun;Jiali Yin;Xiaotian Li;Shuiqing Liu;Yilu Qin;Manran Liu;Yixuan Hou
5 Oxidized ATM promotes the abnormal proliferation of breast CAF through keeping intracellular redox homeostasis and activating the PI3K-AKT, ERK-MAPK, and Wnt signaling pathways. 期刊论文 Shifu Tang;Yixuan Hou;Hailong Zhang;Gang Tu;Li Yang;Yifan Sun;Lei Lang;Xi Tang;Yan-e Du;Mingli Zhou;Tenghua Yu;Liyun Xu;Siyang Wen;Chunming Liu;Manran Liu
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