基于TLR4/MyD88/NF-κB通路研究表面活性蛋白D在骨关节炎软骨细胞凋亡及炎症中的作用机制

81802203
2018
H0608.骨、关节、软组织退行性病变
周炎
青年科学基金项目
副主任医师
武汉大学
21万元
软骨细胞;骨关节炎;炎症;软骨;凋亡
2019-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Chemically modified curcumin (CMC2.24) alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-kappa B/HIF-2 alpha axis 期刊论文 Zhou Yan;Ming Jianghua;Deng Ming;Li Yaming;Li Bochun;Li Jia;Ma Yonggang;Chen Zhonghui;Wang Guirong;Liu Shiqing
2 一种治疗小儿股骨干骨折的桥式牵引外固定支架 专利 周炎;刘世清;明江华;李亚明;马永刚;邓明;陈庆
3 miR-24-3p induces human intervertebral disc degeneration by targeting insulin-like growth factor binding protein 5 and the ERK signaling pathway 期刊论文 Chen Zhonghui;Liu Ming;Zhang Weibing;Deng Ming;Zhou Yan;Li Yaming
4 Ligustilide attenuates nitric oxide-induced apoptosis in rat chondrocytes and cartilage degradation via inhibiting JNK and p38 MAPK pathways 期刊论文 Zhou Yan;Ming Jianghua;Li Yaming;Deng Ming;Chen Qing;Ma Yonggang;Chen Zhonghui;Zhang Yubiao;Liu Shiqing
5 Down-regulation of insulin-like growth factor binding protein 5 is involved in intervertebral disc degeneration via the ERK signalling pathway 期刊论文 Chen Zhonghui;Zhang Weibing;Zhang Nu;Zhou Yan;Hu Geliang;Xue Mingdi;Liu Junhua;Li Yaming
6 Berberine-mediated up-regulation of surfactant protein D facilitates cartilage repair by modulating immune responses via the inhibition of TLR4/NF-kappa B signaling 期刊论文 Zhou Yan;Ming Jianghua;Deng Ming;Li Yaming;Li Bochun;Li Jia;Ma Yonggang;Chen Zhonghui;Liu Shiqing
7 临床骨科学研究 专著 辛安华;王旭东;吕志刚;周炎
8 Exosomes derived from miR-126-3p-overexpressing synovial fibroblasts suppress chondrocyte inflammation and cartilage degradation in a rat model of osteoarthritis 期刊论文 Zhou Yan;Ming Jianghua;Li Yaming;Li Bochun;Deng Ming;Ma Yonggang;Chen Zhonghui;Zhang Yubiao;Li Jia;Liu Shiqing
9 天然免疫介导凋亡-炎症途径参与骨关节炎发病的研究进展 期刊论文 周炎;刘世清
10 Paper CircGLCE alleviates intervertebral disc degeneration by regulating apoptosis and matrix degradation through the targeting of miR-587/STAP1 期刊论文 Chen Zhonghui;Zhang Weibing;Deng Ming;Li Yaming;Zhou Yan
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