靶向雌激素受体非核效应信号通路特异性小分子化合物的设计、合成及其对心血管的选择性保护作用研究

81773557
2017
H3401.合成药物化学
周海兵
面上项目
教授
武汉大学
63万元
先导化合物;核外雌激素受体;雌激素;非基因组效应;心血管保护
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Novel hybrid conjugates with dual estrogen receptor alpha degradation and histone deacetylase inhibitory activities for breast cancer therapy 期刊论文 Zhao Chenxi;Tang Chu;Li Changhao;Ning Wentao;Hu Zhiye;Xin Lilan;Zhou Hai-Bing;Huang Jian
2 Estrogen receptor sensing in living cells by a high affinity turn-on fluorescent probe 期刊论文 Yang Lu;Meng Qiuyu;Hu Zhiye;Ning Wentao;Zheng Jie;Dong Chune;Zhou Hai-Bing
3 Design and synthesis of heteroaromatic-based benzenesulfonamide derivatives as potent inhibitors of H5N1 influenza A virus 期刊论文 Yu Yongshi;Tazeem;Xu Zhichao;Du Liaoqi;Jin Mengyu;Dong Chune;Zhou Hai Bing;Wu Shuwen
4 乳腺癌基因诊断指导精准治疗关键技术创新与应用 奖励 张京伟;魏蕾;周海兵;吴旻;何春江;国世上;敖英;田毅浩;高阳;张尊
5 Design, Synthesis and Biological Evaluation of Pyrano[2,3-b]-naphthoquinone Derivatives as Acetylcholinesterase Inhibitors 期刊论文 Chuanqian Du;Baohua Xie;Ming He;Zhiye Hu;Yu Liu;Xue He;Fanyu Liu;Chen Cheng;Hai-Bing Zhou;Shengtang Huang;Chun'e Dong
6 一种苯并呋喃-2-酮类化合物及其制备方法和应用 专利 周海兵;彭雪珂;胡志烨;宁文涛;董春娥
7 一种含有不同烷基链长的氧桥双环庚烯磺酰胺类化合物及其制备方法与应用 专利 周海兵;吴叔文;蓝柯;胡志烨;宁文涛;李媛媛;董春娥
8 Exploring the PROTAC degron candidates: OBHSA with different side chains as novel selective estrogen receptor degraders (SERDs) 期刊论文 Li Yuanyuan;Zhang Silong;Zhang Jing;Hu Zhiye;Xiao Yuan;Huang Jian;Dong Chune;Huang Shengtang;Zhou Hai Bing
9 Design, synthesis and biological evaluation of novel dual-acting modulators targeting both estrogen receptor alpha (ER alpha) and lysine-specific demethylase 1 (LSD1) for treatment of breast cancer 期刊论文 He Ming;Ning Wentao;Hu Zhiye;Huang Jian;Dong Chune;Zhou Hai-Bing
10 一种芳香甲酰胺类化合物及其在制备抗甲型流感病毒药物中的应用 专利 吴叔文;周海兵;蓝柯;董春娥;余用势
11 Novel class of 7-Oxabicyclo[2.2.1]heptene sulfonamides with long alkyl chains displaying improved estrogen receptor alpha degradation activity 期刊论文 Hu Zhiye;Li Yuanyuan;Xie Baohua;Ning Wentao;Xiao Yuan;Huang Yuan;Zhao Chenxi;Huang Jian;Dong Chune;Zhou Hai-Bing
12 ERβ-Targeted Near-Infrared Inherently Fluorescent Probe: A Potent Tool for ERβ Research 期刊论文 Qiuyu Meng;Baohua Xie;Huiguang Yu;Kang Shen;Xiangping Deng;周海兵;Chune Dong
13 Synthesis and structure-activity relationship study of arylsulfonamides as novel potent H5N1 inhibitors 期刊论文 Yu Yongshi;Tang Qi;Xu Zhichao;Li Siliang;Jin Mengyu;Zhao Zixuan;Dong Chune;Wu Shuwen;Zhou Hai-Bing
