【81271501】小剂量氯胺酮联合异丙酚调整电休克疗效的AMPA受体活性调控机制国家自然基金项目

小剂量氯胺酮联合异丙酚调整电休克疗效的AMPA受体活性调控机制

项目批准号： 81271501

批准年份： 2012

学科分类： H1007.心境障碍

项目负责人：闵苏

资助类别：面上项目

负责人职称：教授

依托单位：重庆医科大学

资助金额： 70万元

关键词：电休克;氯胺酮;抑郁症;麻醉药;AMPA受体

起止时间： 2013-01-01到2016-12-31

中英文摘要
结题摘要
结题报告
项目成果
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序号	标题	类型	作者
1	Effect of Low Dose of Ketamine on Learning Memory Function in Patients Undergoing Electroconvulsive Therapy-A Randomized, Double-Blind, Controlled Clinical Study.	期刊论文	Meng, Huaqing\|Luo, Qinghua\|Chen, Jianmei\|Li, Xiao\|
2	Ketamine-mediated alleviation of electroconvulsive shock-induced memory impairment is associated with the regulation of neuroinflammation and soluble amyloid-beta peptide in depressive-like rats	期刊论文	Min S\|Luo J\|Xie F\|Jin J\|
3	α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体与γ-氨基丁酸受体磷酸化水平在小剂量氯胺酮联合异丙酚调整电休克治疗抑郁症疗效中的作用研究	期刊论文	陈婧\|闵苏\|
4	小剂量氯胺酮复合异丙酚麻醉对抑郁大鼠电休克后海马谷氨酸受体1和γ-氨基丁酸A受体表达的影响	期刊论文	敖丽\|黎平\|刘力\|郝学超\|
5	氯胺酮复合异丙酚麻醉对抑郁大鼠电休克后海马谷氨酸受体亚基1和亚基2的影响	期刊论文	张帆\|任力\|郝学超\|朱贤林\|
6	电休克和氯胺酮对抑郁模型大鼠海马区谷氨酸受体NR_1及GluR_1的影响	期刊论文	黎平\|律峰\|魏珂\|谢飞\|
7	异丙酚对抑郁大鼠电休克治疗后海马神经元自噬的影响	期刊论文	律峰\|罗洁\|魏珂\|谢飞\|
8	Propofol alleviates electroconvulsive shock-induced memory impairment by modulating proBDNF/mBDNF ratio in depressive rats.	期刊论文	Luo Jie\|Min Su\|Ren Li\|Qin Peipei\|
9	Behavioral and molecular responses to electroconvulsive shock differ between genetic and environmental rat models of depression	期刊论文	Wang B\|Li P\|Dong J\|Liu Y\|
10	Propofol prevents electroconvulsive-shock-induced memory impairment through regulation of hippocampal synaptic plasticity in a rat model of depression.	期刊论文	Wang, Bin\|Li, Ping\|Dong, Jun\|Liu, Yuanyuan\|
11	Propofol ameliorates electroconvulsive shock-induced learning and memory impairment by regulation of synaptic metaplasticity via autophosphorylation of CaMKIIa at Thr 305 in stressed rats.	期刊论文	Min, Su\|Hao, Xuechao\|Qin, Peipei\|Zhu, Xianlin\|
12	小剂量氯胺酮联合异丙酚麻醉下电休克对抑郁大鼠海马p-GluR1和p-CaMKⅡα表达的影响	期刊论文	罗洁\|张帆\|朱贤林\|郝学超\|
13	小剂量氯胺酮对抑郁大鼠无抽搐电休克抗抑郁治疗起效时间和治疗疗程的影响	期刊论文	彭丽桦\|律峰\|黎平\|郝学超\|
14	Effects of Low-Dose Ketamine Combined With Propofol on Phosphorylation of AMPA Receptor GluR1 Subunit and GABAA Receptor in Hippocampus of Stressed Rats Receiving Electroconvulsive Shock	期刊论文	Li P\|Ao L\|Hao XC\|Min S\|
15	异丙酚对抑郁大鼠电休克治疗后海马谷氨酸浓度及转运功能的影响	会议论文	朱贤林\|闵苏\|郝学超\|张帆\|
16	Propofol inhibits inflammatory cytokine-mediated glutamate uptake dysfunction to alleviate learning/memory impairment in depressed rats undergoing electroconvulsive shock.	期刊论文	Luo J\|Min S\|Xie F\|Zhang F\|
17	NMDA receptor antagonist enhances antidepressant efficacy and alleviates learning-memory function impairment induced by electroconvulsive shock with regulating glutamate receptors expression in hippocampus.	期刊论文	Zhu Xianlin\|Li Ping\|Lv Feng\|Min Su\|
18	氯胺酮联合氟西汀对抑郁大鼠前额叶nNOS及其配体CAPON表达的影响	期刊论文	黎平\|罗洁\|谢飞\|闵苏\|
19	不同电量电休克对小剂量氯胺酮联合丙泊酚麻醉下抑郁大鼠电休克后学习记忆影响的机制研究	会议论文	任力\|闵苏\|张帆\|罗洁\|
20	Propofol prevents electroconvulsive-shock-induced memory impairment through regulation of hippocampal synaptic plasticity in a rat model of depression.	期刊论文	Wang, Bin\|Li, Ping\|Dong, Jun\|Liu, Yuanyuan\|

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