14 一种芳杂环和烷基侧链双取代的苯磺酰胺类化合物及其在制备抗甲型流感病毒药物中的应用 专利 吴叔文;周海兵;余用势
15 含有不同功能性侧链结构的氧桥双环-[2.2.1]-庚烯类化合物及其制备与应用 专利 周海兵;吴叔文;蓝柯;李媛媛;张思龙;董春娥
16 一种喹啉甲酰胺类化合物及其制备方法与抗肠道病毒71型的应用 专利 吴叔文;周海兵;蓝柯;许智超
17 一种氨基噻唑类化合物及其制备方法与抗肠道病毒71型的应用 专利 吴叔文;周海兵;蓝柯;许智超
18 二芳基酰肼类化合物在制备抗流感病毒药物中的应用 专利 吴叔文;周海兵;余用势
19 以氧桥双环庚烯类化合物为雌激素受体配体的蛋白水解靶向嵌合体化合物及制备方法与应用 专利 周海兵;胡志烨;宁文涛;黄健;董春娥
20 Construction of benzofuranone library via a metal-free, one-pot intermolecular condensation, and their application as efficient estrogen receptor beta modulators 期刊论文 Peng Xueke;Hu Zhiye;Zhang Jing;Ning Wentao;Zhang Silong;Dong Chune;Shi Xiaodong;Zhou Hai-Bing
21 一种含有硼酸衍生基团的氧桥双环-[2.2.1]-庚烯类化合物、其合成方法及应用 专利 周海兵;杜鹏宇;胡志烨;宁文涛;董春娥
22 针对乳腺癌治疗的PROTACs研究进展 期刊论文 谢宝花;胡志烨;宁文涛;杨录;周海兵
23 Identification of dibucaine derivatives as novel potent enterovirus 2C helicase inhibitors: In vitro, in vivo, and combination therapy study 期刊论文 Tang Qi;Xu Zhichao;Jin Mengyu;Shu Ting;Chen Yinuo;Feng Leilei;Zhang Qiuhan;Lan Ke;Wu Shuwen;Zhou Hai-Bing
24 A high-affinity subtype-selective fluorescent probe for estrogen receptor beta imaging in living cells 期刊论文 Hu Zhiye;Yang Lu;Ning Wentao;Tang Chu;Meng Qiuyu;Zheng Jie;Dong Chune;Zhou Hai-Bing
25 Construction of Benzofuranone Library via Metal-Free, One-Pot Intermolecular Condensation and Their Application as Efficient Estrogen Receptor β Modulators 期刊论文 Xueke Peng;Zhiye Hu;Jing Zhang;Wentao Ning;Chune Dong;Xiaodong Shi;Hai-Bing Zhou
26 Novel Hybrid Conjugates with Dual Suppression of Estrogenic and Inflammatory Activities Display Significantly Improved Potency against Breast Cancer 期刊论文 Nin Wentao;Hu Zhiye;Tang Chu;Yang Lu;Zhang Silong;Dong Chune;Huang Jian;Zhou Hai-Bing
27 Establishment of evaluation criteria for the development of high quality ER alpha-targeted fluorescent probes 期刊论文 Meng Qiuyu;Ma Xiaoyu;Xie Baohua;Deng Xiaofei;Huang Jian;Zhou Hai-Bing;Dong Chune
28 Enantioselective synthesis of novel pyrano[3,2-c]chromene derivatives as AChE inhibitors via an organocatalytic domino reaction 期刊论文 Zheng Jie;He Ming;Xie Baohua;Yang Lu;Hu Zhiye;Zhou Hai-Bing;Dong Chune
29 喹啉-苯并吡喃类新型乙酰胆碱酯酶抑制剂的微波一锅法的设计合成以及生物活性研究(英文) 期刊论文 贺明;谢宝花;贺培;周海兵;黄胜堂;董春娥
30 Rational design of ER alpha targeting hypoxia turn-on fluorescent probes with antiproliferative activity for breast cancer 期刊论文 Meng Qiuyu;Xie Baohua;Ma Xiaoyu;Hu Zhiye;Zhou Fuling;Zhou Hai-Bing;Dong Chune
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